Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Zachary M Sticher"'
Autor:
Carolin M Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K Johnson, Cheryl A Jones, Zachary M Sticher, Alexander A Kolykhalov, Manohar T Saindane, Stephen M Tompkins, Oliver Planz, George R Painter, Michael G Natchus, Kaori Sakamoto, Richard K Plemper
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011342 (2023)
Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential
Externí odkaz:
https://doaj.org/article/6936c60659ba4a96b921b668517dfbee
Autor:
Robert M. Cox, Josef D. Wolf, Nicole A. Lieberman, Carolin M. Lieber, Hae-Ji Kang, Zachary M. Sticher, Jeong-Joong Yoon, Meghan K. Andrews, Mugunthan Govindarajan, Rebecca E. Krueger, Elizabeth B. Sobolik, Michael G. Natchus, Andrew T. Gewirtz, Rik L. deSwart, Alexander A. Kolykhalov, Khan Hekmatyar, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Measles cases have surged pre-COVID-19 and the pandemic has aggravated the problem. Most measles-associated morbidity and mortality arises from destruction of pre-existing immune memory by measles virus (MeV), a paramyxovirus of the morbilli
Externí odkaz:
https://doaj.org/article/c318e8440b28489e92886789df7a2812
Autor:
Kevin Wittwer, Danielle E. Anderson, Kristin Pfeffermann, Robert M. Cox, Josef D. Wolf, Sabine Santibanez, Annette Mankertz, Roland Plesker, Zachary M. Sticher, Alexander A. Kolkykhalov, Michael G. Natchus, Christian K. Pfaller, Richard K. Plemper, Veronika von Messling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Measles virus is highly contagious and outbreaks occur worldwide. Here the authors show that the orally bioavailable small-molecule polymerase inhibitor ERDRP-0519 prevents measles disease in squirrel monkeys and reduces virus shedding.
Externí odkaz:
https://doaj.org/article/5330f59bd9fe43ada6a0147032c636eb
Autor:
Robert M Cox, Carolin M Lieber, Josef D Wolf, Amirhossein Karimi, Nicole A P Lieberman, Zachary M Sticher, Pavitra Roychoudhury, Meghan K Andrews, Rebecca E Krueger, Michael G Natchus, George R Painter, Alexander A Kolykhalov, Alexander L Greninger, Richard K Plemper
Publikováno v:
bioRxiv
Despite the continued spread of SARS-CoV-2 and emergence of variants of concern (VOC) that are capable of escaping preexisting immunity, therapeutic options are underutilized. In addition to preventing severe disease in high-risk patients, antivirals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d826bcf5816628c7ba9b71dc6797bf6
https://pubmed.ncbi.nlm.nih.gov/36451893
https://pubmed.ncbi.nlm.nih.gov/36451893
Autor:
Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Mart Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar T. Saindane, Stephen M. Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper
Influenza outbreaks are associated with substantial morbidity, mortality and economic burden. Next generation antivirals are needed to treat seasonal infections and prepare against zoonotic spillover of avian influenza viruses with pandemic potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06b4a0e6406c62c40e4bba51689586e8
https://doi.org/10.1101/2022.11.05.515296
https://doi.org/10.1101/2022.11.05.515296
Autor:
Carolin M. Lieber, Robert M. Cox, Julien Sourimant, Josef D. Wolf, Kate Juergens, Quynh Phung, Manohar T. Saindane, Meghan K. Smith, Zachary M. Sticher, Alexander A. Kalykhalov, Michael G. Natchus, George R. Painter, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper
Publikováno v:
bioRxiv
SARS-CoV-2 variants of concern (VOC) have triggered distinct infection waves in the coronavirus disease 2019 (COVID-19) pandemic, culminating in currently all-time high incidence rates of VOC omicron. Orally available direct-acting antivirals such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7581141689e41f8825d22e9dfed99e98
https://doi.org/10.1038/s41467-022-32045-1
https://doi.org/10.1038/s41467-022-32045-1
Autor:
Benhur Lee, Robert M. Cox, Jose R. Marengo, Negar Makhsous, Mart Toots, Jeong-Joong Yoon, Richard K. Plemper, Mugunthan Govindarajan, Satoshi Ikegame, Alexander L. Greninger, Michael G. Natchus, Ruth E. Watkinson, Michelle J. Lin, Julien Sourimant, Zachary M. Sticher, Alexander A. Kolykhalov, Patricia A. Thibault
Publikováno v:
Nature microbiology
Paramyxoviruses such as human parainfluenza virus type-3 (HPIV3) and measles virus (MeV) are a substantial health threat. In a high-throughput screen for inhibitors of HPIV3 (a major cause of acute respiratory infection), we identified GHP-88309—a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52729f7232a684354bf11b7c3674a89
https://doi.org/10.1038/s41564-020-0752-7
https://doi.org/10.1038/s41564-020-0752-7
Autor:
Julien Sourimant, Mart Toots, Carolin M. Lieber, Zachary M. Sticher, Richard K. Plemper, Michael G. Natchus, Alexander A. Kolykhalov, Megha Aggarwal, Robert M. Cox, Luis Martinez-Sobrido, Jeong-Joong Yoon, George R. Painter, Chengjin Ye, Gregory R. Bluemling, Josef D. Wolf
The COVID-19 pandemic has underscored the critical need for broad-spectrum therapeutics against respiratory viruses. Respiratory syncytial virus (RSV) is a major threat to pediatric patients and the elderly. We describe 4’-fluorouridine (4’-FlU,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6df8af719de894a0c1101eb8de1a4b
https://doi.org/10.1101/2021.05.19.444875
https://doi.org/10.1101/2021.05.19.444875
Autor:
Manohar Saindane, Debbie G. Mitchell, Prabhakar Reddy, Abel De La Rosa, Gregory R. Bluemling, Alexander A. Kolykhalov, Vindhya Edpuganti, Douglas L. Mayers, Katherine E. Squires, Zachary M. Sticher, David B. Guthrie
Publikováno v:
Antimicrobial Agents and Chemotherapy
ATI-2173 is a novel liver-targeted molecule designed to deliver the 5′-monophosphate of clevudine for the treatment of chronic hepatitis B infection. Unlike other nucleos(t)ides, the active clevudine-5′-triphosphate is a noncompetitive, non-chain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1b3d002d80deb59b3cf88491e49ca3
https://pubmed.ncbi.nlm.nih.gov/32540975
https://pubmed.ncbi.nlm.nih.gov/32540975
Autor:
Deborah G. Mitchell, Zachary M. Sticher, Joshua Marlow, Michael G. Natchus, Gregory R. Bluemling, Gaofei Lu, Levi Moellering, Alexander A. Kolykhalov, David B. Guthrie, George R. Painter
Publikováno v:
Antimicrobial Agents and Chemotherapy
N 4-Hydroxycytidine (NHC) is an antiviral ribonucleoside analog that acts as a competitive alternative substrate for virally encoded RNA-dependent RNA polymerases. It exhibits measurable levels of cytotoxicity, with 50% cytotoxic concentration values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368af32de667f36851dbfe5dcb128b6