Determination of SOX9 Gene Expression In Brain Tumours Among East Coast Malaysia Population

Autor: Farizan Ahmad, Wan Taib Wr, Zahary Mn, Abu Bakar Nh, Abd Latif Az, Hasnan Jaafar, Dzali Nb

Publikováno v: IIUM Medical Journal Malaysia. 18

Introduction: SOX9, a members of SOX family, plays a significant roles in developmental processes during embryogenesis, including brain tissue. Few studies have shown that SOX9 has been involved in tumourigenesis of several types of cancer including

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::402fa6a2e200207b1e7b1865a3bd38cd
https://doi.org/10.31436/imjm.v18i2.99

Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium.

Autor: Møller P; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway. moller.pal@gmail.com., Seppälä T; Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland.; Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Center, Tampere University Hospital, Tampere, Finland., Dowty JG; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Haupt S; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany.; Data Mining and Uncertainty Quantification (DMQ), Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany., Dominguez-Valentin M; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway., Sunde L; Department of Clinical Genetics, Aalborg University Hospital, 9000, Aalborg, Denmark.; Department of Biomedicine, Aarhus University, DK-8000, Aarhus, Denmark., Bernstein I; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark.; Institute of Clinical Medicine, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark., Engel C; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107, Leipzig, Germany., Aretz S; Institute of Human Genetics, National Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, 53127, Bonn, Germany., Nielsen M; Department of Clinical Genetics, Leids Universitair Medisch Centrum, 2300RC, Leiden, The Netherlands., Capella G; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Evans DG; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Burn J; Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK., Holinski-Feder E; Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336, Munich, Germany.; MGZ - Center of Medical Genetics, 80335, Munich, Germany., Bertario L; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology, IRCCS, 20141, Milan, Italy., Bonanni B; Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology, IRCCS, 20141, Milan, Italy., Lindblom A; Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 76, Stockholm, Sweden., Levi Z; Department Rabin Medical Center, Service High Risk GI Cancer Gastroenterology, Petach Tikva, Israel., Macrae F; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Winship I; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Plazzer JP; The Royal Melbourne Hospital, Melbourne, Australia., Sijmons R; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Laghi L; Department of Medicine and Surgery, Laboratory of Molecular Gastroenterology, IRCCS Humanitas Research Hospital, University of Parma, Parma, Italy., Valle AD; Hospital Fuerzas Armadas, Grupo Colaborativo Uruguayo, Investigación de Afecciones Oncológicas Hereditarias (GCU), Montevideo, Uruguay., Heinimann K; Medical Genetics, Institute for Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland., Half E; Gastrointestinal Cancer Prevention Unit, Gastroenterology Department, Rambam Health Care Campus, Haifa, Israel., Lopez-Koestner F; Programa Cáncer Heredo Familiar Clínica Universidad de los Ande, Santiago, Chile., Alvarez-Valenzuela K; Programa Cáncer Heredo Familiar Clínica Universidad de los Ande, Santiago, Chile., Scott RJ; University of Newcastle and the Hunter Medical Research Institute, Callaghan, Australia., Katz L; Department of Gastroenterology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Laish I; The Department of Gastroenterology, High Risk and GI Cancer Prevention Clinic, Gastro-Oncology Unit, Sheba Medical Center, Ramat Gan, Israel., Vainer E; Department of Gastroenterology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel., Vaccaro CA; Hereditary Cancer Program (PROCANHE), Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina., Carraro DM; Genomic and Molecular Biology Group, A.C.Camargo Cancer Center, Sao Paulo, Brazil., Gluck N; Department of Gastroenterology, Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel., Abu-Freha N; The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel., Stakelum A; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Kennelly R; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Winter D; St Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Rossi BM; Hospital Sirio Libanes, Sao Paulo, Brazil., Greenblatt M; University of Vermont, Larner College of Medicine, Burlington, VT, 05405, USA., Bohorquez M; University of Tolima, Tolima, Colombia., Sheth H; Foundation for Research in Genetics and Endocrinology, FRIGE House, Jodhpur Village Road, Satellite Ahmedabad, Ahmedabad, 380015, India., Tibiletti MG; Ospedale di Circolo ASST Settelaghi, Centro di Ricerca Tumori Eredo-Familiari, Università dell'Insubria, Varese, Italy., Lino-Silva LS; Instituto Nacional de Cancerologia, Mexico, DF, Mexico., Horisberger K; Department of Abdominal and Transplantation Surgery, Universitätsspital Zürich, Rämistrasse 100, CH-8091, Zürich, Switzerland., Portenkirchner C; Department of Abdominal and Transplantation Surgery, Universitätsspital Zürich, Rämistrasse 100, CH-8091, Zürich, Switzerland., Nascimento I; 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Department of Gastrointestinal Surgery, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland.; Applied Tumour Genomics Research Program, University of Helsinki, Helsinki, Finland., Peltomäki P; Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland., Therkildsen C; The Danish HNPCC Register, Gastro Unit, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Lindberg LJ; The Danish HNPCC Register, Gastro Unit, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark., Thorlacius-Ussing O; Department of Surgical Gastroenterology, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark.; Institute of Clinical Medicine, Aalborg University Hospital, Aalborg University, 9100, Aalborg, Denmark., von Knebel Doeberitz M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.; Clinical Cooperation Unit Applied Tumour Biology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Loeffler M; Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany., Rahner N; Institute of Human Genetics, University Clinic Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany., Steinke-Lange V; Campus Innenstadt, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, 80336, Munich, Germany.; MGZ - Center of Medical Genetics, 80335, Munich, Germany., Schmiegel W; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Vangala D; Department of Medicine, Knappschaftskrankenhaus, Ruhr-University Bochum, Bochum, Germany., Perne C; Institute of Human Genetics, National Center for Hereditary Tumor Syndromes, Medical Faculty, University of Bonn, 53127, Bonn, Germany., Hüneburg R; Department of Internal Medicine, University Hospital Bonn, Bonn, Germany., de Vargas AF; Genetics Unit, Hospital