Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary M Hostetler"'
Autor:
Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Matthew J. Culyba, Zachary M. Hostetler, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response
Externí odkaz:
https://doaj.org/article/fc69e9d5be4840acbcfd56e5aaba5e04
Autor:
Michael B. Cory, Allen Li, Christina M. Hurley, Zachary M. Hostetler, Yarra Venkatesh, Chloe M. Jones, E. James Petersson, Rahul M. Kohli
The SOS response is a bacterial DNA damage response pathway that has been heavily implicated in bacteria’s ability to evolve resistance to antibiotics. Activation of the SOS response is dependent on the interaction between two bacterial proteins, R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812a4304f01c14cb4667cf4ade1275e8
https://doi.org/10.1101/2022.09.30.510415
https://doi.org/10.1101/2022.09.30.510415
Publikováno v:
Methods in enzymology. 664
The formation of macromolecular complexes containing multiple protein binding partners is at the core of many biochemical pathways. Studying the kinetics of complex formation can offer significant biological insights and complement static structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df410b85af85ab5a32d7f3dd1949b520
https://pubmed.ncbi.nlm.nih.gov/35331372
https://pubmed.ncbi.nlm.nih.gov/35331372
Publikováno v:
Methods in Enzymology ISBN: 9780323912228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a65231d125e9ff12800b88b4d9384f57
https://doi.org/10.1016/bs.mie.2022.01.009
https://doi.org/10.1016/bs.mie.2022.01.009
Publikováno v:
ACS Chem Biol
The bacterial DNA damage response (the SOS response) is a key pathway involved in antibiotic evasion and a promising target for combating acquired antibiotic resistance. Activation of the SOS response is controlled by two proteins: the repressor LexA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb664b0c25969f9211adb56a1928131
https://europepmc.org/articles/PMC7230020/
https://europepmc.org/articles/PMC7230020/
Autor:
Jessica L. Schneck, Charlie Y. Mo, Zachary M Hostetler, Anthony J. Jurewicz, Paul M. Keller, Trevor Selwood, Amy Quinn, Andrew J. Pope, Matthew J. Culyba, Widdowson Katherine L, Rahul M. Kohli, Jeffrey M. Kubiak
Publikováno v:
ACS Infectious Diseases. 4:349-359
The RecA/LexA axis of the bacterial DNA damage (SOS) response is a promising, yet non-traditional drug target. The SOS response is initiated upon genotoxic stress, when RecA, a DNA damage sensor, induces LexA, the SOS repressor, to undergo autoproteo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a7888f32c398e2cbcc453832db48f9
https://doi.org/10.1021/acsinfecdis.7b00122
https://doi.org/10.1021/acsinfecdis.7b00122
Autor:
Lee C. Speight, Zachary M Hostetler, Camden M. Driggers, Jeffery G. Saven, Lea Z. Mbengi, Rahul M. Kohli, José A. Villegas, John J. Perona, Robert J. Blizzard, Itthipol Sungwienwong, E. James Petersson, Ryan A. Mehl, Joseph J. Porter
Publikováno v:
Organic & Biomolecular Chemistry. 15:3603-3610
The amino acid acridon-2-ylalanine (Acd) can be a valuable probe of protein dynamics, either alone or as part of a Förster resonance energy transfer (FRET) or photo-induced electron transfer (eT) probe pair. We have previously reported the genetic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa81492101a864299bb76a8b05dfbaef
https://doi.org/10.1039/c7ob00582b
https://doi.org/10.1039/c7ob00582b
Autor:
Marc R. Bornstein, John J. Ferrie, Zachary M Hostetler, Itthipol Sungwienwong, E. James Petersson, Rahul M. Kohli
Publikováno v:
ACS chemical biology. 13(10)
Improvements in genetic code expansion have made preparing proteins with diverse functional groups almost routine. Nonetheless, unnatural amino acids (Uaas) pose theoretical burdens on protein solubility, and determinants of position-specific tolerab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d49ce3c8567633026a6a95fdf1b6ac2
https://pubmed.ncbi.nlm.nih.gov/30216041
https://pubmed.ncbi.nlm.nih.gov/30216041
Autor:
Rahul M. Kohli, George A. Petersson, Anand K. Muthusamy, Naoya Ieda, Taylor M. Barrett, Zachary M Hostetler, Joomyung V. Jun, Chunxiao Liu, E. James Petersson, Itthipol Sungwienwong, Amara Hendricks, John J. Ferrie, David M. Chenoweth
Publikováno v:
Journal of Physical Organic Chemistry. 31
Acridonylalanine (Acd) is a useful fluorophore for studying proteins by fluorescence spectroscopy, but it can potentially be improved by being made longer wavelength or brighter. Here, we report the synthesis of Acd core derivatives and their photoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28bdea2466ebb0d7c22c26576a6f839
https://doi.org/10.1002/poc.3813
https://doi.org/10.1002/poc.3813
Publikováno v:
Nature structuralmolecular biology. 24(2)
Targeted deamination of cytosine bases in DNA by AID/APOBEC-family enzymes is critical for proper immune function, but it also poses risks to genomic integrity. New structures reported by Harris, Aihara and colleagues offer the first glimpses into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7219bdf02093cbb42e178ce988b9a1
https://pubmed.ncbi.nlm.nih.gov/28169999
https://pubmed.ncbi.nlm.nih.gov/28169999