Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Zachary J. Cartun"'
Autor:
Laura Z. Rassenti, Zachary J. Cartun, Elisa Ten Hacken, Prajish Iyer, Meiling Jin, Kevyn Hart, Lili Wang, Catherine J. Wu, Ruben D. Carrasco, Donna Neuberg, Bo Zhang, Thomas J. Kipps
Publikováno v:
Blood. 136:4-5
RNA splicing factor SF3B1 is one of the most recurrently mutated genes in chronic lymphocytic leukemia (CLL), but expression of this mutation alone in murine B cells does not result in CLL. This gene mutation is often subclonal and associated with po
Autor:
Adrian Wiestner, Fara Faye Regis, Lili Wang, Jing Sun, Esther A. Obeng, Rutendo Gambe, Jean Fan, Shanye Yin, Angela N. Brooks, Amaro Taylor-Weiner, Emanuela M. Ghia, Carrie Cibulskis, Robin Reed, Thomas J. Kipps, Donna Neuberg, Ignaty Leshchiner, Ruben D. Carrasco, Mark D. Fleming, Zachary J. Cartun, James A. DeCaprio, Benjamin L. Ebert, Youzhong Wan, Elisa Ten Hacken, Sarah E. M. Herman, Catherine J. Wu, Laura Z. Rassenti, Gad Getz, Aina Zurita Martinez, Dean R. Campagna
Publikováno v:
Cancer cell, vol 35, iss 2
SF3B1 is recurrently mutated in chronic lymphocytic leukemia (CLL), but its role in the pathogenesis of CLL remain elusive. Here, we show that conditional expression of Sf3b1-K700E mutation in mouse B cells disrupts pre-mRNA splicing, alters cell dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a552fc6456f9a24e7ec4a5a8d172d93c
https://escholarship.org/uc/item/101965h5
https://escholarship.org/uc/item/101965h5
Autor:
Andreas Gnirke, Bastian Schilling, Qian Zhan, Dirk Schadendorf, Alexander Meissner, Taha Merghoub, Levi A. Garraway, George F. Murphy, Patrick Ryan Potts, Nir Hacohen, Ying Huang, Patrick C. Lee, Diana Miao, Clyde Bango, Arman W. Mohammad, Christine G. Lian, Catherine J. Wu, Jedd D. Wolchok, Daniel Gusenleitner, Eliezer M. Van Allen, Derin B. Keskin, Donna Neuberg, Pavan Bachireddy, Rupert Langer, Christina Galonska, Kendell Clement, Zachary J. Cartun, Jeffrey S. Weber, Alexandra Snyder, Mehrtash Babadi, F. Stephen Hodi, Sachet A. Shukla
Publikováno v:
Cell
CTLA-4 immune checkpoint blockade is clinically effective in a subset of patients with metastatic melanoma. We identify a subcluster of MAGE-A cancer-germline antigens, located within a narrow 75 kb region of chromosome Xq28, that predicts resistance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956467af1a74aa43743ac16b6f1b8c83
Autor:
Zachary J. Cartun, Mike Thomas, Silvia Buonamici, Donna Neuberg, Lili Wang, Jing Deng, Fara Faye Regis, Anthony Letai, Kaitlyn Baranowski, Ruben D. Carrasco, Catherine J. Wu, Elisa Ten Hacken
Publikováno v:
Clinical Cancer Research. 23:29-29
The spliceosome component SF3B1 is among the most frequently mutated genes in CLL (Landau et al. Nature 2015), and its mutations are associated with transcriptomic changes in numerous pathways involved in the regulation of CLL-cell survival (Wang et
Autor:
Catherine J. Wu, Amaro Taylor-Weiner, Jaegil Kim, Angela N. Brooks, Donna Neuberg, Gad Getz, Jing Sun, Benjamin L. Ebert, Zachary J. Cartun, Mark D. Fleming, Ruben D. Carrasco, Lili Wang
Publikováno v:
Cancer Research. 77:2449-2449
Large-scale cancer sequencing of primary chronic lymphocytic leukemia (CLL) has identified SF3B1, an RNA splicing factor, as one of the most frequently mutated CLL genes. SF3B1 mutations localize to a hotspot (>50% at K700E site) and highly co-occur