The Vedotin Antibody-Drug Conjugate Payload Drives Platform-Based Nonclinical Safety and Pharmacokinetic Profiles.

Autor: Neff-LaFord HD; Seagen, Inc., Bothell, Washington., Carratt SA; Seagen, Inc., Bothell, Washington., Carosino C; Seagen, Inc., Bothell, Washington., Everds N; Seagen, Inc., Bothell, Washington.; ABBM Consulting, LLC, Seattle, Washington., Cardinal KA; Seagen, Inc., Bothell, Washington., Duniho S; Seagen, Inc., Bothell, Washington., Schutten MM; Seagen, Inc., Bothell, Washington., Frantz C; Seagen, Inc., Bothell, Washington., Zuch de Zafra C; Seagen, Inc., Bothell, Washington., Harstad EB; Seagen, Inc., Bothell, Washington.

Publikováno v: Molecular cancer therapeutics [Mol Cancer Ther] 2024 Oct 01; Vol. 23 (10), pp. 1483-1493.

[Neutrophil-to-lymphocyte ratio as a predictor of intestinal resection in incarcerated inguinal hernias].

Autor: Perez RD; School of Medicine, Antenor Orrego Private University, Trujillo, Peru., Villena MA; School of Medicine, Antenor Orrego Private University, Trujillo, Peru.; Belen Hospital of Trujillo, Trujillo, Peru., Zavaleta-Corvera C; School of Medicine, Antenor Orrego Private University, Trujillo, Peru., Caballero-Alvarado J; School of Medicine, Antenor Orrego Private University, Trujillo, Peru.; Regional Hospital of Trujillo, Trujillo, Peru., Zafra C; School of Medicine, Antenor Orrego Private University, Trujillo, Peru., Pozzuoli G; School of Medicine, Antenor Orrego Private University, Trujillo, Peru.

Publikováno v: Khirurgiia [Khirurgiia (Mosk)] 2024 (6), pp. 51-57.

An Insertion Within SIRPβ1 Shows a Dual Effect Over Alzheimer's Disease Cognitive Decline Altering the Microglial Response.

