Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Zackary Falls"'
Autor:
Melissa Van Norden, Zackary Falls, Sapan Mandloi, Brahm H. Segal, Bora E. Baysal, Ram Samudrala, Peter L. Elkin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Intra-organism biodiversity is thought to arise from epigenetic modification of constituent genes and post-translational modifications of translated proteins. Here, we show that post-transcriptional modifications, like RNA editing, may also
Externí odkaz:
https://doaj.org/article/b55971b1c57b43fbb50a94f454ea9ef3
Autor:
Tzu-Yin Kuo, Chi-Hua Lu, Zackary Falls, Gail Jette, Walter Gibson, Peter L. Elkin, Kenneth E. Leonard, Edward M. Bednarczyk, David M. Jacobs
Publikováno v:
Drug and Alcohol Dependence Reports, Vol 12, Iss , Pp 100278- (2024)
Background: Patients with alcohol use disorder (AUD) and high-risk opioid use are at risk of serious complications. The purpose of this study was to estimate the prevalence of and factors associated with high-risk opioid use in patients with an alcoh
Externí odkaz:
https://doaj.org/article/a11a315abdef448b8d39bd41b5b7ad72
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The two most common reasons for attrition in therapeutic clinical trials are efficacy and safety. We integrated heterogeneous data to create a human interactome network to comprehensively describe drug behavior in biological systems, with the goal of
Externí odkaz:
https://doaj.org/article/b02b200680cb41068d86deb5fdacbb82
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The worldwide outbreak of SARS-CoV-2 in early 2020 caused numerous deaths and unprecedented measures to control its spread. We employed our Computational Analysis of Novel Drug Opportunities (CANDO) multiscale therapeutic discovery, repurposing, and
Externí odkaz:
https://doaj.org/article/51ed7f8055474300811527e0478070de
Autor:
L. Palanikumar, Laura Karpauskaite, Mohamed Al-Sayegh, Ibrahim Chehade, Maheen Alam, Sarah Hassan, Debabrata Maity, Liaqat Ali, Mona Kalmouni, Yamanappa Hunashal, Jemil Ahmed, Tatiana Houhou, Shake Karapetyan, Zackary Falls, Ram Samudrala, Renu Pasricha, Gennaro Esposito, Ahmed J. Afzal, Andrew D. Hamilton, Sunil Kumar, Mazin Magzoub
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Amyloid aggregation of mutant p53 contributes to its loss of tumor suppressor function and oncogenic gain-of-function. Here, the authors use a protein mimetic to abrogate mutant p53 aggregation and rescue p53 function, which inhibits cancer cell prol
Externí odkaz:
https://doaj.org/article/aabfbc8d47544f739652c54bd2eb3f1f
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
The human immunodeficiency virus 1 (HIV-1) protease is an important target for treating HIV infection. Our goal was to benchmark a novel molecular docking protocol and determine its effectiveness as a therapeutic repurposing tool by predicting inhibi
Externí odkaz:
https://doaj.org/article/9a98cb185bd24bdcbacc0948df1ba0e0
Autor:
Liana Bruggemann, Zackary Falls, William Mangione, Stanley A. Schwartz, Sebastiano Battaglia, Ravikumar Aalinkeel, Supriya D. Mahajan, Ram Samudrala
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 997 (2023)
Pharmacogenomics is a rapidly growing field with the goal of providing personalized care to every patient. Previously, we developed the Computational Analysis of Novel Drug Opportunities (CANDO) platform for multiscale therapeutic discovery to screen
Externí odkaz:
https://doaj.org/article/6ff710e6963a4b23b0482be9c8c3119a
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objective Ascertain the optimal interaction scoring criteria for the Computational Analysis of Novel Drug Opportunities (CANDO) platform for shotgun drug repurposing to improve benchmarking performance, thereby enabling more accurate predict
Externí odkaz:
https://doaj.org/article/581cf70ccb2c4136ab61dbd24085871e
Autor:
Manoj J. Mammen, Chengjian Tu, Matthew C. Morris, Spencer Richman, William Mangione, Zackary Falls, Jun Qu, Gordon Broderick, Sanjay Sethi, Ram Samudrala
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 566 (2022)
Bronchoalveolar lavage of the epithelial lining fluid (BALF) can sample the profound changes in the airway lumen milieu prevalent in chronic obstructive pulmonary disease (COPD). We compared the BALF proteome of ex-smokers with moderate COPD who are
Externí odkaz:
https://doaj.org/article/e936a32dbaad4c84a331129c244743e7
Autor:
Lama Moukheiber, William Mangione, Mira Moukheiber, Saeed Maleki, Zackary Falls, Mingchen Gao, Ram Samudrala
Publikováno v:
Molecules, Vol 27, Iss 9, p 3021 (2022)
Humans are exposed to numerous compounds daily, some of which have adverse effects on health. Computational approaches for modeling toxicological data in conjunction with machine learning algorithms have gained popularity over the last few years. Mac
Externí odkaz:
https://doaj.org/article/4e35f93a57a240c680c57caa8d25fc94