Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Zachary L Watson"'
Autor:
Lindsay J. Wheeler, Zachary L. Watson, Lubna Qamar, Tomomi M. Yamamoto, Brandon T. Sawyer, Kelly D. Sullivan, Santosh Khanal, Molishree Joshi, Veronique Ferchaud-Roucher, Harry Smith, Lauren A. Vanderlinden, Sky W. Brubaker, Cecilia M. Caino, Hyunmin Kim, Joaquin M. Espinosa, Jennifer K. Richer, Benjamin G. Bitler
Publikováno v:
iScience, Vol 19, Iss , Pp 474-491 (2019)
Summary: High-grade serous ovarian cancers (HGSOCs) arise from exfoliation of transformed cells from the fallopian tube, indicating that survival in suspension, and potentially escape from anoikis, is required for dissemination. We report here the re
Externí odkaz:
https://doaj.org/article/d7cae58c70cf4b989ef74c7cfa5a6c7f
Autor:
Lindsay W. Brubaker, Donald S. Backos, Vu T. Nguyen, Philip Reigan, Tomomi M Yamamoto, Elizabeth R. Woodruff, Ritsuko Iwanaga, Michael F. Wempe, Vijay Kumar, Christianne Persenaire, Zachary L. Watson, Benjamin G. Bitler
Publikováno v:
Expert Opinion on Therapeutic Targets. :1-11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05bb72902b5fcb68b31e7422a9211081
https://doi.org/10.1080/14728222.2023.2218614
https://doi.org/10.1080/14728222.2023.2218614
Autor:
Bradley R Corr, Marisa R Moroney, Elizabeth Woodruff, Zachary L Watson, Kimberly R. Jordan, Thomas Danhorn, Courtney Bailey, Rebecca J Wolsky, Benjamin G Bitler
SM08502 (cirtuvivint) is a novel pan CDC-like kinase (CLK) and Dual specificity tyrosine kinase (DYRK) inhibitor that targets mRNA splicing and is optimized for Wnt pathway inhibition. Previous evaluation of single agent CLK/DYRK inhibition (SM04690)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::247389efc0ce3622899c391d1a8f4d36
https://doi.org/10.1101/2023.04.04.535570
https://doi.org/10.1101/2023.04.04.535570
Autor:
Benjamin G. Bitler, Neil Johnson, Paul S. Mischel, Elizabeth M. Swisher, Silvia Casadei, Kian Behbakht, Zachary L. Watson, Andrew V. Kossenkov, Kristen M. Turner, Andrea J. Bernhardy, Yifan Wang, Bing Xia, Allen L. Alcivar, Hua Li, Tomomi M. Yamamoto, Pyoung Hwa Park
Immunoprecipitation of BRCA2 . List of proteins identified via mass spectrometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c3719a3603c8d1f9fbeb54a1d1fd00
https://doi.org/10.1158/1535-7163.22506633.v1
https://doi.org/10.1158/1535-7163.22506633.v1
Autor:
Benjamin G. Bitler, Neil Johnson, Paul S. Mischel, Elizabeth M. Swisher, Silvia Casadei, Kian Behbakht, Zachary L. Watson, Andrew V. Kossenkov, Kristen M. Turner, Andrea J. Bernhardy, Yifan Wang, Bing Xia, Allen L. Alcivar, Hua Li, Tomomi M. Yamamoto, Pyoung Hwa Park
Patients harboring germline breast cancer susceptibility genes 1 and 2 (BRCA1/2) mutations are predisposed to developing breast, pancreatic, and ovarian cancers. BRCA2 plays a critical role in homologous recombination (HR) DNA repair and deleterious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e778c74a3f8f3abad668636d1d3a106
https://doi.org/10.1158/1535-7163.c.6538452.v1
https://doi.org/10.1158/1535-7163.c.6538452.v1
Autor:
Benjamin G. Bitler, Isabel R. Schlaepfer, Kian Behbakht, Jennifer K. Richer, Zachary L. Watson, Alexandra McMellen, Tomomi M. Yamamoto, Lubna Qamar, Brandon T. Sawyer
Figure S1. HGSOC cells cultured in suspension upregulate Carnitine and Fatty Acid Metabolism. Figure S2. Confirmation of CPT1A antibody specificity. Figure S3. Oxygen consumption rate (OCR) in suspension cells and oleic acid rescue of anoikis. Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bb67eb67bccae46751d5398b5ce697
https://doi.org/10.1158/1541-7786.22517206.v1
https://doi.org/10.1158/1541-7786.22517206.v1
Autor:
Benjamin G. Bitler, T. Rajendra Kumar, Kian Behbakht, Aaron Clauset, James C. Costello, Tomomi M. Yamamoto, Zachary L. Watson, Rebecca J. Wolsky, Junxiao Hu, Marisa R. Moroney, Jennifer K. Richer, Angela Minic, Jill E. Slansky, Matthew J. Sikora, Kimberly R. Jordan
Detailed Clinical History. Supplemental figure legend Supplemental table legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28950ffc95d99ad0c9f1ed4977899d79
https://doi.org/10.1158/1078-0432.22477890.v1
https://doi.org/10.1158/1078-0432.22477890.v1
Autor:
Benjamin G. Bitler, T. Rajendra Kumar, Kian Behbakht, Aaron Clauset, James C. Costello, Tomomi M. Yamamoto, Zachary L. Watson, Rebecca J. Wolsky, Junxiao Hu, Marisa R. Moroney, Jennifer K. Richer, Angela Minic, Jill E. Slansky, Matthew J. Sikora, Kimberly R. Jordan
Top 18 genes that correlated with IL6 expression in Nanostring dataset (n=12) and TCGA dataset (n=489).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1890d12a10743d9b4495800404ec6341
https://doi.org/10.1158/1078-0432.22477878.v1
https://doi.org/10.1158/1078-0432.22477878.v1
Autor:
Benjamin G. Bitler, T. Rajendra Kumar, Kian Behbakht, Aaron Clauset, James C. Costello, Tomomi M. Yamamoto, Zachary L. Watson, Rebecca J. Wolsky, Junxiao Hu, Marisa R. Moroney, Jennifer K. Richer, Angela Minic, Jill E. Slansky, Matthew J. Sikora, Kimberly R. Jordan
Purpose:Ovarian cancer has one of the highest deaths to incidence ratios across all cancers. Initial chemotherapy is effective, but most patients develop chemoresistant disease. Mechanisms driving clinical chemo-response or -resistance are not well-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cc561c180e1cbf750dc008e8f372add
https://doi.org/10.1158/1078-0432.c.6529782.v1
https://doi.org/10.1158/1078-0432.c.6529782.v1
Autor:
Lily L. Nguyen, Zachary L. Watson, Raquel Ortega, Elizabeth R. Woodruff, Kimberly R. Jordan, Ritsuko Iwanaga, Tomomi M. Yamamoto, Courtney A. Bailey, Abigail D. Jeong, Saketh R. Guntupalli, Kian Behbakht, Veronica Gbaja, Nausica Arnoult, Edward B. Chuong, Benjamin G. Bitler
Publikováno v:
bioRxiv
Euchromatic histone lysine methyltransferases 1 and 2 (EHMT1/2), which catalyze demethylation of histone H3 lysine 9 (H3K9me2), contribute to tumorigenesis and therapy resistance through unknown mechanisms of action. In ovarian cancer, EHMT1/2 and H3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8029f367c1b37e79d7769f85eee654
https://doi.org/10.1101/2023.02.23.529773
https://doi.org/10.1101/2023.02.23.529773