Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Zaher Hanna"'
Autor:
Chunyan Hu, Elena Priceputu, Marc Cool, Pavel Chrobak, Nathalie Bouchard, Clara Forestier, Clifford A. Lowell, Serge Bénichou, Zaher Hanna, Virginie Royal, Paul Jolicoeur
Publikováno v:
The American Journal of Pathology.
Autor:
Nathalie Bouchard, Paul Jolicoeur, Zaher Hanna, Marc Cool, Clifford A. Lowell, Julio Roberto Caceres-Cortes, Elena Priceputu
Publikováno v:
Journal of Virology
Journal of virology, vol 95, iss 17
Journal of virology, vol 95, iss 17
Human immunodeficiency virus (HIV) or simian immunodeficiency virus (SIV) infection causes myelodysplasia, anemia, and accumulation of inflammatory monocytes (CD14+ CD16+) through largely unknown cellular and molecular pathways. The mouse cells thoug
Publikováno v:
Virology. 438:84-97
We studied the impact of HIV Nef on CD8(+) T cells in a mouse model of AIDS, the CD4C/HIV(Nef) transgenic (Tg) mice. We found that negative and positive thymic selections of CD8(+) T cells proceeded normally in Nef Tg mice bred respectively with HY o
Autor:
Paul Jolicoeur, Nathalie Bouchard, Zaher Hanna, Vibhuti P. Dave, Pavel Chrobak, Joël Guertin, Marie-Chantal Simard, Thomas Ndolo
Publikováno v:
The Journal of Immunology. 185:3948-3959
The HIV-1 Nef protein is a major determinant of HIV-1 pathogenicity. It has been found to induce thymocyte depletion, but the mechanisms involved are not completely understood. Also, nothing is known about its effects on thymocyte selection. We used
Autor:
Mathieu Goupil, Paul Jolicoeur, Véronique Dugas, Zaher Hanna, Elena Priceputu, Miriam Marquis, Chunyan Hu, Louis de Repentigny, Pavel Chrobak
Publikováno v:
Journal of Virology. 83:9743-9758
We previously reported that CD4C/human immunodeficiency virus (HIV)Neftransgenic (Tg) mice, expressing Nef in CD4+T cells and cells of the macrophage/dendritic cell (DC) lineage, develop a severe AIDS-like disease, characterized by depletion of CD4+T
Autor:
Paul Jolicoeur, Frank Kirchhoff, Marie-Chantal Simard, Elena Priceputu, Chunyan Hu, Michael Schindler, Steffen Wildum, Zaher Hanna, Patrick Vincent
Publikováno v:
Journal of Virology. 81:4677-4693
We previously reported that the human immunodeficiency virus type 1 NL4-3 Nef is necessary and sufficient to induce a severe AIDS-like disease in transgenic (Tg) mice when the protein is expressed under the regulatory sequences of the human CD4 gene.
Autor:
Ji Ma, Jianyong Zhong, Li-Jun Ma, Taiji Matsusaka, Zaher Hanna, Yiqin Zuo, Iekuni Ichikawa, Agnes B. Fogo, Paul Jolicoeur
Publikováno v:
Journal of the American Society of Nephrology. 17:2832-2843
This study aimed to identify the causative gene for HIV-1 associated nephropathy, a paradigmatic podocytopathy. A previous study demonstrated that transgenic expression of nonstructural HIV-1 genes selectively in podocytes in mice with FVB/N genetic
Autor:
Véronique Dugas, Francine Aumont, Miriam Marquis, Paul Jolicoeur, Zaher Hanna, Daniel Lewandowski, Serge Sénéchal, Louis de Repentigny
Publikováno v:
Infection and Immunity. 74:2382-2391
Candida albicanscauses oropharyngeal candidiasis (OPC) but rarely disseminates to deep organs in human immunodeficiency virus (HIV) infection. Here, we used a model of OPC in CD4C/HIVMuttransgenic (Tg) mice to investigate the role of polymorphonuclea
Publikováno v:
Journal of Biological Chemistry. 281:6940-6954
A well conserved feature of human immunodeficiency virus, type 1 (HIV-1) and simian immunodeficiency virus (SIV) Nef is the interaction with and activation of the human p21-activated kinase 2 (PAK2). The conservation of this interaction in other spec
Publikováno v:
Virology. 346(1):40-52
HIV-1 Nef has the ability to downmodulate CD4 cell surface expression. Several studies have shown that CD4 downregulation is required for efficient virus replication and high infectivity. However, the pathophysiological relevance of this phenomenon i