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C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

Autor: Emerging Risk Factors Collaboration, Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, Danesh JTipping RW, Ford CE, Pressel SL, Walldius G, Jungner I, Folsom AR, Chambless L, Ballantyne CM, Panagiotakos D, Pitsavos C, Chrysohoou C, Stefanadis C, Knuiman MW, Goldbourt U, Benderly M, Tanne D, Whincup P, Wannamethee SG, Morris RW, Kiechl S, Willeit J, Mayr A, Schett G, Wald N, Ebrahim S, Lawlor D, Yarnell J, Gallacher J, Casiglia E, Tikhonoff V, Nietert PJ, Sutherland SE, Bachman DL, Keil JE, Cushman M, Psaty BM, Tracy R, Tybjaerg Hansen A, Nordestgaard BG, Zacho J, Frikke Schmidt R, Giampaoli S, Palmieri L, Vanuzzo D, Pilotto L, de la Cámara AG, Gerique JA, Simons L, McCallum J, Friedlander Y, Fowkes FG, Lee A, Taylor J, Guralnik JM, Phillips CL, Wallace RB, Blazer DG, Khaw KT, Brenner H, Raum E, Müller H, Rothenbacher D, Jansson JH, Wennberg P, Nissinen A, Donfrancesco C, Salomaa V, Harald K, Jousilahti P, Vartiainen E, Woodward M, D'Agostino RB, Wolf PA, Vasan RS, Benjamin EJ, Bladbjerg EM, Jørgensen T, Møller L, Jespersen J, Dankner R, Chetrit A, Lubin F, Rosengren A, Wilhelmsen L, Lappas G, Eriksson H, Björkelund C, Lissner L, Bengtsson C, Cremer P, Nagel D, Tilvis RS, Strandberg TE, Kiyohara Y, Arima H, Doi Y, Ninomiya T, Rodriguez B, Dekker J, Nijpels G, Stehouwer CD, Rimm E, Pai JK, Sato S, Iso H, Kitamura A, Noda H, Salonen JT, Nyyssönen K, Tuomainen TP, Laukkanen JA, Deeg DJ, Bremmer MA, Meade TW, Cooper JA, Hedblad B, Berglund G, Engström G, Verschuren WM, Blokstra A, Shea S, Döring A, Koenig W, Meisinger C, Bueno de Mesquita HB, Kuller LH, Grandits G, Selmer R, Tverdal A, Nystad W, Gillum RF, Mussolino M, Hankinson S, Manson JE, Knottenbelt C, Bauer KA, Davidson K, Kirkland S, Shaffer J, Korin MR, Naito Y, Holme I, Nakagawa H, Miura K, Ducimetiere P, Jouven X, Luc G, Crespo CJ, Garcia Palmieri MR, Amouyel P, Arveiler D, Evans A, Ferrieres J, Schulte H, Assmann G, Packard CJ, Sattar N, Westendorp RG, Buckley BM, Cantin B, Lamarche B, Després JP, Dagenais GR, Barrett Connor E, Wingard DL, Bettencourt RR, Gudnason V, Aspelund T, Sigurdsson G, Thorsson B, Trevisan M, Witteman J, Kardys I, Breteler MM, Hofman A, Tunstall Pedoe H, Tavendale R, Howard BV, Zhang Y, Best L, Umans J, Ben Shlomo Y, Davey Smith G, Onat A, Njølstad I, Mathiesen EB, Løchen ML, Wilsgaard T, Ingelsson E, Basu S, Cederholm T, Byberg L, Gaziano JM, Stampfer M, Ridker PM, Ulmer H, Diem G, Concin H, Tosetto A, Rodeghiero F, Wassertheil Smoller S, Marmot IM, Clarke R, Fletcher A, Brunner E, Shipley M, Buring J, Shepherd J, Cobbe S, Ford I, Robertson M, He Y, Ibañez AM, Feskens EJ, Walker M, Watson S, Erqou S, Lewington S, Pennells L, Perry PL, Ray KK, Sarwar N, Alexander M, Thompson A, White IR, Wood AM, Danesh J., PANICO, SALVATORE

