Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Zachary M. Sandusky"'
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100270- (2021)
Summary: A FACS protocol is described that eliminates isolation and staining artifacts to allow accurate comparison between cell populations isolated from organs obtained from disparate mouse groups. This protocol was validated by characterizing the
Externí odkaz:
https://doaj.org/article/312d549c52364b15862dbe7d55cdb96f
Autor:
Deborah A. Lannigan, George A. O'Doherty, Jennifer A. Pietenpol, David R. Brenin, Miranda E. Sowder, Lejla Pasic, Zachary M. Sandusky, Yu Li, Mingzong Li, J. Preston Campbell, Katarzyna A. Ludwik
Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream MEK-ERK1/2 effector,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1112720a72a8ecae1a317a315623e14
https://doi.org/10.1158/1535-7163.c.6538488.v1
https://doi.org/10.1158/1535-7163.c.6538488.v1
Autor:
Deborah A. Lannigan, George A. O'Doherty, Jennifer A. Pietenpol, David R. Brenin, Miranda E. Sowder, Lejla Pasic, Zachary M. Sandusky, Yu Li, Mingzong Li, J. Preston Campbell, Katarzyna A. Ludwik
Scratch assay using HDQ-P1 cells. Top vehicle, bottom (1b) (50 μM) over a 10h time frame.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe2f4a87b8e3cb08826060d505d988c
https://doi.org/10.1158/1535-7163.22506756.v1
https://doi.org/10.1158/1535-7163.22506756.v1
Autor:
Deborah A. Lannigan, George A. O'Doherty, Jennifer A. Pietenpol, David R. Brenin, Miranda E. Sowder, Lejla Pasic, Zachary M. Sandusky, Yu Li, Mingzong Li, J. Preston Campbell, Katarzyna A. Ludwik
Supplementary Materials and Methods; Table S1 and Figures S1 through S5; Supplementary Movies S1 through S3 Legends - Supplementary Materials and Methods: Description of velocity determination, conditions for immunostaining and sources and applicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5c0ea993aa1da9ce24a7474708a263
https://doi.org/10.1158/1535-7163.22506765
https://doi.org/10.1158/1535-7163.22506765
Publikováno v:
Hematology/oncology clinics of North America. 37(1)
The estrogen receptor is a key driver of estrogen receptor-positive breast cancers. Accumulating evidence indicates that the ESR1 ligand-binding domain mutations have an important role in acquired endocrine resistance, mainly to treatment with aromat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7778264229494cd270c0b5f67e43c51e
https://pubmed.ncbi.nlm.nih.gov/36435608
https://pubmed.ncbi.nlm.nih.gov/36435608
Autor:
Yu Li, Rajender Vemula, Qi Zhang, Shinji Fukuda, George A. O'Doherty, Bulan Wu, Zachary M. Sandusky, Deborah A. Lannigan, Mingzong Li
Publikováno v:
Organic Letters. 22:1448-1452
An asymmetric synthesis of two analogues of SL0101 (1) has been achieved. The effort is aimed at the discovery of inhibitors of the p90 ribosomal S6 kinase (RSK) with improved bioavailability. The route relies upon the use of the Taylor catalyst to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b998bf25c939ed6e1b127a9f5c5965
https://doi.org/10.1021/acs.orglett.0c00042
https://doi.org/10.1021/acs.orglett.0c00042
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1878:188830
Estrogen receptor-positive breast cancer is the most common type of both early and advanced breast cancer. Estrogen receptor alpha (ER) is a nuclear hormone receptor and a key driver of tumorigenesis and tumor progression in these breast cancers. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c06ad9386ccda362d5fd23b39b9664a
https://doi.org/10.1016/j.bbcan.2022.188830
https://doi.org/10.1016/j.bbcan.2022.188830
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100270-(2021)
STAR Protocols
STAR Protocols
Summary A FACS protocol is described that eliminates isolation and staining artifacts to allow accurate comparison between cell populations isolated from organs obtained from disparate mouse groups. This protocol was validated by characterizing the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d67d3e8c23cdb1f0a591c64d69bec710
http://www.sciencedirect.com/science/article/pii/S2666166720302574
http://www.sciencedirect.com/science/article/pii/S2666166720302574
Autor:
Zachary M. Sandusky
Publikováno v:
Journal of the Endocrine Society
In response to estrogens, estrogen receptor alpha (ERα) is degraded by the 26S proteasome; however, despite the continued presence of estrogen prior to menopause, ERα protein levels are maintained by an unidentified mechanism. We find that the Ser/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047cebf9b7b607bf9b17dd64a028bf1d
http://europepmc.org/articles/PMC6554916
http://europepmc.org/articles/PMC6554916
Autor:
Zachary M. Sandusky, Jennifer A. Pietenpol, Deborah A. Lannigan, J. Preston Campbell, David R. Brenin, Katarzyna A. Ludwik, Mingzong Li, Yu Li, George A. O'Doherty, Lejla Pasic, Miranda E. Sowder
Publikováno v:
Molecular Cancer Therapeutics. 15:2598-2608
Metastatic breast cancer is an incurable disease and identification of novel therapeutic opportunities is vital. Triple-negative breast cancer (TNBC) frequently metastasizes and high levels of activated p90RSK (RSK), a downstream MEK-ERK1/2 effector,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921d38fb3605faaddbd2f2e3650c6df8
https://doi.org/10.1158/1535-7163.mct-16-0106
https://doi.org/10.1158/1535-7163.mct-16-0106