Autor: García-Alberca JM; Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., de Rojas I; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sanchez-Mejias E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Biologia Celular, Genetica y Fisiologia, Facultad de Ciencias, Instituto de Investigacion Biomedica de Malaga-IBIMA, Universidad de Málaga, Málaga, Spain., Garrido-Martín D; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Section of Statistics, Faculty of Biology, Universitat de Barcelona (UB), Barcelona, Spain., Gonzalez-Palma L; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Jimenez S; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio CSIC, Universidad de Sevilla, Seville, Spain., Pino-Angeles A; Unidad de Lípidos y Arteriosclerosis, Servicio de Medicina Interna, Hospital Universitario Reina Sofia, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba, Córdoba, Spain.; Centro de Investigación Biomédicaen Red de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain., Cruz-Gamero JM; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.; Institute of Psychiatry and Neuroscience of Paris, Université de Paris, INSERM U1266, Paris, France., Mendoza S; Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., Alarcón-Martín E; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Muñoz-Castro C; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio CSIC, Universidad de Sevilla, Seville, Spain., Real LM; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Tena JJ; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, Sevilla, Spain., Polvillo R; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, Sevilla, Spain., Govantes F; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, Sevilla, Spain., Lopez A; Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide/Consejo Superior de Investigaciones Científicas/Junta de Andalucía, Sevilla, Spain., Royo-Aguado JL; Instituto SantÁngela, Sevilla, Spain., Navarro V; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio CSIC, Universidad de Sevilla, Seville, Spain., Gonzalez I; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Ruiz M; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Reyes-Engel A; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Gris E; Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., Bravo MJ; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Lopez-Gutierrez L; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.; Laboratory of Histology, Neuroanatomy and Neuropathology, ULB Neuroscience, Institute (UNI), Faculty of Medicine, Université Libre de Bruxelles, Brussels, Belgium., Mejias-Ortega M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Biologia Celular, Genetica y Fisiologia, Facultad de Ciencias, Instituto de Investigacion Biomedica de Malaga-IBIMA, Universidad de Málaga, Málaga, Spain., De la Guía P; Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., López de la Rica M; Alzheimer Research Center and Memory Clinic, Instituto Andaluz de Neurociencia (IANEC), Málaga, Spain., Ocejo O; Centro Residencial Almudena, Malaga, Spain., Torrecilla J; Centro Residencial Almudena, Malaga, Spain., Zafra C; Centro Residencial Almudena, Malaga, Spain., Nieto MD; Hospital Hermanas Hospitalarias del Sagrado Corazón, Málaga, Spain., Urbano C; Hospital Hermanas Hospitalarias del Sagrado Corazón, Málaga, Spain., Jiménez-Sánchez R; Hospital Hermanas Hospitalarias del Sagrado Corazón, Málaga, Spain., Pareja N; Asociación de Familiares de Enfermos de Alzheimer de la Axarquía, Vélez-Málaga, Spain., Luque M; Centro Residencial Élite, Málaga, Spain., García-Peralta M; Centro Residencial Élite, Málaga, Spain., Carrillejo R; Asociación Criptana de Enfermos de Alzheimer, Campo de Criptana, Spain., Furniet MDC; Asociación de Familiares de Alzheimer de Archidona, Archidona, Spain., Rueda L; Asociación de Familiares de Alzheimer de Archidona, Archidona, Spain., Sánchez-Fernández A; Residencia DomusViFuentesol, Alhaurín de la Torre, Spain., Mancilla T; Residencia DomusViFuentesol, Alhaurín de la Torre, Spain., Peña I; Residencia DomusViFuentesol, Alhaurín de la Torre, Spain., García-Casares N; Departamento de Medicina, Facultad de Medicina, Universidad de Málaga, Málaga, Spain., Moreno-Grau S; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Hernández I; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Montrreal L; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Quintela I; Fundación Pública Galega de Medicina Xenómica, Centro Nacional de Genotipado, IDIS, Santiago de Compostela, Spain., González-Pérez A; Centro Andaluz de Estudios Bioinformáticos (CAEBI), Sevilla, Spain., Calero M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.; Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Franco-Macías E; Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain., Macías J; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Menéndez-González M; Servicio de Neurología, Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.; Departamento de Medicina, Universidad de Oviedo, Oviedo, Spain., Frank-García A; Department of Neurology, Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, La Paz University Hospital, Madrid, Spain., Huerto Vilas R; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Diez-Fairen M; Department of Neurology, Unit of Neurodegenerative Diseases, Hospital Universitari Germans Triasi Pujol and Germans Triasi Pujol Research Institute (IGTP) Badalona, Barcelona, Spain.; Department of Neurology, Memory Disorders Unit, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain., Lage C; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., García-Madrona S; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., García-González P; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valero S; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sotolongo-Grau O; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Pérez-Cordón A; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Rábano A; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Arias Pastor A; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., Pastor AB; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Espinosa A; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Corma-Gómez A; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Martín Montes Á; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Department of Neurology, Instituto de Investigación Sanitaria del Hospital Universitario La Paz, IdiPAZ, La Paz University Hospital, Madrid, Spain.; Department of Neurology, La Paz University Hospital, Madrid, Spain., Sanabria Á; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Martínez Rodríguez C; Hospital de Cabueñes, Gijón, Spain., Buiza-Rueda D; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain., Rodriguez-Rodriguez E; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain., Ortega G; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alvarez I; Department of Neurology, Unit of Neurodegenerative Diseases, Hospital Universitari Germans Triasi Pujol and Germans Triasi Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Rosas Allende I; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain., Pineda JA; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Rosende-Roca M; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Bernal Sánchez-Arjona M; Unidad de Demencias, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain., Fernández-Fuertes M; Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain., Alegret M; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Roberto N; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain., Del Ser T; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Garcia-Ribas G; Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain., Sánchez-Juan P; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Pastor P; Department of Neurology, Unit of Neurodegenerative Diseases, Hospital Universitari Germans Triasi Pujol and Germans Triasi Pujol Research Institute (IGTP) Badalona, Barcelona, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain., Bullido MJ; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Centro de Biología Molecular Severo Ochoa (UAM-CSIC), Madrid, Spain., Álvarez V; Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain., Mir P; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC, Universidad de Sevilla, Seville, Spain.; Departamento de Medicina, Facultad de Medicina, Universidad de Sevilla, Seville, Spain., Medina M; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain., Marquié M; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sáez ME; Centro Andaluz de Estudios Bioinformáticos (CAEBI), Sevilla, Spain., Carracedo Á; Fundación Pública Galega de Medicina Xenómica, Centro Nacional de Genotipado, IDIS, Santiago de Compostela, Spain.; Grupo de Medicina Xenómica CIBERER-CIMUS, Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Laplana M; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.; Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida, Spain., Tomas-Gallardo L; Proteomics and Biochemistry Unit, Andalusian Centre for Developmental Biology, CSIC-Pablo de Olavide University, Seville, Spain., Orellana A; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Tárraga L; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boada M; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Fibla Palazon J; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain.; Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida, Spain., Vitorica J; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Bioquimica y Biologia Molecular, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain.; Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio CSIC, Universidad de Sevilla, Seville, Spain., Ruiz A; Research Center and Memory Clinic, ACE Alzheimer Center Barcelona, Universitat Internacional de Catalunya, Barcelona, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Guigo R; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain., Gutierrez A; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Departamento Biologia Celular, Genetica y Fisiologia, Facultad de Ciencias, Instituto de Investigacion Biomedica de Malaga-IBIMA, Universidad de Málaga, Málaga, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (2), pp. 601-618.

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations.

Autor: Ackley D; Eli Lilly and Co. Inc., Lilly Corporate Center, Indianapolis, IN, 46285, USA., Birkebak J; Gilead Sciences Inc., 333 Lakeside Dr, Foster City, CA, 94404, USA. Electronic address: joanne.birkebak@gilead.com., Blumel J; Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Bourcier T; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., de Zafra C; Seagen, 21823 30th Drive SE, Bothell, WA, 98021, USA., Goodwin A; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Halpern W; Genentech Inc., 1 DNA Way, South San Francisco, CA, 94080, USA., Herzyk D; Merck & Co., Inc., West Point, PA, USA., Kronenberg S; Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center, Basel, Switzerland., Mauthe R; Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, USA., Shenton J; Amgen Inc., Translational Safety & Bioanalytical Sciences, Thousand Oaks, CA, USA., Shuey D; Incyte Corporation, 1801 Augustine Cut-off, Wilmington, DE, USA., Wange RL; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA.

Publikováno v: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2023 Feb; Vol. 138, pp. 105327. Date of Electronic Publication: 2022 Dec 28.

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