Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Zahava Siegfried"'
Autor:
Adi Amar-Schwartz, Vered Ben Hur, Amina Jbara, Yuval Cohen, Georgina D Barnabas, Eliran Arbib, Zahava Siegfried, Bayan Mashahreh, Fouad Hassouna, Asaf Shilo, Mohammad Abu-Odeh, Michael Berger, Reuven Wiener, Rami Aqeilan, Tamar Geiger, Rotem Karni
Publikováno v:
eLife, Vol 11 (2022)
The mTORC1 substrate, S6 Kinase 1 (S6K1), is involved in the regulation of cell growth, ribosome biogenesis, glucose homeostasis, and adipogenesis. Accumulating evidence has suggested a role for mTORC1 signaling in the DNA damage response. This is mo
Externí odkaz:
https://doaj.org/article/415f0119bfe2430898b264371e2f1a67
Autor:
Vered Ben-Hur, Polina Denichenko, Zahava Siegfried, Avi Maimon, Adrian Krainer, Ben Davidson, Rotem Karni
Publikováno v:
Cell Reports, Vol 3, Iss 1, Pp 103-115 (2013)
Ribosomal S6 kinase 1 (S6K1) is a major mTOR downstream signaling molecule that regulates cell size and translation efficiency. Here, we report that short isoforms of S6K1 are overproduced in breast cancer cell lines and tumors. Overexpression of S6K
Externí odkaz:
https://doaj.org/article/ef605f8684744ead9409e441b207ff99
Publikováno v:
International Journal of Cell Biology, Vol 2013 (2013)
Alternative splicing is a fundamental step in regulation of gene expression of many tumor suppressors and oncogenes in cancer. Signalling through the Ras-MAPK and PI3K-mTOR pathways is misregulated and hyperactivated in most types of cancer. However,
Externí odkaz:
https://doaj.org/article/3226d6abbf274d3cb166aaef5f3b15a2
Autor:
Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L. Johnson, Tomer M. Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan-Gotthold, Lewis C. Cantley, Erez Y. Levanon, Steven Gallinger, Adrian R. Krainer, Talia Golan, Rotem Karni
Publikováno v:
Nature. 617:147-153
Pancreatic ductal adenocarcinoma (PDA) is characterized by aggressive local invasion and metastatic spread, leading to high lethality. Although driver gene mutations during PDA progression are conserved, no specific mutation is correlated with the di
Publikováno v:
RNA. 29:506-515
Alternative splicing (AS) of mRNAs is an essential regulatory mechanism in eukaryotic gene expression. AS misregulation, caused by either dysregulation or mutation of splicing factors, has been shown to be involved in cancer development and progressi
Autor:
Adi Amar-Schwartz, Yuval Cohen, Antony Elhaj, Vered Ben-Hur, Zahava Siegfried, Rotem Karni, Talya Dor
Publikováno v:
Human Molecular Genetics.
Duchene muscular dystrophy (DMD) and Becker muscular dystrophy (BMD) are genetic neuromuscular disorders that affect skeletal and cardiac muscle resulting from mutations in the dystrophin gene (DMD), coding for dystrophin protein. Read-through therap
Supplementary Figure 1 from Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442e3983f748eaeeb19748b18dc2f06c
https://doi.org/10.1158/0008-5472.22376765.v1
https://doi.org/10.1158/0008-5472.22376765.v1
Supplementary Figure 4 from Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f07f0fc88f06b0b30cf8e5f34b8fb2
https://doi.org/10.1158/0008-5472.22376756.v1
https://doi.org/10.1158/0008-5472.22376756.v1
Supplementary Figure 3 from Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308502f614807f7e87f90680034fecb4
https://doi.org/10.1158/0008-5472.22376759
https://doi.org/10.1158/0008-5472.22376759
Supplementary Figure 2 from Chromatin Immunoprecipitation–on-Chip Reveals Stress-Dependent p53 Occupancy in Primary Normal Cells but Not in Established Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb2c08addb71eec5034ab71d67ed829
https://doi.org/10.1158/0008-5472.22376762.v1
https://doi.org/10.1158/0008-5472.22376762.v1