Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Zachary J Faber"'
Autor:
Stevephen Hung, Alina Saiakhova, Zachary J Faber, Cynthia F Bartels, Devin Neu, Ian Bayles, Evelyn Ojo, Ellen S Hong, W Dean Pontius, Andrew R Morton, Ruifu Liu, Matthew F Kalady, David N Wald, Sanford Markowitz, Peter C Scacheri
Publikováno v:
eLife, Vol 8 (2019)
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to
Externí odkaz:
https://doaj.org/article/a8619f27054e40b480d81c4ee548d4dd
Autor:
W. Dean Pontius, Ellen S. Hong, Zachary J. Faber, Jeremy Gray, Craig D. Peacock, Ian Bayles, Katreya Lovrenert, Diana H. Chin, Berkley E. Gryder, Cynthia F. Bartels, Peter C. Scacheri
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most
Externí odkaz:
https://doaj.org/article/6bb55550fb1640888f084ae083dc4872
Autor:
Devin Neu, Stevephen Hung, Cynthia F. Bartels, Zachary J. Faber, Katreya Lovrenert, W. Dean Pontius, Laura Morgan, Maharshi Chakraborty, Will Liao, Diana Chin, Ellen S. Hong, Jeremy Gray, Victor Moreno, Matthew Kalady, Ulrike Peters, Berkley Gryder, Richard C. Sallari, Peter C. Scacheri
Transposable elements become increasingly active in both cancerous and aging cells, driven by loss of DNA methylation as cells divide. Here we leverage the epigenomes of colon cancers with matched adjacent tissue, in addition to non-cancerous normals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2b7b28d2b35a1559efaa7c0ad5fa31b
https://doi.org/10.1101/2023.05.17.541189
https://doi.org/10.1101/2023.05.17.541189
Autor:
W. Dean Pontius, Ellen S. Hong, Zachary J. Faber, Jeremy Gray, Craig Peacock, Ian Bayles, Katreya Lovrenert, Cynthia F. Bartels, Peter C. Scacheri
The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15805f7a5613fcc61481252ddf21eb20
https://doi.org/10.1101/2022.11.15.516627
https://doi.org/10.1101/2022.11.15.516627
Autor:
Ellen S. Hong, W Dean Pontius, Yuriy Fedorov, Cynthia F. Bartels, Peter C. Scacheri, Jaret M. Karnuta, Jim Lu, Małgorzata Krajewska, Brian P. Rubin, James J. Morrow, Ian Bayles, Rani E. George, Alina Saiakhova, Drew J. Adams, Zachary J Faber
Publikováno v:
Journal of Clinical Investigation. 129:4377-4392
Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a system that enabled preclinical screening of compounds against metastatic OS cells in the contex
Autor:
Mathieu Lupien, Shashirekha Shetty, Qiulian Wu, Megan S. Piazza, Xiuxing Wang, Stephane Angers, Brian P. Rubin, Stephen C. Mack, Jeremy N. Rich, Ryan C. Gimple, Zachary J Faber, Nergiz Dogan-Artun, Peter B. Dirks, Richard C Sallari, Kevin C. Allan, Andrew R. Morton, Graham MacLeod, Cynthia F. Bartels, Peter C. Scacheri
Publikováno v:
Cell
Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant co-amplification of non-coding DNA beyond the boundaries of amplified oncogenes across five cancer types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8b917dabe6f566ee78dae40b5c9149
https://europepmc.org/articles/PMC7241652/
https://europepmc.org/articles/PMC7241652/
Autor:
Alina Saiakhova, Ellen S. Hong, Matthew F. Kalady, Andrew R. Morton, W Dean Pontius, Zachary J Faber, Stevephen Hung, Cynthia F. Bartels, Ian Bayles, Evelyn Ojo, Peter C. Scacheri, Sanford D. Markowitz, David N. Wald, Ruifu Liu, Devin Neu
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to
Autor:
Sanford D. Markowitz, W Dean Pontius, Zachary J Faber, Alina Saiakhova, Matthew F. Kalady, Ruifu Liu, Stevephen Hung, Cynthia F. Bartels, Ian Bayles, Evelyn Ojo, Peter C. Scacheri, Devin Neu, David N. Wald, Ellen S. Hong, Andrew R. Morton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4037e9b0ca0befaee307b80a8b33ecde
https://doi.org/10.7554/elife.40760.032
https://doi.org/10.7554/elife.40760.032
Autor:
Ellen S. Hong, Devin Neu, David N. Wald, Sanford D. Markowitz, Andrew R. Morton, Alina Saiakhova, Stevephen Hung, Cynthia F. Bartels, Ian Bayles, Evelyn Ojo, Matthew F. Kalady, Peter C. Scacheri, Ruifu Liu, W Dean Pontius, Zachary J Faber
Commonly-mutated genes have been found for many cancers, but less is known about mutations incis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a07ac1c689368690abcf38de42cdd0
https://doi.org/10.1101/411264
https://doi.org/10.1101/411264
Autor:
Michael N. Edmonson, Sheila A. Shurtleff, Erin Hedlund, John Easton, Xueyuan Cao, Guangchun Song, Jeffery M. Klco, Heather L. Mulder, Konstanze Döhner, Li Dong, Yu Liu, Robert Huether, Yongjin Li, Jinghui Zhang, Jeffrey E. Rubnitz, Zhongling Cai, Hartmut Döhner, Kristy Boggs, Evan Parganas, Richard K. Wilson, Joy Nakitandwe, Lucinda Fulton, Tanja A. Gruber, Ina Radtke, Peter Paschka, Elaine R. Mardis, Ching-Hon Pui, Bhavin Vadodaria, Jinjun Cheng, Li Ding, Michael Rusch, Donald Yergeau, James R. Downing, Lars Bullinger, Xiang Chen, Amanda Larson Gedman, Jyh Rong Chao, Jianmin Wang, Stanley Pounds, Anna Andersson, Robert S. Fulton, Gang Wu, Charles G. Mullighan, Jing Ma, Richard F. Schlenk, Michael P. Walsh, Jinjun Dang, Chunxu Qu, Zachary J Faber
Publikováno v:
Nature genetics. 48(12)
Acute myeloid leukemia (AML) comprises a heterogeneous group of leukemias frequently defined by recurrent cytogenetic abnormalities, including rearrangements involving subunits of the core-binding factor (CBF) transcriptional complex. To better under