Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zachary R. Churcher"'
Autor:
Sladjana Slavkovic, Aron A. Shoara, Zachary R. Churcher, Elise Daems, Karolien de Wael, Frank Sobott, Philip E. Johnson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Artemisinin (ART) is a vital medicinal compound that is used alone or as part of a combination therapy against malaria. ART is thought to function by attaching to heme covalently and alkylating a range of proteins. Using a combination of bio
Externí odkaz:
https://doaj.org/article/60c0d68d386343b89f127425aca8f5b3
Publikováno v:
ACS Omega, Vol 6, Iss 37, Pp 24209-24217 (2021)
Externí odkaz:
https://doaj.org/article/5d6d6cc3fec549ef9ea77602503d4c8b
Autor:
Erfan Rahbarimehr, Hoi Pui Chao, Zachary R. Churcher, Sladjana Slavkovic, Yunus A. Kaiyum, Philip E. Johnson, Philippe Dauphin-Ducharme
Publikováno v:
Analytical Chemistry. 95:2229-2237
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39d4591848053b4fff900bc727646f95
https://doi.org/10.1021/acs.analchem.2c03566
https://doi.org/10.1021/acs.analchem.2c03566
Autor:
Philippe Dauphin‐Ducharme, Zachary R. Churcher, Aron A. Shoara, Erfan Rahbarimehr, Sladjana Slavkovic, Nicolas Fontaine, Olivia Boisvert, Philip E. Johnson
Publikováno v:
Chemistry – A European Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd2ee92fb00527a7a8a23fc156c76ed
https://doi.org/10.1002/chem.202300618
https://doi.org/10.1002/chem.202300618
Publikováno v:
ACS Omega, Vol 6, Iss 37, Pp 24209-24217 (2021)
Levamisole is a common and harmful adulterant of street samples of cocaine and can cause electrochemical tests for cocaine to give false negative results. To see if levamisole would interfere with aptamer-based bioassays, we analyzed the binding of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098451e78ebff2debd383ceb87fa9a9a
https://doi.org/10.1021/acsomega.1c03781
https://doi.org/10.1021/acsomega.1c03781
Autor:
Richard A. Manderville, Sladjana Slavkovic, Philip E. Johnson, Abigail J Van Riesen, Aron A. Shoara, Zachary R. Churcher, Jennifer Le
Publikováno v:
ACS Applied Bio Materials. 4:6732-6741
DNA three-way junctions (3WJs) consist of a Y-shaped hydrophobic branch point connecting three double-stranded stems and are viewed as druggable targets for cancer treatment. They are also important building blocks for the construction of DNA nanostr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1068ae55172459bca998a2888495efa
https://doi.org/10.1021/acsabm.1c00431
https://doi.org/10.1021/acsabm.1c00431
Publikováno v:
Biophys J
We have used magnetization transfer NMR experiments to measure the exchange rate constant (kex) of the imino protons in the unbound, cocaine-bound, and quinine-bound forms of the cocaine-binding DNA aptamer. Both long-stem 1 (MN4) and short-stem 1 (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb8ef80909a9604b45de9dc643962f3
https://doi.org/10.1016/j.bpj.2020.08.012
https://doi.org/10.1016/j.bpj.2020.08.012
Autor:
Abigail J. Van Riesen, Baylie Kalnitsky, Aron A. Shoara, Sladjana Slavkovic, Zachary R. Churcher, Philip E. Johnson, Richard A. Manderville
Publikováno v:
Dyes and Pigments. 209:110936
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3195c52ccf3afcf3724ebf6626740d2a
https://doi.org/10.1016/j.dyepig.2022.110936
https://doi.org/10.1016/j.dyepig.2022.110936
Autor:
Sladjana Slavkovic, Anne E. Johnson, Yanrui Zhu, Philip E. Johnson, Aron A. Shoara, Zachary R. Churcher
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The ATP-binding DNA aptamer is often used as a model system for developing new aptamer-based biosensor methods. This aptamer follows a structure-switching binding mechanism and is unusual in that it binds two copies of its ligand. We have used isothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202d97355518d4fbb395d519140164c7
https://doi.org/10.1038/s41598-020-76002-8
https://doi.org/10.1038/s41598-020-76002-8
Publikováno v:
Journal of Biomolecular NMR. 68:33-39
Using NMR magnetization transfer experiments, the hydrogen exchange rate constants (k ex ) of the DNA imino protons in the cocaine-binding aptamer have been determined for the free, cocaine-bound, and quinine-bound states. The secondary structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3fbc9d54665e35f44b2aa661a86914
https://doi.org/10.1007/s10858-017-0112-y
https://doi.org/10.1007/s10858-017-0112-y