Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Zaesung No"'
Autor:
Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T Cole, Priscille Brodin
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000645 (2009)
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tub
Externí odkaz:
https://doaj.org/article/99417d33f11047f2814f85afb272f7e0
Autor:
Sunju Kong, Keumhyun Kim, Soohyun Kim, Sujin Ahn, Marc P. Windisch, Jong Yeon Hwang, Zaesung No, Suyeon Jo, Hyangsuk Jeong, Hee-Young Kim
Publikováno v:
European Journal of Medicinal Chemistry. 78:35-42
In this report we describe 2-iminobenzimidazole (IBI) analogs, identified during the course of a phenotypic high-throughput screening campaign, as novel hepatitis C virus (HCV) inhibitors. A series of IBI derivatives was synthesized and evaluated for
Autor:
Zaesung No, MoonKyeong Ju, Jonathan Cechetto, Lee Yunmi, Junwon Kim, Peter Sommer, Junghwan Kim, Jaewan Yoon, Tae-Hee Kim, Sung-Jun Han
Publikováno v:
Molecules and Cells. 36:212-218
A total of 140,000 compounds were screened in a targetfree cell-based high throughput assay against HIV-1 infection, and a subset of 81 promising compounds was identified. Secondary screening of these 81 compounds revealed two putative human RNaseH2
Autor:
Sung-Jun Han, Eunjung Park, Dongsik Park, Tae-Hee Kim, Jinhwa Lee, Suyeon Jo, Michel Liuzzi, Doohyun Lee, Jiyoun Nam, Jeongjin Kwon, Sujin Ahn, Moon Kyeong Ju, Jong Yeon Hwang, Jonathan Cechetto, Jihyun Choi, Inhee Choi, Junwon Kim, Peter Sommer, Junghwan Kim, Yoonae Ko, Zaesung No, Ahn Jiye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:153-157
We identified a novel class of triazolothienopyrimidine (TTPM) compounds as potent HIV-1 replication inhibitors during a high-throughput screening campaign that evaluated more than 200,000 compounds using a cell-based full replication assay. Herein,
Autor:
Ryang Yeo Kim, Jaeseung Kim, Young-Mi Kim, Sanghee Kim, Sunhee Kang, Kiyean Nam, Min Jung Seo, Zaesung No
Publikováno v:
European journal of medicinal chemistry. 125
The anti-tubercular activity of 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl)imidazo [1,2-a]pyridine-3-carboxamide (Q203) is modified by varying its side chain. In this study, we synthesized Q203 analogues with different
Publikováno v:
European Journal of Pharmacology. 685:141-148
Phosphodiesterase-4 (PDE-4) is responsible for metabolizing adenosine 3',5'-cyclic monophosphate that reduces the activation of a wide range of inflammatory cells including eosinophils. PDE-4 inhibitors are under development for the treatment of resp
Autor:
Young Sik Cho, Chang Min Park, Ikyon Kim, Dong Ju Jeon, Hyung Rae Kim, Zaesung No, Young Lan Hyun, Jong Hwan Song, Nam Sook Kang, Jin Ryul Ha, Joon Won Jeong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:922-926
Described herein is design, synthesis, and biological evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatme
Publikováno v:
Tetrahedron Letters. 50:1229-1235
An efficient route to synthesize biologically interesting 8-aryl-1,2,3,4-tetrahydroisoquinoline has been developed. It involves the Pd-catalyzed direct arylation of 3,4-dihydroisoquinolones via C–H bond activation with aryl iodides to afford a vari
Autor:
Zaesung No, Sueg-Geun Lee
Publikováno v:
Magnetic Resonance in Chemistry. 41:283-286
The complete analyses of the 1H and 13C NMR spectra of the ortho ester analogues of etoposide are reported and differentiation of the α and β isomers of these derivatives is suggested by using the γ-gauche effect upon the 13C chemical shift. Copyr
Autor:
Sujin Ahn, Ryang Yeo Kim, Zaesung No, Saeyeon Lee, Jungjun Kim, Yoonae Ko, Sunhee Kang, Mooyoung Seo, Hwankyu Kang, Inhee Choi, Jiyoun Nam, Kiyean Nam, Seijin Park, Jeong Jea Seo, Jaeseung Kim, Jichan Jang, Hyungjun Kim, Kevin Pethe, Young-Mi Kim, Min Jung Seo
Publikováno v:
Journal of medicinal chemistry. 57(12)
A critical unmet clinical need to combat the global tuberculosis epidemic is the development of potent agents capable of reducing the time of multi-drug-resistant (MDR) and extensively-drug-resistant (XDR) tuberculosis therapy. In this paper, we repo