Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zachary Mirman"'
Publikováno v:
Cell Cycle. 22:379-389
DNA double-strand breaks (DSBs) pose a major threat to the genome, so the efficient repair of such breaks is essential. DSB processing and repair is affected by 53BP1, which has been proposed to determine repair pathway choice and/or promote repair f
Publikováno v:
Nature Cell Biology. 24:51-61
Publikováno v:
DNA repair. 113
Double-strand break (DSB) repair relies on DNA damage response (DDR) factors including BRCA1, BRCA2, and RAD51, which promote homology-directed repair (HDR); 53BP1, which affects single-stranded DNA formation; and proteins that mediate end-joining. H
Publikováno v:
DNA Repair. 113:103320
Autor:
Zachary Mirman, Titia de Lange
53BP1 is an enigmatic DNA damage response factor that gained prominence because it determines the efficacy of PARP1 inhibitory drugs (PARPi) in BRCA1-deficient cancers. Recent studies have elevated 53BP1 from its modest status of (yet another) DNA da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cad49d6fcc9fee402c3133b5ddbaf6
https://europepmc.org/articles/PMC6938671/
https://europepmc.org/articles/PMC6938671/
Autor:
Francisca Lottersberger, Daniel Durocher, Tatsuya Kibe, Kaori K. Takai, Titia de Lange, Hiroyuki Takai, Alessandro Bianchi, Michal Zimmermann, Zachary Mirman, Yi Gong
Publikováno v:
Nature
In DNA repair, the resection of double-strand breaks dictates the choice between homology-directed repair—which requires a 3′ overhang—and classical non-homologous end joining, which can join unresected ends1,2. BRCA1-mutant cancers show minima
Publikováno v:
Dev Cell
Summary Epithelial cells dynamically self-organize in response to extracellular spatial cues relayed by cell-surface receptors. During convergent extension in Drosophila, Toll-related receptors direct planar polarized cell rearrangements that elongat
Autor:
Adam C. Paré, Athea Vichas, Christopher T. Fincher, Zachary Mirman, Dene L. Farrell, Avantika Mainieri, Jennifer A. Zallen
Publikováno v:
Nature. 527:398-398