Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zachary M Huttinger"'
Autor:
Zachary M. Huttinger, Laura M. Haynes, Andrew Yee, Colin A. Kretz, Matthew L. Holding, David R. Siemieniak, Daniel A. Lawrence, David Ginsburg
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Mis
Externí odkaz:
https://doaj.org/article/f47950a71a2243e4bed673bbf54e9f40
Autor:
Laura M. Haynes, Zachary M. Huttinger, Andrew Yee, Colin A. Kretz, David R. Siemieniak, Daniel A. Lawrence, David Ginsburg
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (SERPIN) superfamily of proteins, is unique among SERPINs for exhibiting a spontaneous conformational change to a latent or inactive state. The functional half-life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da8a4cae23d0fa26f3c436ba8ad59de
https://doi.org/10.1101/2022.07.19.500671
https://doi.org/10.1101/2022.07.19.500671
Autor:
Chandler J. Rygalski, Zachary M. Huttinger, Songzhu Zhao, Guy Brock, Kyle VanKoevering, Matthew O. Old, Theodoros N. Teknos, James W. Rocco, Sidharth V. Puram, Nolan B. Seim, Brian Swendseid, Catherine T. Haring, Antoine Eskander, Stephen Y. Kang
Publikováno v:
Oral Oncology. 138:106333
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14c5b60cf539e666c4f2cc8fbfe6512
https://doi.org/10.1016/j.oraloncology.2023.106333
https://doi.org/10.1016/j.oraloncology.2023.106333
Autor:
Laura M. Haynes, Zachary M. Huttinger, Andrew Yee, Colin A. Kretz, David R. Siemieniak, Daniel A. Lawrence, David Ginsburg
Publikováno v:
Journal of Biological Chemistry. 298:102608
Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor superfamily of proteins, is unique among serine protease inhibitors for exhibiting a spontaneous conformational change to a latent or inactive state. The functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ee7a6a92edfd5eefb592633a147fc24
https://doi.org/10.1016/j.jbc.2022.102608
https://doi.org/10.1016/j.jbc.2022.102608
Autor:
David R. Siemieniak, Andrew Yee, Laura M. Haynes, Daniel A. Lawrence, David Ginsburg, Matthew L Holding, Zachary M Huttinger, Colin A. Kretz
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a9da89b60b96afdc166b8a55ca1130
https://doi.org/10.1038/s41598-021-97871-7
https://doi.org/10.1038/s41598-021-97871-7
Autor:
Harry L. T. Mobley, Zachary M Huttinger, Sara N. Smith, Ursula Waack, David Ginsburg, Ayush Kumar, Daniel A. Lawrence, Andrew Yee, Alban Deroux, Mark Warnock, Maria Sandkvist
Publikováno v:
mBio
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01606-18 (2018)
mBio, Vol 9, Iss 6 (2018)
mBio, Vol 9, Iss 6, p e01606-18 (2018)
Ventilator-associated pneumonia and catheter-related bacteremia are the most common and severe infections caused by Acinetobacter baumannii. Besides the capsule, lipopolysaccharides, and the outer membrane porin OmpA, little is known about the contri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12d68331dd94118e9f3692c90a6eec5
https://doi.org/10.1128/mbio.01606-18
https://doi.org/10.1128/mbio.01606-18
Autor:
Ryan M. Huttinger, Simon C. Robson, Adam Reynolds, Debra G Wheeler, Richard J. Gumina, Katherine Stanfill, Tatiana Novitskaya, Elena Chepurko, Karen M. Dwyer, Roman Covarrubias, Peter J. Cowan, Zachary M. Huttinger
Objective— Circulating blood cells and endothelial cells express ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5′-nucleotidase (CD73). CD39 hydrolyzes extracellular ATP or ADP to AMP. CD73 hydrolyzes AMP to adenosine. The goal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c0e589d3aee316ad2c1f0dabef0487
https://europepmc.org/articles/PMC5206760/
https://europepmc.org/articles/PMC5206760/
Autor:
Lawrence J. Druhan, Zachary M. Huttinger, Peter J. Cowan, Lauren A. Goodman, Guanglong He, Debra G Wheeler, Anthony J. F. D'apice, Heng He, Feng Li, Weizhi Zhang, Ming Cai, Jay L. Zweier, Simon C. Robson, Richard J. Gumina, Karen M. Dwyer
Publikováno v:
Journal of Molecular and Cellular Cardiology. 51:927-935
Modulation of purinergic signaling is critical to myocardial homeostasis. Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) which converts the proinflammatory molecules ATP or ADP to AMP is a key regulator of purinergic modulation. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25102e3f1b4b577f7776e86e0c1d263
https://doi.org/10.1016/j.yjmcc.2011.09.003
https://doi.org/10.1016/j.yjmcc.2011.09.003
Autor:
Adam Reynolds, Zachary M Huttinger, William L Aurand, Ryan M Huttinger, Katerine Stanfill, Debra G Wheeler, Tatiana Novitskaya, Simon C Robson, Karen M Dwyer, Peter J Dwyer, Richard J Gumina
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Objective: To determine the effect of increased CD39 expression on circulating blood components on in vivo arterial thrombosis in mice. Approach and Results: We have previously demonstrated that increased global expression of hCD39 conveys an anti-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e725e767a67ce5b6d7805a414a47ff5
https://doi.org/10.1161/atvb.34.suppl_1.19
https://doi.org/10.1161/atvb.34.suppl_1.19
Autor:
Debra G Wheeler, Lawrence C. Long, Michael S Nickoli, Anthony J F D'Apice, Zachary M. Huttinger, Peter J. Cowan, William L. Aurand, Simon C. Robson, Richard J. Gumina, Karen M. Dwyer, Michael W Milks
Publikováno v:
The American journal of pathology. 181(1)
Modulation of purinergic signaling, which is critical for vascular homeostasis and the response to vascular injury, is regulated by hydrolysis of proinflammatory ATP and/or ADP by ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD-1; CD39) to AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f737e92044edee1b8ce153953320be7b
https://pubmed.ncbi.nlm.nih.gov/22613024
https://pubmed.ncbi.nlm.nih.gov/22613024