Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Zachary Kratche"'
Publikováno v:
Experimental Cell Research. 332:223-235
Gene amplification is a common mechanism of oncogene activation in cancer. Several large-scale efforts aimed at identifying the comprehensive set of genomic regions that are recurrently amplified in cancer have been completed. In breast cancer, these
Autor:
Stephen P. Ethier, Zachary Kratche, Ramsi Haddad, Jonathan C. Irish, Elizabeth Garrett-Mayer, Joe W. Gray, Robert C. Wilson, Stephen T. Guest
Publikováno v:
Oncotarget
// Stephen T. Guest 1 , Zachary R. Kratche 1 , Jonathan C. Irish 1 , Robert C. Wilson 1 , Ramsi Haddad 1 , Joe W. Gray 3, 4 , Elizabeth Garrett-Mayer 2 , Stephen P. Ethier 1 1 Department of Pathology and Laboratory Medicine, Hollings Cancer Center, M
Publikováno v:
Cancer Research. 77:2314-2314
Bcl-2 homology domain 3 (BH3) mimetics are a new class of targeted anti-cancer compounds that function by inducing cancer cell apoptosis. Testing in a variety of pre-clinical tumor models has shown that BH3 mimetics are capable of inducing remarkable
Autor:
Stephen Guest, Stephen P. Ethier, Zachary Kratche, Christiana S. Kappler, Jonathan C. Irish, Elizabeth Garrett-Mayer, Ericka L. Smith
Publikováno v:
Cancer Research. 75:1949-1949
A subset of triple negative breast cancer (TNBC) is characterized by overexpression of the epidermal growth factor receptor (EGFR) and loss of PTEN, and patients with these factors have a poor prognosis. In addition, approximately half of all basal b
Autor:
Jonathan M. Irish, Stephen P. Ethier, Aliccia Bollig-Fischer, Zachary Kratche, Stephen Guest, Elizabeth Garrett-Mayer
Publikováno v:
Cancer Research. 75:1116-1116
During the course of tumorigenesis, cancer cells acquire a large number of genetic and epigenetic alterations. A subset of these alterations results in the generation of driver oncogenes that play critical roles in initiating and maintaining the tran
Autor:
Jon Irish, Elizabeth Garrett-Mayer, Stephen T. Guest, Stephen P. Ethier, Robert B Wilson, Zachary Kratche
Publikováno v:
Cancer Research. 74:440-440
Large-scale efforts such as The Cancer Genome Atlas (TCGA) have identified the landscape of genetic, epigenetic and proteomic alterations in breast cancer through analysis of ∼1000 primary breast tumors. Importantly, all of the samples analyzed by