Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary W, Dwyer"'
Autor:
Zachary W. Dwyer, Jeffrey A. Pleiss
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-5 (2023)
In this comment, the authors discuss the potentially widespread problem of selection bias in drawing biological conclusions from RNA sequencing data.
Externí odkaz:
https://doaj.org/article/770abe4034c34a1b9ca1e7144d0001c0
Publikováno v:
Molecular Cell. 82:2967-2981.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a36b2be0053685473a5aa36ed47b69
https://doi.org/10.1016/j.molcel.2022.06.020
https://doi.org/10.1016/j.molcel.2022.06.020
SummaryUnderstanding how the spliceosome processes its composite of substrates through the two chemical steps required for mRNA production will be essential to deciphering splicing regulation and mis-regulation. Here we measure the in vivo rates of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99446ee1651092bd89d87881256b089c
https://doi.org/10.1101/2020.10.13.338152
https://doi.org/10.1101/2020.10.13.338152
Publikováno v:
Molecular cell. 82(16)
We generate high-precision measurements of the in vivo rates of both chemical steps of pre-mRNA splicing across the genome-wide complement of substrates in yeast by coupling metabolic labeling, multiplexed primer-extension sequencing, and kinetic mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b7c68917a2b568d615d2a6270ba10c6
https://pubmed.ncbi.nlm.nih.gov/35830855
https://pubmed.ncbi.nlm.nih.gov/35830855
Publikováno v:
Nature methods
Targeted RNA sequencing (RNA-seq) aims to focus coverage on areas of interest that are inadequately sampled in standard RNA-seq experiments. Here we present multiplexed primer extension sequencing (MPE-seq), an approach for targeted RNA-seq that uses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48b0e56484eb2631debaa45613d2dbf
https://doi.org/10.1038/s41592-018-0258-x
https://doi.org/10.1038/s41592-018-0258-x
Publikováno v:
Methods
The study of pre-mRNA splicing has been greatly aided by the advent of RNA sequencing (RNA-seq), which enables the genome-wide detection of discrete splice isoforms. Quantification of these splice isoforms requires analysis of splicing informative se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68b039073dc6fe9b3548fb070654be1
https://pubmed.ncbi.nlm.nih.gov/31121301
https://pubmed.ncbi.nlm.nih.gov/31121301
Autor:
Maki Inada, Zachary W. Dwyer, Jelani Akil Williams, Amy Larson, Jeffrey A. Pleiss, Benjamin Jung Fair
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac3b95bddc385dea6c1f7c8977df2df
https://doi.org/10.1096/fasebj.2020.34.s1.04400
https://doi.org/10.1096/fasebj.2020.34.s1.04400
Autor:
Craig Altier, Jonathan G. Frye, Sara D. Lawhon, James M. Slauch, Brian M. M. Ahmer, Michael McClelland, Zachary W. Dwyer, Cherilyn D. Garner, Chien Che Hung
Publikováno v:
Molecular Microbiology. 87:1045-1060
Summary To cause disease, Salmonella must invade the intestinal epithelium employing genes encoded within Salmonella Pathogenicity Island 1 (SPI1). We show here that propionate, a fatty acid abundant in the intestine of animals, repressed SPI1 at phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23ffa2cf17fa27b1e44c977574440c2
https://doi.org/10.1111/mmi.12149
https://doi.org/10.1111/mmi.12149
Publikováno v:
Molecular cell. 53(5)
Abnormal metabolism and sustained proliferation are hallmarks of cancer. Pyruvate kinase M2 (PKM2) is a metabolic enzyme that plays important roles in both processes. Recently, PKM2 was shown to have protein kinase activity phosphorylating histone H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0356e972eff2f153d5f9776e725f8e7
https://pubmed.ncbi.nlm.nih.gov/24606916
https://pubmed.ncbi.nlm.nih.gov/24606916
Autor:
Chien-Che, Hung, Cherilyn D, Garner, James M, Slauch, Zachary W, Dwyer, Sara D, Lawhon, Jonathan G, Frye, Michael, McClelland, Brian M M, Ahmer, Craig, Altier
Publikováno v:
Molecular microbiology. 87(5)
To cause disease, Salmonella must invade the intestinal epithelium employing genes encoded within Salmonella Pathogenicity Island 1 (SPI1). We show here that propionate, a fatty acid abundant in the intestine of animals, repressed SPI1 at physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::010661a42bfc9cb627e01be6509dac32
https://pubmed.ncbi.nlm.nih.gov/23289537
https://pubmed.ncbi.nlm.nih.gov/23289537