Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary J. Frangos"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Neurotransmitter sodium symporters (NSS) are a subfamily of SLC6 transporters responsible for regulating neurotransmitter signalling. They are a major target for psychoactive substances including antidepressants and drugs of abuse, prompting substant
Externí odkaz:
https://doaj.org/article/59be87d5f5c9496f8c74f204583d012a
Autor:
Shannon N Mostyn, Katie A Wilson, Alexandra Schumann-Gillett, Zachary J Frangos, Susan Shimmon, Tristan Rawling, Renae M Ryan, Megan L O'Mara, Robert J Vandenberg
Publikováno v:
eLife, Vol 8 (2019)
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in
Externí odkaz:
https://doaj.org/article/e4b5579816404d49a4828b1847e2f1d9
Autor:
Zachary J. Frangos, Katie A. Wilson, Heather M. Aitken, Ryan Cantwell Chater, Robert J. Vandenberg, Megan L. O’Mara
Publikováno v:
Life Science Alliance. 6:e202201708
Membrane cholesterol binds to and modulates the function of various SLC6 neurotransmitter transporters, including stabilizing the outward-facing conformation of the dopamine and serotonin transporters. Here, we investigate how cholesterol binds to Gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda0e0753b84bd0d5dfd10de58ce4fe3
https://doi.org/10.26508/lsa.202201708
https://doi.org/10.26508/lsa.202201708
Autor:
Tristan Rawling, Katie A. Wilson, Susan Shimmon, Zachary J. Frangos, Megan L. O'Mara, Shannon N. Mostyn, Robert J. Vandenberg
The human glycine transporter 2 (GlyT2 or SLC6A5) has emerged as a promising drug target for the development of new analgesics to manage chronic pain. N-acyl amino acids inhibit GlyT2 through binding to an allosteric binding site to produce analgesia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d9584a64bb3ad1628de5aaddcdb857
https://doi.org/10.1101/2020.09.10.290908
https://doi.org/10.1101/2020.09.10.290908
Autor:
Alexandra Schumann-Gillett, Renae M. Ryan, Susan Shimmon, Robert J. Vandenberg, Megan L. O'Mara, Katie A. Wilson, Shannon N. Mostyn, Tristan Rawling, Zachary J. Frangos
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
The treatment of chronic pain is poorly managed by current analgesics, and there is a need for new classes of drugs. We recently developed a series of bioactive lipids that inhibit the human glycine transporter GlyT2 (SLC6A5) and provide analgesia in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86da3344d6491df8449e1c31d58838f
https://hdl.handle.net/10453/136615
https://hdl.handle.net/10453/136615
Autor:
Subhodeep Sarker, Tristan Rawling, Irina Vetter, Zachary J. Frangos, Arsalan Yousuf, MacDonald J. Christie, Renae M. Ryan, Susan Shimmon, Robert J. Vandenberg, Sarasa A. Mohammadi, Shannon N. Mostyn
© 2019 American Chemical Society. Inhibitors that target the glycine transporter 2, GlyT2, show promise as analgesics, but may be limited by their toxicity through complete or irreversible binding. Acyl-glycine inhibitors, however, are selective for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1847822f8fceca97335d7ae971b592
https://europepmc.org/articles/PMC6420064/
https://europepmc.org/articles/PMC6420064/
Autor:
Shannon N. Mostyn, Robert J. Vandenberg, Megan L. O'Mara, Tristan Rawling, Zachary J. Frangos, Katie A. Wilson, Susan Shimmon
Publikováno v:
The Journal of Biological Chemistry
The role of lipids in modulating membrane protein function is an emerging and rapidly growing area of research. The rational design of lipids that target membrane proteins for the treatment of pathological conditions is a novel extension in this fiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27163988df5b7584427e0e0e37e593f5
https://doi.org/10.1016/j.jbc.2021.100282
https://doi.org/10.1016/j.jbc.2021.100282
Publikováno v:
Int Dent J
Background The Internet has transformed the way in which people approach their health care, with online resources becoming a primary source of health information. Little work has assessed the quality of online information regarding community water fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ee44a769a8149844e091d30b454b57
https://pubmed.ncbi.nlm.nih.gov/29441567
https://pubmed.ncbi.nlm.nih.gov/29441567
Autor:
Wallach, Izhar1 (AUTHOR), Bernard, Denzil1 (AUTHOR), Nguyen, Kong1 (AUTHOR), Ho, Gregory1 (AUTHOR), Morrison, Adrian1 (AUTHOR), Stecula, Adrian1 (AUTHOR), Rosnik, Andreana1 (AUTHOR), O'Sullivan, Ann Marie1 (AUTHOR), Davtyan, Aram1 (AUTHOR), Samudio, Ben1 (AUTHOR), Thomas, Bill1 (AUTHOR), Worley, Brad1 (AUTHOR), Butler, Brittany1 (AUTHOR), Laggner, Christian1 (AUTHOR), Thayer, Desiree1 (AUTHOR), Moharreri, Ehsan1 (AUTHOR), Friedland, Greg1 (AUTHOR), Truong, Ha1 (AUTHOR), van den Bedem, Henry1 (AUTHOR), Ng, Ho Leung1 (AUTHOR)
Publikováno v:
Scientific Reports. 9/16/2024, Vol. 14 Issue 1, p1-2. 2p.
Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2.
Autor:
Frangos, Zachary J., Wilson, Katie A., Aitken, Heather M., Chater, Ryan Cantwell, Vandenberg, Robert J., O'Mara, Megan L.
Publikováno v:
Life Science Alliance; Apr2023, Vol. 6 Issue 4, p1-17, 17p