Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zachary Waldrip"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 7-7 (2021)
ABSTRACT IMPACT: This work provides supporting evidence for the development of a novel immunosuppression therapy for transplant patients. OBJECTIVES/GOALS: Our laboratory reported that inhibition of the kinase DNA-PK(cs) in mice delays allogeneic gra
Externí odkaz:
https://doaj.org/article/3bf5567639314c6b95805e7a63a30ed2
Autor:
Marie Burdine, Ana Azevedo-Pouly, Lauren Appell, Melanie Barker, Zachary Waldrip, Lyle Burdine
Publikováno v:
The Journal of Immunology. 208:55.15-55.15
Antigen-mediated activation of naïve CD8+ T cells and their differentiation into cytotoxic cells is regulated by a series of signaling mechanisms designed to maintain T cell homeostasis and proper immune responses. Given that cytotoxic CD8+ T cells
Publikováno v:
The Journal of Immunology. 206:28.15-28.15
Background: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure. DNA-dependent protein kinase catalytic
Publikováno v:
The Journal of Immunology. 204:161.23-161.23
Organ transplantation is the only option for patients in end-stage organ failure. Therefore; it is imperative that immunological mechanisms that foster graft rejection be elucidated to develop more effective immunosuppressants for transplant patients
Publikováno v:
The Journal of Immunology. 202:69.26-69.26
While the number of patients needing solid organ transplants has steadily increased over the years, the development of safer, more effective transplant drugs has stagnated. Current therapy has been largely successful at thwarting acute cellular rejec