Výsledky vyhledávání - "Zachary I. Blume"

Akademický článek

Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia

Autor: Whitney A. Thiel, Emma J. Esposito, Anna P. Findley, Zachary I. Blume, Diana M. Mitchell

Publikováno v: Biology Open, Vol 11, Iss 1 (2022)

Transcriptome analyses performed in both human and zebrafish indicate strong expression of Apoe and Apoc1 by microglia. Apoe expression by microglia is well appreciated, but Apoc1 expression has not been well-examined. PPAR/RXR and LXR/RXR receptors

Externí odkaz: https://doaj.org/article/f0d6ce62e6a74552a0a74b87d9e400b1

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Compensatory engulfment and Müller glia reactivity in the absence of microglia

Autor: Whitney A. Thiel, Zachary I. Blume, Diana M. Mitchell

Publikováno v: Glia

Microglia are known for important phagocytic functions in the vertebrate retina. Reports also suggest that Müller glia have phagocytic capacity, though the relative levels and contexts in which this occurs remain to be thoroughly examined. Here, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d12364eb56dfca1fa6012a23cf7774
https://europepmc.org/articles/PMC9081278/

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Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling

Autor: Jared M. Lambert, Diana M. Mitchell, Zachary I Blume, Anna G Lovel

Publikováno v: Dev Dyn

BackgroundMicroglia colonize the developing vertebrate central nervous system coincident with detection of developmental apoptosis. Our understanding of apoptosis in intact tissue in relation to microglial clearance of dying cells is largely based on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ed8fd5f54249490878dde96fe9a7d8
https://doi.org/10.1101/2020.01.30.925859

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