Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Zachary Klase"'
Autor:
Angel Lin, Weam Othman Elbezanti, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin, Zachary Klase
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
The HIV-1 pandemic is a significant challenge to the field of medicine. Despite advancements in antiretroviral (ART) development, 38 million people worldwide still live with this disease without a cure. A significant barrier to the eradication of HIV
Externí odkaz:
https://doaj.org/article/407f56e130394e5f93ffbeac3e52c868
Autor:
Kenneth Chen, Thienlong Phan, Angel Lin, Luca Sardo, Anthony R Mele, Michael R Nonnemacher, Zachary Klase
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0230563 (2020)
Despite antiretroviral therapy human immunodeficiency virus type-1 (HIV-1) infection results in neuroinflammation of the central nervous system that can cause HIV-associated neurocognitive disorders (HAND). The molecular mechanisms involved in the de
Externí odkaz:
https://doaj.org/article/ab94f14817b34edc8db989ab72fd19aa
Autor:
Norman Fultang, Abhinav Illendula, Brian Chen, Chun Wu, Subash Jonnalagadda, Nathan Baird, Zachary Klase, Bela Peethambaran
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217789 (2019)
Triple Negative Breast Cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by the absence of hormone receptors usually targeted by hormone therapies like Tamoxifen. Because therapy success and survival rates for TNBC lag far
Externí odkaz:
https://doaj.org/article/74840e4721fa4152a067de9273003ae4
Autor:
Weam Elbezanti, Angel Lin, Alexis Schirling, Alexandria Jackson, Matthew Marshall, Rachel Van Duyne, Frank Maldarelli, Luca Sardo, Zachary Klase
Publikováno v:
Viruses, Vol 12, Iss 2, p 191 (2020)
Antiretroviral therapy (ART) lowers human immunodeficiency virus type 1 (HIV-1) viral load to undetectable levels, but does not eliminate the latent reservoir. One of the factors controlling the latent reservoir is transcriptional silencing of the in
Externí odkaz:
https://doaj.org/article/4c9ea35137d24e1e9f48884d828e0155
Autor:
Fatah Kashanchi, Kylene Kehn-Hall, Aarthi Narayanan, Zachary Klase, Elizabeth Jaworski, Ravi Das, Irene Guendel, Gavin C. Sampey
Publikováno v:
Biology, Vol 1, Iss 2, Pp 339-369 (2012)
Gene silencing via non-coding RNA, such as siRNA and miRNA, can occur at the transcriptional, post-transcriptional, and translational stages of expression. Transcriptional gene silencing (TGS) involving the RNAi machinery generally occurs through DNA
Externí odkaz:
https://doaj.org/article/677a8eec7a73409b97f72557637df71e
Autor:
Zachary Klase, Venkat S R K Yedavalli, Laurent Houzet, Molly Perkins, Frank Maldarelli, Jason Brenchley, Klaus Strebel, Paul Liu, Kuan-Teh Jeang
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003997 (2014)
A major barrier to the elimination of HIV-1 infection is the presence of a pool of long-lived, latently infected CD4+ memory T-cells. The search for treatments to re-activate latent HIV to aid in clearance is hindered by the incomplete understanding
Externí odkaz:
https://doaj.org/article/d632cbc1bf5741dabf5e95d610150b08
Autor:
Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40662 (2012)
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that the cellular RNAi machinery is a major means by which the host mounts a defense response against present day retroviruses.
Externí odkaz:
https://doaj.org/article/8881e5cfb3a6451789826816022e8d18
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8523be2f6afcf2241287bc578108fd22
https://doi.org/10.1096/fasebj.2022.36.s1.r3415
https://doi.org/10.1096/fasebj.2022.36.s1.r3415
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2175
Modifications in chromatin structure are traditionally monitored by biochemical assays that provide average measurements of static events in a population of cells. Microscopy provides a method by which single cells or nuclei can be observed. Traditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45fdc5eaaebd206c6475f1be252d7435
https://pubmed.ncbi.nlm.nih.gov/32681481
https://pubmed.ncbi.nlm.nih.gov/32681481
Publikováno v:
The Nucleus ISBN: 9781071607626
Modifications in chromatin structure are traditionally monitored by biochemical assays that provide average measurements of static events in a population of cells. Microscopy provides a method by which single cells or nuclei can be observed. Traditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e29a870e87cfab11cdba6e8cf1eca28
https://doi.org/10.1007/978-1-0716-0763-3_3
https://doi.org/10.1007/978-1-0716-0763-3_3