Publikováno v: Lancet
Kaptoge, S, Di Angelantonio, E, Lowe, G, Pepys, M B, Thompson, S G, Collins, R, Danesh, J, Tipping, R W, Ford, C E, Pressel, S L, Walldius, G, Jungner, I, Folsom, A R, Chambless, L, Ballantyne, C M, Panagiotakos, D, Pitsavos, C, Chrysohoou, C, Stefanadis, C, Knuiman, M W, Goldbourt, U, Benderly, M, Tanne, D, Whincup, P, Wannamethee, S G, Morris, R W, Kiechl, S, Willeit, J, Mayr, A, Schett, G, Wald, N, Ebrahim, S, Lawlor, D, Yarnell, J, Gallacher, J, Casiglia, E, Tikhonoff, V, Nietert, P J, Sutherland, S E, Bachman, D L, Keil, J E, Cushman, M, Psaty, B M, Tracy, R, Tybjærg-Hansen, A, Nordestgaard, B G, Zacho, J, Frikke-Schmidt, R, Giampaoli, S, Palmieri, L, Panico, S, Vanuzzo, D, Pilotto, L, De La Cámara, A G, Gómez Gerique, J A, Simons, L, McCallum, J, Friedlander, Y, Fowkes, F G R, Lee, A, Taylor, J, Guralnik, J M, Phillips, C L, Wallace, R B, Blazer, D G, Khaw, K T, Brenner, H, Raum, E, Müller, H, Rothenbacher, D, Jansson, J H, Wennberg, P, Nissinen, A, Donfrancesco, C, Harald, K, Jousilahti, P, Vartiainen, E, Woodward, M, D’Agostino, R B, Wolf, P A, Vasan, R S, Rosengren, A, Bladbjerg, E M, Jørgensen, T, Møller, L, Jespersen, J, Dankner, R, Chetrit, A, Lubin, F, Rosengren, A, Wilhelmsen, L, Lappas, G, Eriksson, H, Björkelund, C, Lissner, L, Bengtsson, C, Cremer, P, Nagel, D, Tilvis, R S, Strandberg, T E, Kiyohara, Y, Arima, H, Doi, Y, Ninomiya, T, Rodriguez, B, Dekker, J, Nijpels, G, Stehouwer, C D A, Rimm, E, Pai, J K, Sato, S, Iso, H, Kitamura, A, Noda, H, Salonen, J T, Nyyssönen, K, Tuomainen, T P, Laukkanen, J A, Deeg, D J H, Bremmer, M A, Meade, T W, Cooper, J A, Hedblad, B, Berglund, G, Engström, G, Verschuren, W M M, Blokstra, A, Shea, S, Döring, A, Koenig, W, Meisinger, C, Bueno-De-Mesquita, H B, Kuller, L H, Grandits, G, Selmer, R, Tverdal, A, Nystad, W, Gillum, R F, Mussolino, M, Hankinson, S, Manson, J E, Knottenbelt, C, Bauer, K A, Davidson, K, Kirkland, S, Shaffer, J, Korin, M R, Naito, Y, Holme, I, Nakagawa, H, Miura, K, Ducimetiere, P, Jouven, X, Luc, G, Crespo, C J, Garcia-Palmieri, M R, Amouyel, P, Arveiler, D, Evans, A, Ferrieres, J, Schulte, H, Assmann, G, Packard, C J, Sattar, N, Westendorp, R G, Buckley, B M, Cantin, B, Lamarche, B, Després, J P, Dagenais, G R, Barrett-Connor, E, Wingard, D L, Bettencourt, R R, Gudnason, V, Aspelund, T, Sigurdsson, G, Thorsson, B, Trevisan, M, Witteman, J, Kardys, I, Breteler, M M B, Hofman, A, Tunstall-Pedoe, H, Tavendale, R, Howard, B V, Zhang, Y, Best, L, Umans, J, Ben-Shlomo, Y, Davey-Smith, G, Onat, A, Njølstad, I, Mathiesen, E B, Løchen, M L, Wilsgaard, T, Ingelsson, E, Basu, S, Cederholm, T, Byberg, L, Gaziano, J M, Stampfer, M, Ridker, P M, Ulmer, H, Diem, G, Concin, H, Tosetto, A, Rodeghiero, F, Wassertheil-Smoller, S, Marmot, M, Clarke, R, Fletcher, A, Brunner, E, Shipley, M, Buring, J, Shepherd, J, Cobbe, S, Ford, I, Robertson, M, He, Y, Marin Ibañez, A, Feskens, E J M, Walker, M, Watson, S, Erqou, S, Lewington, S, Pennells, L, Perry, P L, Ray, K K, Sarwar, N, Alexander, M, Thompson, A, White, I R & Wood, A M 2010, ' C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality : An individual participant meta-analysis ', The Lancet, vol. 375, no. 9709, pp. 132-140 . https://doi.org/10.1016/S0140-6736(09)61717-7
Lancet, 375(9709), 132-140
Lancet, 375(9709), 132-140. Elsevier Science
The Lancet, 375(9709), 132-140. Elsevier Limited
Kaptoge, S, Di Angelantonio, E, Lowe, G, Pepys, M B, Thompson, S G, Collins, R, Danesh, J, Bladbjerg, E-M, Jespersen, J & Ukendt, M F 2010, ' C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis ', Lancet, vol. 375, no. 9709, pp. 132-140 . https://doi.org/10.1016/S0140-6736(09)61717-7

Udgivelsesdato: 2010-Jan-9 BACKGROUND: Associations of C-reactive protein (CRP) concentration with risk of major diseases can best be assessed by long-term prospective follow-up of large numbers of people. We assessed the associations of CRP concentr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacbd15fa146c37482b24b8e3b1a7e4b
https://hdl.handle.net/1887/108460

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Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data

