Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Zafer Gurel"'
Autor:
Zafer Gurel, Michael S. Luy, Qianyun Luo, Nicholas L. Arp, Amy K. Erbe, Aparna H. Kesarwala, Jing Fan, Randall J. Kimple
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionLactate is a pivotal molecule with diverse functions in the metabolic reprogramming of cancer cells. Beyond its role in metabolism, lactate exerts a modulatory effect within the tumor microenvironment; it is utilized by stromal cells and
Externí odkaz:
https://doaj.org/article/e11c06729ad144b8b224cd5c1aa245f1
Autor:
Christine M Sorenson, Zafer Gurel, Yong-Seok Song, Kyle D Peterson, Barbara A Blodi, Nader Sheibani
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297135 (2024)
Age-related macular degeneration (AMD) is a vision threatening disease in older adults. Anti-VEGF treatment is effective for the majority of neovascular AMD (nAMD) patients, although approximately 30% of nAMD patients have an incomplete response for
Externí odkaz:
https://doaj.org/article/aac38f7c859d491182daf612a28022c1
Autor:
Andrea Pennati, Jacques Galipeau, Zachary Morris, Christian Capitini, Mahfuzur Rahman, Zafer Gurel, Randall Kimple
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/0665a5fe90e94b39823187d4db0ec134
Autor:
Andrew M. Baschnagel, Saakshi Kaushik, Arda Durmaz, Steve Goldstein, Irene M. Ong, Lindsey Abel, Paul A. Clark, Zafer Gurel, Ticiana Leal, Darya Buehler, Gopal Iyer, Jacob G. Scott, Randall J. Kimple
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Non-small cell lung cancer (NSCLC) brain metastasis cell lines and in vivo models are not widely accessible. Herein we report on a direct-from patient-derived xenograft (PDX) model system of NSCLC brain metastases with genomic annotation use
Externí odkaz:
https://doaj.org/article/cf6bf8b2cb75421fa4dbf71ed4ff419a
Autor:
Christine M. Sorenson, Yong-Seok Song, Ismail S. Zaitoun, Shoujian Wang, Barbara A. Hanna, Soesiawati R. Darjatmoko, Zafer Gurel, Debra L. Fisk, Colleen M. McDowell, Ryan M. McAdams, Nader Sheibani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Adenosine receptors (AR) are widely expressed in a variety of tissues including the retina and brain. They are involved in adenosine-mediated immune responses underlying the onset and progression of neurodegenerative diseases. The expression of AR ha
Externí odkaz:
https://doaj.org/article/02459f7142584f92902c60fc09be27df
Autor:
Christine M. Sorenson, Shoujian Wang, Soesiawati R. Darjatmoko, Zafer Gurel, Bo Liu, Nader Sheibani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Tight regulation of positive and negative regulators of angiogenesis is essential, particularly in the eye where their dysregulation can lead to vision loss. Thrombospondin-1 (TSP1) is a matricellular protein that negatively regulates angiogenesis an
Externí odkaz:
https://doaj.org/article/8b2d0ff302994558a13a760b3f5109cf
Autor:
Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178198 (2017)
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and neovascul
Externí odkaz:
https://doaj.org/article/6d7417dca5314dd4a62f17a51bc601f9
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e95561 (2014)
Hyperglycemia is the primary cause of the majority of diabetes complications, including diabetic retinopathy (DR). Hyperglycemic conditions have a detrimental effect on many tissues and cell types, especially the retinal vascular cells including earl
Externí odkaz:
https://doaj.org/article/7eb42a8f8db44e15995e2ddc56e02788
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103148 (2014)
Astrocytes are macroglial cells that have a crucial role in development of the retinal vasculature and maintenance of the blood-retina-barrier (BRB). Diabetes affects the physiology and function of retinal vascular cells including astrocytes (AC) lea
Externí odkaz:
https://doaj.org/article/07e83c53e6974442bebbab6cf59471db
Publikováno v:
Mol Carcinog
Autophagy is an evolutionarily conserved cell survival mechanism that degrades damaged proteins and organelles to generate cellular energy during times of stress. Recycling of these cellular components occurs in a series of sequential steps with mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1998c192c3a9d08f7d0e00ea3045c96
https://doi.org/10.1002/mc.23372
https://doi.org/10.1002/mc.23372