Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary T. Britton"'
Publikováno v:
Methods. 180:111-126
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer by multiple transmembrane spanning helices, encompass families of proteins which are important target classes for drug discovery. These protein families include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853ae41aab44e96dc6fdd25d2569eae1
https://doi.org/10.1016/j.ymeth.2020.05.006
https://doi.org/10.1016/j.ymeth.2020.05.006
Publikováno v:
Protein engineering, designselection : PEDS. 32(10)
The tachykinin 2 receptor (NK2R) plays critical roles in gastrointestinal, respiratory and mental disorders and is a well-recognized target for therapeutic intervention. To date, therapeutics targeting NK2R have failed to meet regulatory agency appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9937d1152731ccb94d7f59c2f4abf4
https://pubmed.ncbi.nlm.nih.gov/32400863
https://pubmed.ncbi.nlm.nih.gov/32400863
Autor:
Michael A. Bowen, Timothy B. C. London, William Dall'acqua, Trevor Wilkinson, Zachary T Britton, Herren Wu, Bhupinder Dosanjh, Marcello Marelli, Yariv Mazor, Jeffrey Carrell
Publikováno v:
Protein engineering, designselection : PEDS. 31(10)
Membrane proteins play key roles in the evolution of numerous diseases and as a result have become the most dominant class of targets for therapeutic intervention. However, their poor expression and detection oftentimes prohibit drug discovery and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4113ba503b5564166b8abc4674d13c63
https://pubmed.ncbi.nlm.nih.gov/30753634
https://pubmed.ncbi.nlm.nih.gov/30753634
Publikováno v:
Biotechnology Journal. 7:620-634
Protein fusion tags are indispensible tools used to improve recombinant protein expression yields, enable protein purification, and accelerate the characterization of protein structure and function. Solubility-enhancing tags, genetically engineered e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cea2988b51a54f7bf3695fbd2fd476c
https://doi.org/10.1002/biot.201100155
https://doi.org/10.1002/biot.201100155
Autor:
Kory M, Blocker, Zachary T, Britton, Andrea N, Naranjo, Patrick M, McNeely, Carissa L, Young, Anne S, Robinson
Publikováno v:
Methods in enzymology. 556
G protein-coupled receptors (GPCRs) are membrane proteins that mediate signaling across the cellular membrane and facilitate cellular responses to external stimuli. Due to the critical role that GPCRs play in signal transduction, therapeutics have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1730267c73abdd0a8429ed1b0fbe0d9d
https://pubmed.ncbi.nlm.nih.gov/25857782
https://pubmed.ncbi.nlm.nih.gov/25857782
Autor:
Patrick M. McNeely, Kory M. Blocker, Carissa L. Young, Anne S. Robinson, Andrea N. Naranjo, Zachary T. Britton
G protein-coupled receptors (GPCRs) are membrane proteins that mediate signaling across the cellular membrane and facilitate cellular responses to external stimuli. Due to the critical role that GPCRs play in signal transduction, therapeutics have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91605c86786fbd845214f2339f0722d9
https://doi.org/10.1016/bs.mie.2014.12.025
https://doi.org/10.1016/bs.mie.2014.12.025
Publikováno v:
Annals of Biomedical Engineering. 34:653-659
This study determines the differences in proliferation, collagen production, alpha-smooth muscle actin (alpha-SMA) expression, and contraction between healing and normal fibroblasts. Transected and sham-operated rat medial collateral ligaments (MCL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d47898168cdfc8466fe863bf37f827f
https://doi.org/10.1007/s10439-006-9090-z
https://doi.org/10.1007/s10439-006-9090-z
Publikováno v:
Protein expression and purification. 84(2)
Biophysical and structural characterization of G protein-coupled receptors (GPCRs) has been limited due to difficulties in expression, purification, and vitro stability of the full-length receptors. "Divide and conquer" approaches aimed at the NMR ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c9a48ba14864f7f86fa25fa967f1383
https://pubmed.ncbi.nlm.nih.gov/22722102
https://pubmed.ncbi.nlm.nih.gov/22722102
Publikováno v:
Biophysical Journal. 100(3)
Despite the role of G-protein-coupled receptors (GPCRs), the largest family of integral membrane proteins, in various physiological processes and significant interest by the pharmaceutical industry, our knowledge of this class of proteins is limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804163d3a86a1b5342bee7064d2143ea
The G-protein coupled receptors (GPCRs) are a class of membrane proteins that trigger cellular responses to external stimuli, and are believed to be targets for nearly half of all pharmaceutical drugs on the market. However, little is known regarding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f448e304b8f960376d9c189142866e
https://europepmc.org/articles/PMC1994815/
https://europepmc.org/articles/PMC1994815/