Autor: Wensley, F, Gao, P, Burgess, S, Kaptoge, S, Di Angelantonio, E, Shah, T, Engert, JC, Clarke, R, Davey-Smith, G, Nordestgaard, BG, Saleheen, D, Samani, NJ, Sandhu, M, Anand, S, Pepys, MB, Smeeth, L, Whittaker, J, Casas, JP, Thompson, SG, Hingorani, AD, Danesh, J, Eiriksdottir, G, Harris, TB, Launer, LJ, Gudnason, V, Folsom, AR, Andrews, G, Ballantyne, CM, Hall, AS, Braund, PS, Balmforth, AJ, Whincup, PH, Morris, R, Lawlor, DA, Lowe, GDO, Timpson, N, Ebrahim, S, Ben-Shlomo, Y, Tybjaerg-Hansen, A, Zacho, J, Brown, M, Ricketts, SL, Ashford, S, Lange, L, Reiner, A, Cushman, M, Tracy, R, Wu, C, Ge, J, Zou, Y, Sun, A, Hung, J, McQuillan, B, Thompson, P, Beilby, J, Warrington, N, Palmer, LJ, Wanner, C, Drechsler, C, Hoffmann, MM, Fowkes, FGR, Tzoulaki, I, Kumari, M, Miller, M, Marmot, M, Onland-Moret, C, van der Schouw, YT, Boer, JM, Wijmenga, C, Khaw, K-T, Vasan, RS, Schnabel, RB, Yamamoto, JF, Benjamin, EJ, Schunkert, H, Erdmann, J, Koenig, IR, Hengstenberg, C, Chiodini, B, Franzosi, MG, Pietri, S, Gori, F, Rudock, M, Liu, Y, Lohman, K, Humphries, SE, Hamsten, A, Norman, PE, Hankey, GJ, Jamrozik, K, Rimm, EB, Pai, JK, Psaty, BM, Heckbert, SR, Bis, JC, Yusuf, S, Xie, C, Collins, R, Bennett, D, Kooner, J, Chambers, J, Elliott, P, Maerz, W, Kleber, ME, Boehm, BO, Winkelmann, BR, Melander, O, Berglund, G, Koenig, W, Thorand, B, Baumert, J, Peters, A, Manson, J, Cooper, JA, Talmud, PJ, Ladenvall, P, Johansson, L, Jansson, J-H, Hallmans, G, Reilly, MP, Qu, L, Li, M, Rader, DJ, Watkins, H, Hopewell, J, Frossard, P, Sattar, N, Robertson, M, Shepherd, J, Schaefer, E, Hofman, A, Witteman, JCM, Kardys, I, Dehghan, A, de Faire, U, Bennet, A, Gigante, B, Leander, K, Peters, B, Maitland-van der Zee, AH, de Boer, A, Klungel, O, Greenland, P, Dai, J, Liu, S, Brunner, E, Kivimaki, M, O'Reilly, D, Ford, I, Packard, CJ, Dis, CRPCH, CIHDS, CC, CUPID, C

Publikováno v: The BMJ
British Medical Journal, 342:548. BMJ PUBLISHING GROUP
BMJ (Clinical research ed.), 342. British Medical Association

Objective To use genetic variants as unconfounded proxies of C reactive protein concentration to study its causal role in coronary heart disease. Design Mendelian randomisation meta-analysis of individual participant data from 47 epidemiological stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bfe6fa59bb57c55235f85e057c7e4cb
http://ora.ox.ac.uk/objects/uuid:e709a4c1-967b-4073-8223-ae1bf58309fe

Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables

Autor: Burgess, S, Thompson, SG, Andrews, G, Samani, NJ, Hall, A, Whincup, P, Morris, R, Lawlor, DA, Davey Smith, G, Timpson, N, Ebrahim, S, Ben-Shlomo, Y, Brown, M, Ricketts, S, Sandhu, M, Reiner, A, Psaty, B, Lange, L, Cushman, M, Hung, J, Thompson, P, Beilby, J, Warrington, N, Palmer, LJ, Nordestgaard, BG, Tybjaerg-Hansen, A, Zacho, J, Wu, C, Lowe, G, Tzoulaki, I, Kumari, M, Yamamoto, JF, Chiodini, B, Franzosi, M, Hankey, GJ, Jamrozik, K, Palmer, L, Rimm, E, Pai, J, Heckbert, S, Bis, J, Anand, S, Engert, J, Collins, R, Clarke, R, Melander, O, Berglund, G, Ladenvall, P, Johansson, L, Jansson, JH, Hallmans, G, Hingorani, A, Humphries, S, Manson, J, Watkins, H, Hopewell, J, Saleheen, D, Frossard, R, Danesh, J, Sattar, N, Robertson, M, Shepherd, J, Schaefer, E, Hofman, A, Witteman, JC, Kardys, I, de Faire, U, Bennet, A, Ford, I, Packard, C, Casas, JP, Smeeth, L, Wensley, F, Bowden, J, Di Angelantonio, E, Gao, P, Shah, T, Verzilli, C, Walker, M, Whittaker, J

Publikováno v: Statistics in medicine. 29(12)

Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d2c463e675972f76cbd260c2f72e534
http://ora.ox.ac.uk/objects/uuid:ab9c7cd0-4061-49b0-8287-75771e76786b