A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.

Autor: Tan TK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. tiong.tan@rdm.ox.ac.uk., Rijal P; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Rahikainen R; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Keeble AH; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK., Schimanski L; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK., Hussain S; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Harvey R; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Hayes JWP; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Edwards JC; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., McLean RK; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Martini V; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Pedrera M; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Thakur N; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Conceicao C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Dietrich I; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Shelton H; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Ludi A; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Wilsden G; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Browning C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Zagrajek AK; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Bialy D; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Bhat S; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Stevenson-Leggett P; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Hollinghurst P; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK.; Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK., Tully M; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Moffat K; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Chiu C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Waters R; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Gray A; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Azhar M; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Mioulet V; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Newman J; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Asfor AS; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Burman A; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Crossley S; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Hammond JA; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Tchilian E; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Charleston B; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Bailey D; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Tuthill TJ; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Graham SP; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF, UK., Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK., Malinauskas T; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK., Huo J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Rutherford Appleton Laboratory, Protein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute, Harwell, Didcot, OX11 0FA, UK., Tree JA; National Infection Service, Public Health England, Porton Down, Salisbury, SP4 0JG, UK., Buttigieg KR; National Infection Service, Public Health England, Porton Down, Salisbury, SP4 0JG, UK., Owens RJ; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Rutherford Appleton Laboratory, Protein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute, Harwell, Didcot, OX11 0FA, UK., Carroll MW; National Infection Service, Public Health England, Porton Down, Salisbury, SP4 0JG, UK.; Nuffield Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK., Daniels RS; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., McCauley JW; Worldwide Influenza Centre, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK., Stuart DI; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford, UK.; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK., Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Howarth M; Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. mark.howarth@bioch.ox.ac.uk., Townsend AR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DS, UK. alain.townsend@imm.ox.ac.uk.; Centre for Translational Immunology, Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK. alain.townsend@imm.ox.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2021 Jan 22; Vol. 12 (1), pp. 542. Date of Electronic Publication: 2021 Jan 22.

Following Acute Encephalitis, Semliki Forest Virus is Undetectable in the Brain by Infectivity Assays but Functional Virus RNA Capable of Generating Infectious Virus Persists for Life.

Autor: Fragkoudis R; The Roslin Institute and Royal (Dick) School of Veterinary Studies, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK. rennos.fragkoudis@pirbright.ac.uk.; The School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK. rennos.fragkoudis@pirbright.ac.uk., Dixon-Ballany CM; The Roslin Institute and Royal (Dick) School of Veterinary Studies, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK. cattiwano@yahoo.com., Zagrajek AK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK. Adrian.zagrajek@pirbright.ac.uk., Kedzierski L; Department of Microbiology and Immunology, Faculty of Medicine, Dentistry and Health Sciences at The Peter Doherty Institute for Infection and Immunity and the Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 792 Elizabeth Street, Melbourne 3000, Australia. lukaszk@unimelb.edu.au., Fazakerley JK; The Roslin Institute and Royal (Dick) School of Veterinary Studies, College of Medicine & Veterinary Medicine, University of Edinburgh, Edinburgh, Midlothian EH25 9RG, UK. john.fazakerley@unimelb.edu.au.; Department of Microbiology and Immunology, Faculty of Medicine, Dentistry and Health Sciences at The Peter Doherty Institute for Infection and Immunity and the Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 792 Elizabeth Street, Melbourne 3000, Australia. john.fazakerley@unimelb.edu.au.

Publikováno v: Viruses [Viruses] 2018 May 18; Vol. 10 (5). Date of Electronic Publication: 2018 May 18.