Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Zachery Mielko"'
Autor:
Zachery Mielko, Yuning Zhang, Harshit Sahay, Yiling Liu, Matthew A. Schaich, Brittani Schnable, Abigail M. Morrison, Debbie Burdinski, Sheera Adar, Miles Pufall, Bennett Van Houten, Raluca Gordân, Ariel Afek
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Somatic mutations are highly enriched at transcription factor (TF) binding sites, with the strongest trend being observed for ultraviolet light (UV)-induced mutations in melanomas. One of the main mechanisms proposed for this hypermutation pattern is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4aee09ad67b0c92117e66ac6e464c0
https://doi.org/10.1073/pnas.2217422120
https://doi.org/10.1073/pnas.2217422120
QBiC-Pred: quantitative predictions of transcription factor binding changes due to sequence variants
Publikováno v:
Nucleic Acids Research
Non-coding genetic variants/mutations can play functional roles in the cell by disrupting regulatory interactions between transcription factors (TFs) and their genomic target sites. For most human TFs, a myriad of DNA-binding models are available and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cbe74500f7dd55023edeaa202180ad
https://doi.org/10.1093/nar/gkz363
https://doi.org/10.1093/nar/gkz363
Autor:
Anat Shahar, Ariel Afek, Oshrit Ben-David, Zachery Mielko, Raz Zarivach, Yael Belo, Hila Nudelman, Raluca Gordan, Eyal Arbely
Publikováno v:
Biochim Biophys Acta Gen Subj
The signal transducer and activator of transcription 3 (STAT3) protein is activated by phosphorylation of a specific tyrosine residue (Tyr705) in response to various extracellular signals. STAT3 activity was also found to be regulated by acetylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dfae8094ecd15a8409146fa92f50ee
https://doi.org/10.1101/537696
https://doi.org/10.1101/537696
Autor:
Raul E. Salinas, Gregory M.K. Poon, Mimi Fang, Zachery Mielko, Suela Xhani, Alon Senitzki, Hashim M. Al-Hashimi, Maria A. Schumacher, Miles A. Pufall, Atul Rangadurai, Tali E. Haran, Honglue Shi, Raluca Gordân, Harshit Sahay, Ariel Afek
Publikováno v:
Nature
Transcription factors recognize specific genomic sequences to regulate complex gene-expression programs. Although it is well-established that transcription factors bind to specific DNA sequences using a combination of base readout and shape recogniti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1e7de883a8dab8a462a4549cee163b
https://pubmed.ncbi.nlm.nih.gov/33087865
https://pubmed.ncbi.nlm.nih.gov/33087865