Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Zachary S. Stewart"'
Autor:
Brett D. Hollingshead, Anna K. Kopec, Yutian Zhan, Timothy P. LaBranche, John W. Davis, Kyle Hayes, Srinivasa R. Mantena, Andrew W. Harrington, Laurence O. Whiteley, Zachary S. Stewart, Andrew D. Burdick
Publikováno v:
Toxicologic Pathology. 48:994-1007
Fatty liver disease is a potential risk factor for drug-induced liver injury (DILI). Despite advances in nonclinical in vitro and in vivo models to assess liver injury during drug development, the pharmaceutical industry is still plagued by idiosyncr
Autor:
Mina Hassan-Zahraee, Michael S. Vincent, Julie Lee, Mateusz Maciejewski, Vivek Pradhan, Shanrong Zhao, Yutian Zhan, David von Schack, Huanyu Zhou, Kenneth J. Gorelick, Zachary S. Stewart, Lori Fitz, Shawn P. O'Neil, Ying Zhang, Austin Huang, Li Xi, Karen Page, Kenneth E. Hung, Daniel Ziemek, Fabio Cataldi, Baohong Zhang
Publikováno v:
Journal of Crohn's & Colitis
Background and Aims To define pharmacodynamic and efficacy biomarkers in ulcerative colitis [UC] patients treated with PF-00547659, an anti-human mucosal addressin cell adhesion molecule-1 [MAdCAM-1] monoclonal antibody, in the TURANDOT study. Method
Publikováno v:
Current protocols in toxicology. 76(1)
Cellular development and homeostasis are regulated via programmed cell death (PCD; apoptosis), which is a genetically regulated cellular process. Accidental cell death (ACD; necrosis) can be triggered by chemical, physical, or mechanical stress. Necr
Autor:
Srinivasa R. Mantena, Cynthia M. Rohde, Dean Messing, Sharon A. Sokolowski, John W. Davis, Michael I. Jesson, Karrie A. Brenneman, Shawn P. O'Neil, Lindsay Tomlinson, Christopher G. Leonard, Laurence O. Whiteley, Steven Bailey, Deborah C. Carraher, Walter F. Bobrowski, Zachary S. Stewart, Yutian Zhan, W. Mark Vogel, Kimberly M. Shevlin, Dale L. Morris, Hungyun Lin, Shashi K. Ramaiah, Lauren M. Gauthier
Publikováno v:
Toxicologic Pathology. 42:229-242
Pancreatic toxicity commonly affects the endocrine or exocrine pancreas. However, it can also occur at the endocrine–exocrine interface (EEI), where the capillary network of the islet merges with the capillaries of the surrounding acinar tissue, th
Autor:
Dean Wilkie, Chris S. Bollinger, Nandini Kishore, Peter T. Symanowicz, Martin Hegen, Richard D. Head, Fernando A. Happa, Zaher A. Radi, Zachary S. Stewart, Sheri L. Bonar, Jeremy W. Wellen, Yutian Zhan, Janice M. Thompson, Timothy P. LaBranche, Michael I. Jesson, Prashant N. Bansal, Steven Bailey, Debra M. Meyer, Gabriel Mbalaviele, Julia A. Guzova, Chad E. Storer
Publikováno v:
Arthritis & Rheumatism. 64:3531-3542
Objective The mechanistic link between Janus kinase (JAK) signaling and structural damage to arthritic joints in rheumatoid arthritis (RA) is poorly understood. This study was undertaken to investigate how selective inhibition of JAK with tofacitinib
Publikováno v:
Toxicologic Pathology. 41:32-37
Renal tubular inclusion bodies are rarely associated with drug administration. The authors describe the finding of renal cortical tubular intranuclear and intracytoplasmic inclusion bodies associated with the oral administration of a norepinephrine/s
Publikováno v:
Current Protocols in Toxicology. 76:e51
Cellular development and homeostasis are regulated via programmed cell death (PCD; apoptosis), which is a genetically regulated cellular process. Accidental cell death (ACD; necrosis) can be triggered by chemical, physical, or mechanical stress. Necr
Autor:
Joseph Paulauskis, Zachary S. Stewart, Robert W. Dunstan, Peter J. Korytko, Carrie L. Schray, Kanwar Nasir M. Khan, Chandra N. Luster, Melissa L. Cox
Publikováno v:
Experimental and Molecular Pathology. 80:183-191
Molecular characterization of morphologic change requires exquisite tissue morphology and RNA preservation; however, traditional fixatives usually result in fragmented RNA. To optimize molecular analyses on fixed tissues, we assessed morphologic and
Autor:
Ben S. Zweifel, Gary D. Anderson, Robert A. Pufahl, Jaime L. Masferrer, Luz A. Cortes-Burgos, Dana E. Weir, Steven L. Settle, Matthew J. Graneto, Medora M. Hardy, Zachary S. Stewart, Fernando A. Happa, Shanmugam Muthian, George Hu
Publikováno v:
European journal of pharmacology. 617(1-3)
Zileuton, a redox and iron chelator 5-lipoxygenase (5-LOX) inhibitor and, leukotriene receptor antagonists are presently used clinically in the long term treatment of asthma. Recent data implicate 5-LOX pathway in pain signaling. We report 5-LOX expr
Autor:
Joseph Paulauskis, Robert W. Dunstan, Susan Eddy, Zachary S. Stewart, Maggi R. Kennel, Melissa L. Cox, Michael Z. Man
Publikováno v:
Experimental and molecular pathology. 84(2)
Described herein is a detailed analysis of the impact of three fixatives (10% neutral buffered formalin, modified methacarn and 70% ethanol) on RNA quality and utility using microarray analysis compared to OCT-embedded and flash frozen tissue. From r