Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zachary W Veitch"'
Autor:
Esmail M Al-Ezzi, Zachary W Veitch, Samer H Salah, Theodorus H Van der Kwast, Tracy L Stockley, Shamini Selvarajah, Tong Zhang, Srikala S Sridhar, Adrian G Sacher, Nazanin Fallah-Rad, Girish S Kulkarni, Alexandre R Zlotta, Antonio Finelli, Aaron R Hansen
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0259272 (2021)
BackgroundNon-schistosomiasis related-squamous cell carcinoma of urinary bladder (NSR-SCCUB) is a rare tumor subtype distinct from urothelial carcinoma (UC). Studies assessing molecular biomarkers in bladder cancer have generally focused on UC, and g
Externí odkaz:
https://doaj.org/article/e3799ed33ecf4271a5cb805e2c0260da
Autor:
Esmail Al-Ezzi, Abhenil Mittal, Zachary W. Veitch, Amer Zahralliyali, Nely Mercy Diaz Mejia, Osama Abdeljalil, Husam Alqaisi, Vikaash Kumar, Aaron R. Hansen, Nazanin Fallah-Rad, Srikala S. Sridhar
Publikováno v:
Journal of Kidney Cancer and VHL, Vol 11, Iss 1 (2024)
Immunotherapy (IO) with or without targeted therapy (TT) is the standard treatment for patients with metastatic clear cell renal cell carcinoma (RCC). The evidence supporting their use in metastatic nonclear cell renal cell carcinoma (nccRCC) subtype
Externí odkaz:
https://doaj.org/article/b7d3d94769e84d84a091c0eecef9f662
Autor:
John Hilton, Karen Gelmon, Philippe L. Bedard, Dongsheng Tu, Hong Xu, Anna V. Tinker, Rachel Goodwin, Scott A. Laurie, Derek Jonker, Aaron R. Hansen, Zachary W. Veitch, Daniel J. Renouf, Linda Hagerman, Hongbo Lui, Bingshu Chen, Deb Kellar, Irene Li, Sung-Eun Lee, Takako Kono, Brian Y. C. Cheng, Damian Yap, Daniel Lai, Sean Beatty, John Soong, Kathleen I. Pritchard, Isabel Soria-Bretones, Eric Chen, Harriet Feilotter, Moira Rushton, Lesley Seymour, Samuel Aparicio, David W. Cescon
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
G-quadruplex stabilizers, including CX-5461, exhibit synthetic lethality with loss of BRCA1/2 in preclinical models. Here the authors report the results of a phase I study of CX-5461 in patients with solid tumors enriched for DNA-repair deficiencies.
Externí odkaz:
https://doaj.org/article/ee095627571b4e258e1890f77d3d7597
Autor:
Husam A. Alqaisi, Carlos Stecca, Zachary W. Veitch, Jamila Riromar, Jeenan Kaiser, Nazanin Fallah-Rad, Di Maria Jiang, Scott North, Sunil Samnani, Nimira Alimohamed, Srikala S. Sridhar
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 14 (2022)
Background: In metastatic urothelial cancer (mUC), bone metastasis (BM) are associated with significant morbidity and mortality, yet their role as an independent prognostic variable remains unclear. We aimed to determine the impact of BM on overall s
Externí odkaz:
https://doaj.org/article/09c2af7facc04086bb1a915a240fde56
Autor:
Geoffrey A. Watson, Zachary W. Veitch, Daniel Shepshelovich, Zhihui Amy Liu, Anna Spreafico, Albiruni R. Abdul Razak, Philippe L. Bedard, Lillian L. Siu, Lori Minasian, Aaron R. Hansen
Publikováno v:
British journal of cancer. 127(9)
Adverse event (AE) reporting in early-phase clinical trials is essential in determining the tolerability of experimental anticancer therapies. The patient-reported outcome version of the CTCAE (PRO-CTCAE) evaluates AE components such as severity and
Autor:
Stacey L. Hembruff, Jamei Eng, Zachary W. Veitch, Baoqing Guo, Stephanie Cull, David A. MacLean, Adam J. Bewick, Allan D. Heibein, Amadeo M. Parissenti
Publikováno v:
Pharmacogenetics and Genomics. 19:477-488
Recent studies suggest that tumor cells overexpressing aldoketoreductases (AKRs) exhibit increased resistance to DNA damaging agents such as anthracyclines. AKRs may induce resistance to the anthracycline doxorubicin by catalyzing its conversion to t
Autor:
Domen Ribnikar, Hadar Goldvaser, Zachary W. Veitch, Alberto Ocana, Arnoud J. Templeton, Boštjan Šeruga, Eitan Amir
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Data suggest that for newly approved cancer drugs safety and tolerability are worse than in control arms of registration trials. Less is known about the balance between efficacy and toxicity of drugs studied in unselected phase 3 randomized
Externí odkaz:
https://doaj.org/article/1b46992acee94202aa4a2afa74817e81