Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary S. Sales"'
Autor:
Brett D. Allison, Xiaohu Deng, Lian-Sheng Li, Jimmy Liang, Neelakandha S. Mani, Pingda Ren, Zachary S. Sales
Publikováno v:
Organic Process Research & Development. 26:2926-2936
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ba0a62c2e60a2b422f684d47da8f72
https://doi.org/10.1021/acs.oprd.2c00242
https://doi.org/10.1021/acs.oprd.2c00242
Publikováno v:
The Journal of organic chemistry. 87(21)
We report a diastereoselective, photocatalyst-free decarboxylative alkylation of (hetero)aryl sulfinimines using redox-active esters under blue light. High yields and diastereoselectivities can be achieved under mild conditions, and we demonstrate it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb258e89c1478d7e2862f57e8a8c9e8
https://pubmed.ncbi.nlm.nih.gov/36228170
https://pubmed.ncbi.nlm.nih.gov/36228170
Publikováno v:
Bioorganicmedicinal chemistry. 73
We describe practical methods to prepare DOTAGA-DBCO and DFO-DBCO from commercially available starting materials. DOTAGA-DBCO is available in five steps from cyclen with a 33 % overall yield at gram scale. Our synthesis of DFO-DBCO also proceeds in f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effe5f4a4721f8bd1c599b39f454ad83
https://pubmed.ncbi.nlm.nih.gov/36126444
https://pubmed.ncbi.nlm.nih.gov/36126444
Publikováno v:
Tetrahedron Letters. 59:1623-1626
A new method for the preparation of 2-amino-4(3H)-quinazolinones and similar fused heterocycles is described. Simply warming a mixture of an aryl guanidine and carbonyl diimidazole in acetonitrile results in formation of a putative N-amidinoisocyanat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6cbfccb62495efcecc98590f637bb16
https://doi.org/10.1016/j.tetlet.2018.03.034
https://doi.org/10.1016/j.tetlet.2018.03.034
Autor:
Brian Lord, Jason C. Rech, Brian Scott, Kirsten L. Morton, Nicholas I. Carruthers, Victor Contreras, Natalie A. Hawryluk, Qi Wang, Xiaohui Jiang, Francois Paul Bischoff, Michael A. Letavic, Alan D. Wickenden, Pascal Bonaventure, Hong Ao, Serge Maria Aloysius Pieters, Zachary S. Sales, Anindya Bhattacharya, Adriana Ingrid Velter
Publikováno v:
ACS Medicinal Chemistry Letters. 4:419-422
The synthesis and preclinical characterization of two novel, brain penetrating P2X7 compounds will be described. Both compounds are shown to be high potency P2X7 antagonists in human, rat, and mouse cell lines and both were shown to have high brain c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c778658858962a1ac276dc8d4cd5e98
https://doi.org/10.1021/ml400040v
https://doi.org/10.1021/ml400040v
Autor:
Roger Faessler, Armin Roessler, Xiaohu Deng, Ivana Brdar, Neelakandha S. Mani, Zachary S. Sales, Jiejun Wu
Publikováno v:
The Journal of Organic Chemistry. 76:8262-8269
A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9502b07263333af0badef9203bcfa7ca
https://doi.org/10.1021/jo201425q
https://doi.org/10.1021/jo201425q
Publikováno v:
Journal of Organometallic Chemistry. 690:3474-3478
The equimolar reaction between Me3Al and the methyl ketones (2,4,6-R3–C6H2)C(O)CH3, where R = Me or iPr, results in exclusive formation of the enolization products [{Me2AlOC(2,4,6-R3–C6H2) CH2}2], 1 and 2, upon heating to reflux temperature in to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7100a869f1db8277d353bd0a980bd410
https://doi.org/10.1016/j.jorganchem.2005.04.040
https://doi.org/10.1016/j.jorganchem.2005.04.040
Autor:
Neelakandha S. Mani, Zachary S. Sales
Publikováno v:
ChemInform. 40
A novel intramolecular 1,3-dipolar cycloaddition strategy for a rapid entry into benzofuropyrazoles is described. In a three-step sequence, (E)-2-(1,2-dichlorovinyloxy)aryldiazomethanes were generated in situ from the corresponding salicylaldehydes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41cd8f56354034637c57b4925add9803
https://doi.org/10.1002/chin.200921119
https://doi.org/10.1002/chin.200921119
Autor:
Neelakandha S. Mani, Zachary S. Sales
Publikováno v:
The Journal of organic chemistry. 74(2)
A novel intramolecular 1,3-dipolar cycloaddition strategy for a rapid entry into benzofuropyrazoles is described. In a three-step sequence, (E)-2-(1,2-dichlorovinyloxy)aryldiazomethanes were generated in situ from the corresponding salicylaldehydes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31d25e853dbca6a127ff0c52fe56b29
https://pubmed.ncbi.nlm.nih.gov/19053198
https://pubmed.ncbi.nlm.nih.gov/19053198
Autor:
Neelakandha S. Mani, Jing Liu, Hariharan Venkatesan, Xiaohu Deng, Anne E. Fitzgerald, Zachary S. Sales
Publikováno v:
Organic & Biomolecular Chemistry. 9:2654
In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36d32596d47e82b62771920c94991d8
https://doi.org/10.1039/c0ob01004a
https://doi.org/10.1039/c0ob01004a