Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Zaher A. Radi"'
Autor:
Zaher A. Radi, Robert Ostroski
Publikováno v:
Mediators of Inflammation, Vol 2007 (2007)
Hypertensive mice that express the human renin and angiotensinogen genes are used as a model for human hypertension because they develop hypertension secondary to increased renin-angiotensin system activity. Our study investigated the cellul
Externí odkaz:
https://doaj.org/article/1a612f6896dd4099835f2e7524b42757
Publikováno v:
Intestinal Research, Vol 21, Iss 3, Pp 295-305 (2023)
Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a lifelong disease that manifests with chronic intestinal inflammation, sequential fibrosis, and an increased risk of colitis-associated colon cancer (CAC). The
Externí odkaz:
https://doaj.org/article/6eb8bf4bc7784d7792a7758a7a436b61
Autor:
Zaher A. Radi, Yurong Lai
Publikováno v:
Current Opinion in Toxicology. 29:65-69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e5ab5e9fd03b4dbcd15bf8fa071f1d5
https://doi.org/10.1016/j.cotox.2022.02.005
https://doi.org/10.1016/j.cotox.2022.02.005
Autor:
Zaher A. Radi, Nasir Khan
Publikováno v:
Toxicology and Applied Pharmacology. 466:116471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0229cb14d9502503ab9fcb41749e389
https://doi.org/10.1016/j.taap.2023.116471
https://doi.org/10.1016/j.taap.2023.116471
Autor:
Zaher A. Radi, Thomas A. Wynn
Publikováno v:
Toxicologic Pathology. 48:712-717
Immune tolerance is defined by an active state of immune system unresponsiveness to foreign and self-antigens. Loss of immune tolerance to self-antigens and the resulting overexpression of autoantibodies can lead to tissue injury and development of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4f20e77fe2fc0ad0f44f94b02b4d5c
https://doi.org/10.1177/0192623320948805
https://doi.org/10.1177/0192623320948805
Autor:
Zaher A. Radi
Publikováno v:
Toxicologic Pathology. 48:721-724
Influx and efflux kidney tubular transporters are major determinants of the disposition of xenobiotics, including pharmaceutical drugs. On the basolateral membrane of proximal tubular cells, there are influx transporters, such as organic cation trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745a3b710c91c74a2dd8cff08db8931d
https://doi.org/10.1177/0192623320937012
https://doi.org/10.1177/0192623320937012
Publikováno v:
Drug Metabolism and Disposition. 47:802-808
Limited understanding of species differences in kidney transporters is a critical knowledge gap for prediction of drug-induced acute kidney injury, drug interaction, and pharmacokinetics in humans. Here, we report protein abundance data of 19 transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12ae0872482340bbcd6299a9269a718
https://doi.org/10.1124/dmd.119.086579
https://doi.org/10.1124/dmd.119.086579
Autor:
Zaher A. Radi, Gary Seitis, Yutian Zhan, Maria Engel, Stephanie L. Coffing, Katherine Hales, Maik Schuler, Lindsay Tomlinson, Saurabh G. Vispute, Jon C. Cook, Brett D. Hollingshead, Jennifer R. Cheung, Michael Homiski, Elizabeth Rubitski, Andrew Robertson
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 180(1)
Risk management of in vitro aneugens for topically applied compounds is not clearly defined because there is no validated methodology to accurately measure compound concentration in proliferating stratum basale keratinocytes of the skin. Here, we exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6bedfa8cff11eb12e410362f2b71c2e
https://pubmed.ncbi.nlm.nih.gov/33481035
https://pubmed.ncbi.nlm.nih.gov/33481035
Autor:
Jim Finley, Lindsay Tomlinson, Sarah P. Nicholson, Stacey R. Oppenheimer, Jessica L. Moore, Maik Schuler, Nathan Heath Patterson, Kevin Beaumont, Brett D. Hollingshead, Zaher A. Radi, Colleen M. Doshna, Casey Ritenour, Richard M. Caprioli, Shawn P. O'Neil, Jon C. Cook, Jason Barricklow, Amanda King-Ahmad, Saurabh G. Vispute, Jeremy L. Norris
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 123
Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human risk assessment. For topical drugs, there is no standard method for measuring drug concentrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2406de3fb3f2281d80af4febb5bd971f
https://pubmed.ncbi.nlm.nih.gov/33872740
https://pubmed.ncbi.nlm.nih.gov/33872740
Autor:
W. Mark Vogel, Douglas J. Ball, Mark Collinge, Zaher A. Radi, Andrea L. Nilson, Christopher J. Bowman
Publikováno v:
Regulatory Toxicology and Pharmacology. 94:306-322
Tofacitinib, an oral Janus kinase (JAK) inhibitor for treatment of rheumatoid arthritis, targets JAK1, JAK3, and to a lesser extent JAK2 and TYK2. JAK1/3 inhibition impairs gamma common chain cytokine receptor signaling, important in lymphocyte devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94327b99bd6719d388cb0d76a1099a28
https://doi.org/10.1016/j.yrtph.2018.02.006
https://doi.org/10.1016/j.yrtph.2018.02.006