Supersaturation and Solubilization upon In Vitro Digestion of Fenofibrate Type I Lipid Formulations: Effect of Droplet Size, Surfactant Concentration and Lipid Type

Autor: Vladimir Katev, Sonya Tsibranska-Gyoreva, Zahari Vinarov, Slavka Tcholakova

Publikováno v: Pharmaceutics, Vol 13, Iss 8, p 1287 (2021)

Lipid-based formulations (LBF) enhance oral drug absorption by promoting drug solubilization and supersaturation. The aim of the study was to determine the effect of the lipid carrier type, drop size and surfactant concentration on the rate of fenofi

Externí odkaz: https://doaj.org/article/719a88edea17408bb0cb426afa87e3c7

Cholesterol solubilization: Interplay between phytosterols, saponins and lipid digestion products

Autor: Sonya Tsibranska-Gyoreva, Vladimir Petkov, Vladimir Katev, Delyan Krastev, Zahari Vinarov, Slavka Tcholakova

Publikováno v: Colloids and Surfaces A: Physicochemical and Engineering Aspects. 662:131052

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb823d1e373ed0d10a714dc183c7bd26
https://doi.org/10.1016/j.colsurfa.2023.131052

Interplay between bulk aggregates, surface properties and foam stability of nonionic surfactants

Autor: Fatmegyul Mustan, Nadya Politova-Brinkova, Zahari Vinarov, Damiano Rossetti, Pip Rayment, Slavka Tcholakova

Publikováno v: Advances in colloid and interface science. 302

In our previous study (Mustan et al. 2021) we showed that foams formed from two oil-soluble nonionic surfactants (Span 60 and Brij 72) can remain stable for more than 10 days at room temperature at high sugar concentration. The major aim of the curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c90bc69ea9d227b325f8dd33526be5
https://pubmed.ncbi.nlm.nih.gov/35245855

Current challenges and future perspectives in oral absorption research : an opinion of the UNGAP network

Autor: Saskia N. de Wildt, Patrick Augustijns, Anette Müllertz, Mark McAllister, Cordula Stillhart, Brendan T. Griffin, James Butler, Kateřina Valentová, Andreas Bernkop-Schnürch, Nigel Davies, Caitriona M. O'Driscoll, Christos Reppas, Hannah Batchelor, Clive G. Wilson, Filippos Kesisoglou, Mirko Koziolek, Maria Vertzoni, Alan R. Mackie, Bertil Abrahamsson, Christopher J.H. Porter, Kiyohiko Sugano, Jadwiga Paszkowska, Zahari Vinarov, Didier Dupont, Martin Kuentz, Nikoletta Fotaki, Janneke Keemink, Jens Ceulemans, Petr Pavek, Gøril Eide Flaten, Elena Toader, Per Artursson, Vincent Jannin, Philippe Berben, Neil Parrott, Antonio J. Meléndez-Martínez

Publikováno v: Advanced Drug Delivery Reviews, 171, 289-331
Advanced Drug Delivery Reviews
Advanced Drug Delivery Reviews, Elsevier, 2021, 171, pp.289-331. ⟨10.1016/j.addr.2021.02.001⟩
Vinarov, Z, Abrahamsson, B, Artursson, P, Batchelor, H, Berben, P, Bernkop-Schnurch, A, Butler, J, Ceulemans, J, Davies, N, Dupont, D, Flaten, G E, Fotaki, N, Griffin, B T, Jannin, V, Keemink, J, Kesisoglou, F, Koziolek, M, Kuentz, M, Mackie, A, Melendez-Martinez, A J, McAllister, M, Mullertz, A, O'Driscoll, C M, Parrott, N, Paszkowska, J, Pavek, P, Porter, C J H, Reppas, C, Stillhart, C, Sugano, K, Toader, E, Valentova, K, Vertzoni, M, De Wildt, S N, Wilson, C G & Augustijns, P 2021, ' Current challenges and future perspectives in oral absorption research : An opinion of the UNGAP network ', Advanced Drug Delivery Reviews, vol. 171, pp. 289-331 . https://doi.org/10.1016/j.addr.2021.02.001
Advanced Drug Delivery Reviews, 171, pp. 289-331

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33eec6da8069c781165c09e0bfc8b4fe
https://strathprints.strath.ac.uk/75801/1/Vinarov_etal_ADDR_2021_Current_challenges_and_future_perspectives_in_oral_absorption_research.pdf

Effect of surfactant molecular structure on Progesterone solubilization

Autor: Zahari Vinarov, Petra Dobreva, Slavka Tcholakova

Publikováno v: Journal of Drug Delivery Science and Technology. 43:44-49

Progesterone is a hydrophobic drug (LogP = 3.9) with solubility-limited oral bioavailability. One approach to improve its aqueous solubility is by solubilization in micellar surfactant solutions. We investigate systematically the effect of surfactant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a1b38ea356b757c62b0d76cc0d17f1a
https://doi.org/10.1016/j.jddst.2017.09.014