Vargas de Caracas, Caracas, Venezuela.; Escuela de Medicina Jose Maria Vargas, Universidad, Central de Venezuela, UCV, Caracas, Venezuela., Latchford A; 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Department of Clinical Genetics, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands., Hall MJ; Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA., Hampel H; Division of Human Genetics, The Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA., Williams H; Department of Urology, Geisinger Medical Center, Danville, PA, 17822, USA., Okkels H; Department of Molecular Diagnostics, Aalborg University, Aalborg, Denmark., Lubiński J; Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University in Szczecin, Szczecin, Poland., Reece J; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Ngeow J; Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Cancer Genetics Service National Cancer Centre Singapore, Singapore, Singapore., Guillem JG; Gastrointestinal Surgery, University of North Carolina, Chapel Hill, NC, USA., Arnold J; New Zealand Familial Gastrointestinal Cancer Service, Auckland, New Zealand., Wadt K; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark., Monahan K; St Mark's Hospital & Imperial College, London, UK., Senter L; Ohio State University Comprehensive Cancer Center, Columbus, OH, 43210, USA., Rasmussen LJ; Department of Cellular and Molecular Medicine, Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark., van Hest LP; Department of Clinical Genetics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Ricciardiello L; IRCCS AOU di Bologna, and Department of Medical and Surgical Sciences - University of Bologna, Bologna, Italy., Kohonen-Corish MRJ; Woolcock Institute of Medical Research, Glebe, Sydney, NSW, 2037, Australia., Ligtenberg MJL; Department of Human Genetics and Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands., Southey M; Monash Health Translation Precinct, Monash University, Clayton South, VIC, 3169, Australia., Aronson M; Zane Cohen Centre, Sinai Health System, Toronto, Ontario, Canada., Zahary MN; Faculty of Health Sciences, University Sultan Zainal Abidin, Kuala Terengganu, Terengganu, Malaysia., Samadder NJ; Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, 85054, USA., Poplawski N; Adelaide Medical School, University of Adelaide, Adelaide, SA, 5000, Australia.; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, 5000, Australia., Hoogerbrugge N; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Morrison PJ; Regional Medical Genetics Centre, Belfast HSC Trust, City Hospital Campus, Queen's University Belfast, Belfast, Northern Ireland, UK., James P; Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, VIC, 3010, Australia., Lee G; Genomics Platform Group, Centre for Cancer Research, University of Melbourne, Parkville, VIC, Australia., Chen-Shtoyerman R; The Biology Department, Ariel University, Ariel and the Oncogenetic Clinic, The Clinical Genetics Institute, Kaplan Medical Center, Rehovot, Israel., Ankathil R; Human Genome Centre, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia., Pai R; Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, 85259, USA., Ward R; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia., Parry S; New Zealand Familial Gastrointestinal Cancer Service, Auckland, New Zealand., Dębniak T; Department of Genetics and Pathology, Pomeranian Medical University in Szczecin, Szczecin, Poland., John T; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., van Overeem Hansen T; Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, DK-2100, Copenhagen, Denmark., Caldés T; Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Yamaguchi T; Department of Clinical Genetics, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan., Barca-Tierno V; Department of Genetics, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain., Garre P; Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC, Madrid, Spain., Cavestro GM; Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milan, Italy., Weitz J; Technische Universität Dresden, Dresden, Germany., Redler S; Institute of Human Genetics, University Clinic Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany., Büttner R; Department of Pathology, University Hospital of Cologne, Cologne, Germany., Heuveline V; Engineering Mathematics and Computing Lab (EMCL), Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany., Hopper JL; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Win AK; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia., Lindor N; Department of Health Science Research, Mayo Clinic Arizona, Phoenix, USA., Gallinger S; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada., Le Marchand L; University of Hawaii Cancer Center, Honolulu, USA., Newcomb PA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Figueiredo J; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA., Buchanan DD; Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.; University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre, Parkville, Victoria, Australia.; Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia., Thibodeau SN; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA., Ten Broeke SW; Leids Universitair Medisch Centrum, Leiden, Netherlands., Hovig E; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway.; Department of Informatics, Centre for Bioinformatics, University of Oslo, Oslo, Norway., Nakken S; Department of Tumor Biology, Institute of Cancer Research, The Norwegian Radium Hospital, 0379, Oslo, Norway.; Centre for Cancer Cell Reprogramming (CanCell), Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Pineda M; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Dueñas N; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Brunet J; Hereditary Cancer Program, Institut Català d'Oncologia-IDIBELL, L; Hospitalet de Llobregat, 08908, Barcelona, Spain., Green K; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Lalloo F; Division of Evolution and Genomic Sciences, Manchester Centre for Genomic Medicine, University of Manchester, Manchester University NHS Foundation Trust, Manchester, M13 9WL, UK., Newton K; Department of Surgery, Central Manchester University Hospitals NHS Foundation Trust and University of Manchester, Manchester, UK., Crosbie EJ; Gynaecological Oncology Research Group, Manchester University NHS Foundation Trust, Manchester, UK.; Division of Cancer Sciences, University of Manchester, Manchester, UK., Mints M; Division of Obstetrics and Gyneacology, Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden., Tjandra D; Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia.; Department of Medicine, Melbourne University, Melbourne, Australia., Neffa F; 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Bethesda Khs Duisburg, University Witten-Herdecke, Herdecke, Germany., Ahadova A; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Kloor M; Department of Applied Tumour Biology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany., Sampson JR; Division of Cancer and Genetics, Institute of Medical Genetics, Cardiff University School of Medicine, Heath Park, Cardiff, CF14 4XN, UK., Jenkins MA; Centre of Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

