Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels.

Autor: Schüssler M; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Schott K; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Fuchs NV; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Oo A; Department of Pediatrics, Emory University, Atlanta, USA., Zahadi M; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Rauch P; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany., Kim B; Department of Pediatrics, Emory University, Atlanta, USA.; Center for Drug Discovery, Children's Healthcare of Atlanta, Atlanta, USA., König R; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Langen, Germany.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 25. Date of Electronic Publication: 2023 Aug 25.