Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zackery T. Knauss"'
Autor:
James N. Bates, Santhosh M. Baby, Paulina M. Getsy, Gregory A. Coffee, Yee-Hsee Hsieh, Zackery T. Knauss, Albert Dahan, Jason A. Bubier, Peter M. MacFarlane, Devin Mueller, Stephen J. Lewis
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract N-acetyl-L-cysteine (L-NAC) is a proposed therapeutic for opioid use disorder. This study determined whether co-injections of L-NAC (500 μmol/kg, IV) or its highly cell-penetrant analogue, L-NAC methyl ester (L-NACme, 500 μmol/kg, IV), pre
Externí odkaz:
https://doaj.org/article/7cf134f1aa4b40f786d4d28221785b6e
Autor:
Jennifer McDonough, Naveen K. Singhal, Paulina M. Getsy, Katherine Knies, Zackery T. Knauss, Devin Mueller, James N. Bates, Derek S. Damron, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine in
Externí odkaz:
https://doaj.org/article/b770ebd95e5f4062957719f54007718e
Autor:
Paulina M. Getsy, Gregory A. Coffee, James N. Bates, Theodore Parran, Lee Hoffer, Santhosh M. Baby, Peter M. MacFarlane, Zackery T. Knauss, Derek S. Damron, Yee-Hsee Hsieh, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The ability of morphine to decrease cysteine transport into neurons by inhibition of excitatory amino acid transporter 3 (EAA3) may be a key molecular mechanism underlying the acquisition of physical and psychological dependence to morphine. This stu
Externí odkaz:
https://doaj.org/article/25505fc3abd147f1bfb54bb923d7270b
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2024)
We examined whether co-injections of the cell-permeant D-cysteine analogues, D-cysteine ethyl ester (D-CYSee) and D-cysteine ethyl amide (D-CYSea), prevent acquisition of physical dependence induced by twice-daily injections of fentanyl, and reverse
Externí odkaz:
https://doaj.org/article/5ab96a619e0f445aae20d91926abf672
Autor:
James N. Bates, Paulina M. Getsy, Gregory A. Coffee, Santhosh M. Baby, Peter M. MacFarlane, Yee-Hsee Hsieh, Zackery T. Knauss, Jason A. Bubier, Devin Mueller, Stephen J. Lewis
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The molecular mechanisms underlying the acquisition of addiction/dependence on morphine may result from the ability of the opioid to diminish the transport of L-cysteine into neurons via inhibition of excitatory amino acid transporter 3 (EAA3). The o
Externí odkaz:
https://doaj.org/article/d549c8fe16774f9597f7ae5c9d895bb5
Autor:
Zackery T. Knauss, Caden J. Hearn, Nathan C. Hendryx, Fanan S. Aboalrob, Yazmin Mueller-Figueroa, Derek S. Damron, Stephen J. Lewis, Devin Mueller
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Despite their inclination to induce tolerance, addictive states, and respiratory depression, synthetic opioids are among the most effective clinically administered drugs to treat severe acute/chronic pain and induce surgical anesthesia.
Externí odkaz:
https://doaj.org/article/5f48ef3432c24fceb43496f33c5a0a65
Autor:
Zackery T. Knauss, Howard C. Cromwell, Najae M. Bolden-Hall, Marko Filipovic, Jasmine P. Smith, Joseph A. Lubera, Jacob E. Bischoff, Kylee A. Smith, Melanie M. Queener, Robert Goldsmith, Melissa K. Miller
Publikováno v:
Behavioural processes. 181
Being motivated means exerting effort toward a goal. The 'law of least work' emphasizes a preference for exerting relatively less effort. The law crosses boundaries among species and between physical and mental work. Organisms should be highly sensit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abcc34c65aaac6103fecad3b79aa0022
https://pubmed.ncbi.nlm.nih.gov/32966870
https://pubmed.ncbi.nlm.nih.gov/32966870