Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Zachary K Norgaard"'
Autor:
Christopher W. Peterson, Jennifer E. Adair, Martin E. Wohlfahrt, Claire Deleage, Stefan Radtke, Blake Rust, Krystin K. Norman, Zachary K. Norgaard, Lauren E. Schefter, Gabriella M. Sghia-Hughes, Andrea Repetto, Audrey Baldessari, Robert D. Murnane, Jacob D. Estes, Hans-Peter Kiem
Publikováno v:
Stem Cell Reports, Vol 13, Iss 1, Pp 91-104 (2019)
Summary: Myeloid-differentiated hematopoietic stem cells (HSCs) have contributed to a number of novel treatment approaches for lysosomal storage diseases of the central nervous system (CNS), and may also be applied to patients infected with HIV. We q
Externí odkaz:
https://doaj.org/article/4ca7ae8953f54b429b0918e4417bc4a9
Autor:
Olivier Humbert, Frieda Chan, Yogendra S. Rajawat, Troy R. Torgerson, Christopher R. Burtner, Nicholas W. Hubbard, Daniel Humphrys, Zachary K. Norgaard, Patricia O'Donnell, Jennifer E. Adair, Grant D. Trobridge, Andrew M. Scharenberg, Peter J. Felsburg, David J. Rawlings, Hans-Peter Kiem
Publikováno v:
Blood Advances, Vol 2, Iss 9, Pp 987-999 (2018)
Abstract: Hematopoietic stem-cell gene therapy is a promising treatment of X-linked severe combined immunodeficiency disease (SCID-X1), but currently, it requires recipient conditioning, extensive cell manipulation, and sophisticated facilities. With
Externí odkaz:
https://doaj.org/article/3e55cf5967d441c1ad4a379d1df78d1a
Autor:
Olivier Humbert, Christopher W. Peterson, Zachary K. Norgaard, Stefan Radtke, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 75-86 (2018)
Reactivation of fetal hemoglobin (HbF) is a promising approach for the treatment of β-hemoglobinopathies and the targeting of genes involved in HbF regulation is under intensive investigation. Here, we established a nonhuman primate (NHP) transplant
Externí odkaz:
https://doaj.org/article/84f38e172562412c8121e45e23d6a4d9
Autor:
Kevin G. Haworth, Christina Ironside, Zachary K. Norgaard, Willimark M. Obenza, Jennifer E. Adair, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 17-30 (2017)
Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successfu
Externí odkaz:
https://doaj.org/article/ce6c440911114a7aafd032a64124b80b
Autor:
Elizabeth K. Schmidt, Roberta A. Mittelstaedt, Timothy W. Robison, Xuefei Cao, Ying Chen, Wei Sun, Rebecca Wynne, Yiying Wang, Levan Muskhelishvili, Charles C. Valentine, Thomas H. Smith, Lindsey N. Williams, Zachary K Norgaard, Robert H. Heflich, Kelly Davis, Jesse J. Salk, Jeffry Yaplee
Publikováno v:
Environmental and Molecular Mutagenesis
The organotypic human air‐liquid‐interface (ALI) airway tissue model has been used as an in vitro cell culture system for evaluating the toxicity of inhaled substances. ALI airway cultures are highly differentiated, which has made it challenging
Autor:
Rosana Risques, Thomas H. Smith, Zachary K. Norgaard, Roniz Katz, Fang Yin Lo, Elizabeth K. Schmidt, Jacob E. Higgins, Martin Filipits, Intidhar Labidi-Galy, David Cibula, Lukáš Dostálek, Gabriel Jelenek, Magdalena Plch, Jiří Bouda, Alexander Mustea, Mateja Condic, Sabine Grill, Noreen Gleeson, Peter Oppelt, Gunda Pristauz-Telsnigg, Adriaan Vanderstichele, Siel Obrecht, Adam Rosenthal, Paul Speiser, Jesse Salk
Publikováno v:
Cancer Research. 82:PR005-PR005
Background: High grade serous ovarian cancer (HGSC), the most common and aggressive type of ovarian cancer, is nearly always driven by TP53 mutations, which can be detected in uterine lavages using ultra-deep duplex sequencing. While this finding sup
Autor:
Rosana Risques, Thomas H. Smith, Zachary K. Norgaard, Roniz Katz, Fang Yin Lo, Elizabeth K. Schmidt, Jacob E. Higgins, Martin Filipits, Intidhar Labidi-Galy, David Cibula, Lukáš Dostálek, Gabriel Jelenek, Magdalena Plch, Jiří Bouda, Alexander Mustea, Mateja Condic, Sabine Grill, Noreen Gleeson, Peter Oppelt, Gunda Pristauz-Telsnigg, Adriaan Vanderstichele, Siel Obrecht, Adam Rosenthal, Paul Speiser, Jesse Salk
Publikováno v:
Cancer Research. 82:A008-A008
This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR005) of the Conference Proceedings. Citation Format: Rosana Risques, Thomas H. Smith, Zachary K. Norgaard,
Autor:
Olivier Humbert, Christopher W. Peterson, Stefan Radtke, Hans-Peter Kiem, Zachary K. Norgaard
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 75-86 (2018)
Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 75-86 (2018)
Reactivation of fetal hemoglobin (HbF) is a promising approach for the treatment of β-hemoglobinopathies and the targeting of genes involved in HbF regulation is under intensive investigation. Here, we established a nonhuman primate (NHP) transplant
Autor:
Kevin G. Haworth, Willimark M. Obenza, Christina Ironside, Jennifer E. Adair, Hans-Peter Kiem, Zachary K. Norgaard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 6, Iss C, Pp 17-30 (2017)
Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successfu
Autor:
Zachary K. Norgaard, Swati Singh, Socheath Khim, Jennifer E. Adair, Brenda Seymour, David J. Rawlings, Matthew M. Wielgosz, Denny Liggitt, Karen Sommer, Arthur W. Nienhuis, Iram F. Khan, Hans-Peter Kiem
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 1-16 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 1-16 (2017)
Wiskott-Aldrich syndrome (WAS) is a life-threatening immunodeficiency caused by mutations within the WAS gene. Viral gene therapy to restore WAS protein (WASp) expression in hematopoietic cells of patients with WAS has the potential to improve outcom