Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Zachary Herrera"'
Publikováno v:
Angewandte Chemie. 133:8357-8364
C(sp3 )-Cl bonds are present in numerous biologically active small molecules, and an ideal route for their preparation is by the chlorination of a C(sp3 )-H bond. However, most current methods for the chlorination of C(sp3 )-H bonds are insufficientl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aa84b485a020cd77d875205e2448d3
https://doi.org/10.1002/ange.202016548
https://doi.org/10.1002/ange.202016548
Publikováno v:
Angew Chem Int Ed Engl
C(sp(3))–Cl bonds are present in numerous biologically active small molecules, and an ideal route for their preparation is by the chlorination of a C(sp(3))–H bond. However, most current methods for the chlorination of C(sp(3))–H bonds are insu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c15c4f165b48010f068333e332db946
https://pubmed.ncbi.nlm.nih.gov/33480134
https://pubmed.ncbi.nlm.nih.gov/33480134
Autor:
Michael J. Soth, Kang Le, Maria Emilia Di Francesco, Matthew M. Hamilton, Gang Liu, Jason P. Burke, Chris L. Carroll, Jeffrey J. Kovacs, Jennifer P. Bardenhagen, Christopher A. Bristow, Mario Cardozo, Barbara Czako, Elisa de Stanchina, Ningping Feng, Jill R. Garvey, Jason P. Gay, Mary K. Geck Do, Jennifer Greer, Michelle Han, Angela Harris, Zachary Herrera, Sha Huang, Virginia Giuliani, Yongying Jiang, Sarah B. Johnson, Troy A. Johnson, Zhijun Kang, Paul G. Leonard, Zhen Liu, Timothy McAfoos, Meredith Miller, Pietro Morlacchi, Robert A. Mullinax, Wylie S. Palmer, Jihai Pang, Norma Rogers, Charles M. Rudin, Hannah E. Shepard, Nakia D. Spencer, Jay Theroff, Qi Wu, Alan Xu, Ju Anne Yau, Giulio Draetta, Carlo Toniatti, Timothy P. Heffernan, Philip Jones
Publikováno v:
J Med Chem
Inhibition of glutaminase-1 (GLS-1) hampers the proliferation of tumor cells reliant on glutamine. Known glutaminase inhibitors have potential limitations, and in vivo exposures are potentially limited due to poor physicochemical properties. We initi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b9f179f30ccdc7840fbbad768ec366
https://europepmc.org/articles/PMC9007139/
https://europepmc.org/articles/PMC9007139/
Autor:
Zachary Herrera, Wesley Wu, Joseph L. DeRisi, Seok H. Cho, Katie Baska, Ellen Yeh, Danny Ebert
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 1
The apicoplast is an essential plastid organelle found in Plasmodium parasites which contains several clinically validated antimalarial-drug targets. A chemical rescue screen identified MMV-08138 from the “Malaria Box” library of growth-inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaebf3921d7279f5926d51c989bbdc39
https://doi.org/10.1128/aac.03342-14
https://doi.org/10.1128/aac.03342-14
Publikováno v:
Cell chemical biology. 25(2)
Summary The bifunctional farnesyl/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key branchpoint enzyme in isoprenoid biosynthesis in Plasmodium falciparum (malaria) parasites. Pf FPPS/GGPPS is a validated, high-priority antimalarial drug targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a319eca8f1878b4c38d0616d7eeb90
https://pubmed.ncbi.nlm.nih.gov/29276048
https://pubmed.ncbi.nlm.nih.gov/29276048
SummaryIsoprenoid biosynthesis is essential for Plasmodium falciparum (malaria) parasites and contains multiple validated antimalarial drug targets, including a bifunctional farnesyl and geranylgeranyl diphosphate synthase (FPPS/GGPPS). We identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5d2ee72e13ec1565af710b46fb5590
Autor:
Rod R. Warburton, Cornelius Klöck, Zachary Herrera, Deniz Toksoz, Chaitan Khosla, Thomas R. DiRaimondo, Nicholas S. Hill, Barry L. Fanburg, Krishna Penumatsa
Publikováno v:
ACS Chemical Biology. 9:266-275
Previous studies in human patients and animal models have suggested that transglutaminase 2 (TG2) is upregulated in pulmonary hypertension (PH), a phenomenon that appears to be associated with the effects of serotonin (5-hydroxytryptamine; 5-HT) in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89532a39f04f7d8309c9b80d4d7dfbb5
https://doi.org/10.1021/cb4006408
https://doi.org/10.1021/cb4006408
Publikováno v:
Journal of Medicinal Chemistry
Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the posttranslational modification of glutamine residues on protein or peptide substrates. A growing body of literature has implicated aberrantly regulated activity of TG2 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0405c473a78aba4a22913a76ec546050
https://pubmed.ncbi.nlm.nih.gov/25333388
https://pubmed.ncbi.nlm.nih.gov/25333388