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Serum adiponectin and resistin: Correlation with metabolic syndrome and its associated criteria among temiar subtribe in Malaysia.

Autor: Zahary MN; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300, Kuala Terengganu, Terengganu, Malaysia., Harun NS; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300, Kuala Terengganu, Terengganu, Malaysia., Yahaya R; Faculty of Medicine, Universiti Sultan Zainal Abidin, Medical Campus, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia., Nik Him NAS; Faculty of Medicine, Universiti Sultan Zainal Abidin, Medical Campus, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia., Rohin MAK; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300, Kuala Terengganu, Terengganu, Malaysia., Ridzwan NH; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300, Kuala Terengganu, Terengganu, Malaysia., Jumli MN; Faculty of Health Sciences, Universiti Sultan Zainal Abidin, Gong Badak Campus, 21300, Kuala Terengganu, Terengganu, Malaysia., Wan Jusoh AF; Faculty of Medicine, Universiti Sultan Zainal Abidin, Medical Campus, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, Malaysia. Electronic address: azizulfadzli@unisza.edu.my.

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Polymorphisms of cell cycle regulator genes CCND1 G870A and TP53 C215G: Association with colorectal cancer susceptibility risk in a Malaysian population.

Autor: Zahary MN; Human Genome Centre, School of Medical Sciences, University of Science Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia ; School of Diagnostic and Biomedicine, Faculty of Health Sciences, Sultan Zainal Abidin University, Kuala Terengganu, Terengganu 21300, Malaysia., Ahmad Aizat AA; Human Genome Centre, School of Medical Sciences, University of Science Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia., Kaur G; Institute for Research in Molecular Medicine, University of Science Malaysia, Minden, Penang 11800, Malaysia., Yeong Yeh L; Department of Medicine, School of Medical Sciences, University of Science Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia., Mazuwin M; Department of Surgery, School of Medical Sciences, University of Science Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia., Ankathil R; Human Genome Centre, School of Medical Sciences, University of Science Malaysia Health Campus, Kubang Kerian, Kelantan 16150, Malaysia.

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Germline mutation analysis of MLH1 and MSH2 in Malaysian Lynch syndrome patients.

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