Výsledky vyhledávání - "Zachary J. Feiger"

Induction of Cyclin D2 in Rat Granulosa Cells Requires FSH-dependent Relief from FOXO1 Repression Coupled with Positive Signals from Smad

Autor: Evelyn T. Maizels, Carl A. Peters, Hena Alam, Young-Kyu Park, J. Larry Jameson, Eun Jig Lee, Terry G. Unterman, Teresa K. Woodruff, Zachary J. Feiger, Mary Hunzicker-Dunn

Publikováno v: Journal of Biological Chemistry. 280:9135-9148

Ovarian follicles undergo exponential growth in response to follicle-stimulating hormone (FSH), largely as a result of the proliferation of granulosa cells (GCs). In vitro under serum-free conditions, rat GCs differentiate in response to FSH but do n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c81a7654b5d175dbaa1eae6a6f1ec68
https://doi.org/10.1074/jbc.m409486200

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Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation

Autor: Mary Hunzicker-Dunn, Young-Kyu Park, Shail Ghaey, Evelyn T. Maizels, Hena Alam, Zachary J. Feiger, Navdeep S. Chandel

Publikováno v: Journal of Biological Chemistry. 279:19431-19440

We sought to elucidate the role of AKT in follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation. Our results define a signaling pathway in GCs whereby the inactivating phosphorylation of tuberin downstream of phosphatidylino

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478029d2161bf53165ac4546123fb64a
https://doi.org/10.1074/jbc.m401235200

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