Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zackery W. Dentmon"'
Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs
Publikováno v:
Molecules, Vol 25, Iss 21, p 5165 (2020)
The NS5B RNA-dependent RNA polymerase of the hepatitis C virus (HCV) is a validated target for nucleoside antiviral drug therapy. We endeavored to synthesize and test a series of 4′-thionucleosides with a monophosphate prodrug moiety for their anti
Externí odkaz:
https://doaj.org/article/f4e94f10dd7c4592a745e71d2a847424
Autor:
George W. Koszalka, Kamalesh P. Ruppa, Polina Lyuboslavsky, David S. Menaldino, Raymond Dingledine, Dennis C. Liotta, Stephen F. Traynelis, Zackery W. Dentmon, Lawrence J. Wilson, Scott J. Myers, Robert Zaczek, Yesim Altas Tahirovic
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 379:41-52
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B-selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c1e8e93e3ee0c58291395f09218349
https://doi.org/10.1124/jpet.120.000370
https://doi.org/10.1124/jpet.120.000370
Publikováno v:
Synlett.
An analysis of nucleoside active metabolite potencies against Hepatitis C virus (HCV) versus their parent ground-state energetic conformational bias as calculated by density functional theory suggested that nucleotides with a small difference between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c60c2f256d794348dd9d61642843acf
https://doi.org/10.1055/a-1904-0249
https://doi.org/10.1055/a-1904-0249
Autor:
James P. Snyder, Dennis C. Liotta, Zackery W. Dentmon, Pieter B. Burger, Yuhong Du, Thomas M. Kaiser, Haian Fu, Qi Shi
Publikováno v:
Arkivoc. 2021:25-43
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b4c2912671de98a22f394363c53a332
https://doi.org/10.24820/ark.5550190.p011.304
https://doi.org/10.24820/ark.5550190.p011.304
Autor:
Perry W. Bartsch, Julien Sourimant, Thalia Le, Edgars Jecs, Nicole Pribut, Richard K. Plemper, Stephen C. Pelly, Robert Wilson, Zackery W. Dentmon, Savita Sharma, Pieter B. Burger, Jeong-Joong Yoon, Dennis C. Liotta, Thomas M. Kaiser, Soyon S. Hwang
Publikováno v:
ACS Infect Dis
A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound 2 in particular exhibite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4cce3380433cbafe8e4064585046da3
https://doi.org/10.1021/acsinfecdis.9b00524
https://doi.org/10.1021/acsinfecdis.9b00524
Autor:
Zackery W. Dentmon, Christopher E. Dalloul, Dennis C. Liotta, Thomas M. Kaiser, Savita Sharma
Publikováno v:
ACS Med Chem Lett
[Image: see text] Parkinson’s disease (PD) is a debilitating and common neurodegenerative disease. New insights implicating c-Abl activation as a driving force in PD have opened a new drug development avenue for PD treatment beyond the symptomatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b64bc06fce3582107178fb411f7e6f
https://doi.org/10.1021/acsmedchemlett.9b00612
https://doi.org/10.1021/acsmedchemlett.9b00612
Autor:
Scott J, Myers, Kamalesh P, Ruppa, Lawrence J, Wilson, Yesim A, Tahirovic, Polina, Lyuboslavsky, David S, Menaldino, Zackery W, Dentmon, George W, Koszalka, Robert, Zaczek, Raymond J, Dingledine, Stephen F, Traynelis, Dennis C, Liotta
Publikováno v:
J Pharmacol Exp Ther
We describe a clinical candidate molecule from a new series of glutamate N-methyl-d-aspartate receptor subunit 2B–selective inhibitors that shows enhanced inhibition at extracellular acidic pH values relative to physiologic pH. This property should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db965d485c48ecef3089d635d22d3940
https://pubmed.ncbi.nlm.nih.gov/34493631
https://pubmed.ncbi.nlm.nih.gov/34493631
Synthesis and Antiviral Activity of a Series of 2′-C-Methyl-4′-thionucleoside Monophosphate Prodrugs
Publikováno v:
Molecules, Vol 25, Iss 5165, p 5165 (2020)
Molecules
Volume 25
Issue 21
Molecules
Volume 25
Issue 21
The NS5B RNA-dependent RNA polymerase of the hepatitis C virus (HCV) is a validated target for nucleoside antiviral drug therapy. We endeavored to synthesize and test a series of 4&prime
thionucleosides with a monophosphate prodrug moiety for th
thionucleosides with a monophosphate prodrug moiety for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb588d2f99a065ef902feb264adf849c
https://doi.org/10.3390/molecules25215165
https://doi.org/10.3390/molecules25215165
Autor:
Savita Sharma, Christopher E. Dalloul, Dennis C. Liotta, Thomas M. Kaiser, Zackery W. Dentmon
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1491-1491
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7dd5af9bc3c9a247fd5f2d2155376a30
https://doi.org/10.1021/acsmedchemlett.0c00336
https://doi.org/10.1021/acsmedchemlett.0c00336
Autor:
Qi Shi, Zackery W. Dentmon, Claudiu T. Supuran, Thomas M. Kaiser, Daniela Vullo, James P. Snyder, Mariangela Ceruso
Publikováno v:
ACS Medicinal Chemistry Letters. 6:518-522
A method capable of identifying novel synthetic targets for small molecule lead optimization has been developed. The FRESH (FRagment-based Exploitation of modular Synthesis by vHTS) approach relies on a multistep synthetic route to a target series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5efb01e0480cb47baa043f732481f144
https://doi.org/10.1021/acsmedchemlett.5b00062
https://doi.org/10.1021/acsmedchemlett.5b00062