Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zafer Hatahet"'
Autor:
Richard E. Honkanen, Kai Ming Chou, Zafer Hatahet, Jang Yang Chang, Yun Yen, James E. Cleaver, Yih Wen Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 105:16578-16583
Human DNA polymerase eta (pol eta) can replicate across UV-induced pyrimidine dimers, and defects in the gene encoding pol eta result in a syndrome called xeroderma pigmentosum variant (XP-V). XP-V patients are prone to the development of cancer in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fcaf047ad2b580843f7318c8197677
https://doi.org/10.1073/pnas.0808589105
https://doi.org/10.1073/pnas.0808589105
Publikováno v:
Proceedings of the National Academy of Sciences. 112
Obesity and the metabolic syndrome have evolved to be major health issues throughout the world. Whether loss of genome integrity contributes to this epidemic is an open question. DNA polymerase η (pol η), encoded by the xeroderma pigmentosum (XP-V)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87711017589b8a46982e1fa88a19ff2d
https://doi.org/10.1073/pnas.1506954112
https://doi.org/10.1073/pnas.1506954112
Publikováno v:
Journal of Molecular Biology. 290:667-684
When ionizing radiation traverses a DNA molecule, a combination of two or more base damages, sites of base loss or single strand breaks can be produced within 1–4 nm on opposite DNA strands, forming a multiply damaged site (MDS). In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5aca9dfd1ff6eeba0c64e662f0c91913
https://doi.org/10.1006/jmbi.1999.2892
https://doi.org/10.1006/jmbi.1999.2892
Publikováno v:
Europe PubMed Central
Escherichia coli possesses two DNA glycosylase/apurinic lyase activities with overlapping substrate specificities, endonuclease III and endonuclease VIII, that recognize and remove oxidized pyrimidines from DNA. Endonuclease III is encoded by the nth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34687b24fa115b734d10f2b0a2e5d1b8
https://doi.org/10.1128/jb.179.11.3773-3782.1997
https://doi.org/10.1128/jb.179.11.3773-3782.1997
Publikováno v:
Journal of Biological Chemistry. 269:18814-18820
5-Hydroxy-2'-deoxycytidine (5-OHdC) and 5-hydroxy-2'-deoxyuridine (5-OHdU) are major products of oxidative DNA damage with mutagenic potential. Until now, no enzymatic activity responsible for their removal has been identified. We report here that bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::403f42e683c8bb6a07b93c8451cc8c2d
https://doi.org/10.1016/s0021-9258(17)32239-1
https://doi.org/10.1016/s0021-9258(17)32239-1
Publikováno v:
Journal of Biological Chemistry. 269:16260-16268
We have purified a novel endonuclease from Escherichia coli that recognizes deoxyinosine, a deamination product of deoxyadenosine in DNA. This activity, which we named deoxyinosine 3' endonuclease, is different from the known hypoxanthine DNA N-glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5492cc0895d648d2022173abc2bcfebd
https://doi.org/10.1016/s0021-9258(17)34002-4
https://doi.org/10.1016/s0021-9258(17)34002-4
Publikováno v:
Biochemistry. 33:1255-1264
Endonuclease VIII, a novel presumptive DNA repair enzyme, was isolated from Escherichia coli by FPLC1 purification. The enzyme was found in strains that contained or lacked endonuclease III and was purified by radial flow S-Sepharose, Mono S, phenyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d8be0db1d1412b688e618247605ba9
https://doi.org/10.1021/bi00171a028
https://doi.org/10.1021/bi00171a028
Publikováno v:
Journal of Molecular Biology. 236:514-530
Free radicals produce a broad spectrum of damages to DNA, a major proportion of which includes ring fragmentation and contraction products of DNA bases as well as abasic sites. In this study, the mutagenic potential fo two pyrimidine ring fragmentati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8edac24065a0f5bee4433b3c207fa387
https://doi.org/10.1006/jmbi.1994.1162
https://doi.org/10.1006/jmbi.1994.1162
Autor:
Zafer Hatahet, Margaret Maccabee, Justin Courcelle, Susan S. Wallace, Richard Bockrath, Janet Evans, Hirioshi Ide
Publikováno v:
Mutation Research/Genetic Toxicology. 299:147-156
We have used thymine glycol and dihydrothymine as representative ring saturation products resulting from free-radical interaction with DNA pyrimidines, and urea glycosides and beta-ureidoisobutyric acid (UBA) as models for pyrimidine-ring fragmentati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb4c1185750766879e02867f9a69df2
https://doi.org/10.1016/0165-1218(93)90092-r
https://doi.org/10.1016/0165-1218(93)90092-r
Publikováno v:
Journal of Biological Chemistry. 266:1469-1477
The processing of unrepaired DNA lesions is a key to understanding and predicting the biological end points of particular DNA damages. In this study, we prepared single-stranded f1 phage (f1-K12) DNA containing dihydrothymine or beta-ureidoisobutyric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b90367205f93ad7b105759efc7101409
https://doi.org/10.1016/s0021-9258(18)52318-8
https://doi.org/10.1016/s0021-9258(18)52318-8