Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zachary M. Kiser"'
Autor:
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD
Externí odkaz:
https://doaj.org/article/8b85be8fe59f4192a1fe566fbb2c75ec
Autor:
John D. Belcher, Ping Zhang, Julia Nguyen, Zachary M. Kiser, Karl A. Nath, Jianjun Hu, John O. Trent, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Myeloid differentiation factor-2 (MD-2) binds lipopolysaccharide (LPS) and initiates toll-like receptor-4 (TLR4) pro-inflammatory signaling. Heme also activates TLR4 signaling, but it is unknown if heme interacts with MD-2. Therefore, we examined MD-
Externí odkaz:
https://doaj.org/article/99eb18fc3b6b43cfa494c8c1667c1c26
Autor:
Zachary M. Kiser, Monica D.M. McGee, Racquel J. Wright, Alexander Quarshie, Gale W. Newman, Karen R. Randall, Jonathan K. Stiles, Adel Driss, Jacqueline M. Hibbert
Publikováno v:
PeerJ, Vol 5, p e3376 (2017)
Background Chronic inflammation is a characteristic of sickle cell disease (SCD), and is invariably associated with vascular endothelial injury. Hydroxyurea (HU), a naturally cytotoxic chemotherapeutic agent, is the only FDA drug approved for SCD, an
Externí odkaz:
https://doaj.org/article/cc46985c91054aef9ff8c02f97e30b04
Autor:
M. Ayumi Deeny, Justin A. McClain, Dayna M. Hayes, Kimberly Nixon, Zachary M. Kiser, Stephanie A. Morris, S. Alex Marshall
Publikováno v:
Brain, Behavior, and Immunity. 25:S120-S128
Accumulating evidence indicates that the adolescent hippocampus is highly susceptible to alcohol-induced structural damage and behavioral deficits. Microglia are vitally important brain constituents needed to support and maintain proper neural functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569e3226028b71ded46c34daf0cbe12b
https://doi.org/10.1016/j.bbi.2011.01.006
https://doi.org/10.1016/j.bbi.2011.01.006
Autor:
John D Belcher, Edward Gomperts, Julia Nguyen, Chunsheng Chen, Fuad Abdulla, Zachary M Kiser, David Gallo, Howard Levy, Leo E Otterbein, Gregory M Vercellotti
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205194 (2018)
Carbon monoxide (CO) at low, non-toxic concentrations has been previously demonstrated to exert anti-inflammatory protection in murine models of sickle cell disease (SCD). However CO delivery by inhalation, CO-hemoglobin infusion or CO-releasing mole
Externí odkaz:
https://doaj.org/article/1af0ae6a320f4a209a40e827dfb618ef