Functional profiling of murine glioma models highlights targetable immune evasion phenotypes.

Autor: Mikolajewicz N; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Tatari N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada.; Department of Biomedicine, University Hospital Basel, Basel, Switzerland., Wei J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Savage N; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada., Granda Farias A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Dimitrov V; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Chen D; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Zador Z; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Canada., Dasgupta K; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Aguilera-Uribe M; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Xiao YX; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Lee SY; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Mero P; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., McKenna D; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Canada., Venugopal C; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Canada., Brown KR; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada., Han H; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada., Singh S; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada. ssingh@mcmaster.ca.; Centre for Discovery in Cancer Research (CDCR), McMaster University, Hamilton, Canada. ssingh@mcmaster.ca.; Department of Surgery, Faculty of Health Sciences, McMaster University, Hamilton, Canada. ssingh@mcmaster.ca., Moffat J; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Canada. jason.moffat@sickkids.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Canada. jason.moffat@sickkids.ca.; Institute for Biomedical Engineering, University of Toronto, Toronto, Canada. jason.moffat@sickkids.ca.

Publikováno v: Acta neuropathologica [Acta Neuropathol] 2024 Nov 27; Vol. 148 (1), pp. 74. Date of Electronic Publication: 2024 Nov 27.

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Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.

Autor: Gwynne WD; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Suk Y; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Michael G DeGroote School of Medicine, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Custers S; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Mikolajewicz N; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada., Chan JK; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Zador Z; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Chafe SC; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Zhai K; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Escudero L; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Zhang C; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Zaslaver O; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Chokshi C; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Shaikh MV; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Bakhshinyan D; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Burns I; Michael G DeGroote School of Medicine, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Chaudhry I; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Nachmani O; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada., Mobilio D; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Maich WT; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Mero P; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Brown KR; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada., Quaile AT; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Venugopal C; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada., Moffat J; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Institute for Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Montenegro-Burke JR; Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, ON M5S 3E1, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: rafa.montenegro@utoronto.ca., Singh SK; Department of Surgery, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada; Center for Discovery in Cancer Research (CDCR), McMaster University, 1280 Main St W, Hamilton, ON L8S 4L8, Canada. Electronic address: ssingh@mcmaster.ca.

Publikováno v: Cancer cell [Cancer Cell] 2022 Dec 12; Vol. 40 (12), pp. 1488-1502.e7. Date of Electronic Publication: 2022 Nov 10.

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Earlier Surgery Reduces Complications in Acute Traumatic Thoracolumbar Spinal Cord Injury: Analysis of a Multi-Center Cohort of 4108 Patients.

Autor: Balas M; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Guttman MP; Division of General Surgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Badhiwala JH; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Lebovic G; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Health Policy Management and Evaluation, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Nathens AB; Division of General Surgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.; Trauma Quality Programs, American College of Surgeons, Chicago, Illinois, USA., da Costa L; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Sunnybrook Research Institute, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada., Zador Z; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Spears J; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Fehlings MG; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Spine Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Wilson JR; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Health Policy Management and Evaluation, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Spine Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada., Witiw CD; Division of Neurosurgery, Department of Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.; Institute of Health Policy Management and Evaluation, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.; Spine Program, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Journal of neurotrauma [J Neurotrauma] 2022 Feb; Vol. 39 (3-4), pp. 277-284. Date of Electronic Publication: 2021 Apr 26.