Zobrazeno 1 - 10
of 417
pro vyhledávání: '"Zachary Goodman"'
Autor:
Zobair M. Younossi, Maria Stepanova, Mazen Noureddin, Kris V. Kowdley, Simone I. Strasser, Anita Kohli, Peter Ruane, Mitchell L. Shiffman, Aasim Sheikh, Nadege Gunn, Stephen H. Caldwell, Ryan S. Huss, Robert P. Myers, Vincent Wai‐Sun Wong, Naim Alkhouri, Zachary Goodman, Rohit Loomba
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1201-1211 (2021)
Patient‐reported outcomes (PROs) are important endpoints for clinical trials. The impact of investigational drugs on PROs of patients with advanced nonalcoholic steatohepatitis (NASH) was investigated. Patients with NASH with bridging fibrosis or c
Externí odkaz:
https://doaj.org/article/10bc3bc5921042808f8b0f85eb39a5a0
Autor:
Zobair M Younossi, Vincent Wai‐Sun Wong, Quentin M. Anstee, Manuel Romero‐Gomez, Michael H. Trauner, Stephen A. Harrison, Eric J. Lawitz, Takeshi Okanoue, Marianne Camargo, Kathryn Kersey, Robert P. Myers, Zachary Goodman, Maria Stepanova
Publikováno v:
Hepatology Communications, Vol 4, Iss 11, Pp 1637-1650 (2020)
Fatigue and pruritus are common in patients with chronic liver diseases of all etiologies, but clinical awareness is mostly restricted to those with cholestatic liver diseases. We assessed the impact of fatigue and pruritus on patient‐reported outc
Externí odkaz:
https://doaj.org/article/9b10606dc65d41fca0697ee13b96e183
Autor:
Michael Trauner, Yevgeniy Gindin, Zhaoshi Jiang, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Aliya Gulamhusein, Kris V. Kowdley, Cynthia Levy, Zachary Goodman, Michael P. Manns, Andrew J. Muir, Christopher L. Bowlus
Publikováno v:
JHEP Reports, Vol 2, Iss 1, Pp - (2020)
Background & Aims: A DNA methylation (DNAm) signature derived from 353 CpG sites (the Horvath clock) has been proposed as an epigenetic measure of chronological and biological age. This epigenetic signature is accelerated in diverse tissue types in v
Externí odkaz:
https://doaj.org/article/e1d59672b8dd4d0aa47329db3e2f4a46
Autor:
Laura M Keller, Stephanie Eighmy, Cun Li, Lauryn Winter, Jay Kerecman, Zachary Goodman, Naveen Mittal, Cynthia L Blanco
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0228985 (2020)
Parenteral Nutrition (PN) Associated Liver Disease (PNALD) affects up to 60% of neonates; however, techniques for diagnosing and monitoring disease progression remain limited. The neonatal baboon model may provide a unique opportunity to identify ser
Externí odkaz:
https://doaj.org/article/7c8d8785f1024857ba65e9323b7caf06
Autor:
Clare Relton, Maarten Burbach, Clive Collett, James Flory, Sophie Gerlich, Soren Holm, Amanda Hunn, Scott Y. Kim, Linda Kwakkenbos, Anne May, Jon Nicholl, Danny Young-Afat, Shaun Treweek, Rudolf Uher, Tjeerd van Staa, Joanne van der Velden, Helena Verkooijen, Andrew Vickers, Sophie Welch, Merrick Zwarenstein, Scott Kim, Zachary Goodman, Søren Holm, Anne M. May, Danny A. Young-Afat, Johannes P. Burbach, Carla H. van Gils, Rieke van der Graaf, Helena M. Verkooijen, Laura C. Coates, William Tillett, David Torgerson, Neil McHugh, Peter Taylor, Lesley Brown, Anne Heaven, John Young, Andrew Clegg, Kate Chatfield, Roxanne Gal, Evelyn M. Monninkhof, Danny A. Young Afat, Rolf H. H. Groenwold, Marie-Eve Carrier, Brett D. Thombs, the SPIN investigators, Joanne M. van der Velden, A. Sophie Gerlich, Jorrit-Jan Verlaan, Alice M. Couwenberg, Johannes P. M. Burbach, Emily Peckham, Suzanne Crossland, Tom Hughes, Alisha O’Connor, Imogen Sargent, Simon Gilbody
Publikováno v:
Trials, Vol 18, Iss S2, Pp 1-10 (2017)
Externí odkaz:
https://doaj.org/article/b8214db6fe2d43d19f2836fb7150b03b
Autor:
Rohini Mehta, Gladys Shaw, Peter Masschelin, Sean Felix, Munkzhul Otgonsuren, Ancha Baranova, Zachary Goodman, Zobair Younossi
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199294 (2018)
Non-alcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and major cause of chronic liver disease in developed countries. Its prevalence is increasing in parallel with the prevalence of obesity and other components o
Externí odkaz:
https://doaj.org/article/43213bae2ba64c369051911b17d881b4
Autor:
Zobair M. Younossi, Maria Stepanova, Sean Felix, Thomas Jeffers, Elena Younossi, Zachary Goodman, Andrei Racila, Brian P. Lam, Linda Henry
Publikováno v:
Alimentary Pharmacology & Therapeutics. 57:1417-1422
Autor:
Arun J. Sanyal, Patricia Lopez, Eric J. Lawitz, Kathryn J. Lucas, Juergen Loeffler, Won Kim, George B. B. Goh, Jee-Fu Huang, Carla Serra, Pietro Andreone, Yi-Cheng Chen, Stanley H. Hsia, Vlad Ratziu, Diego Aizenberg, Hiroshi Tobita, Aasim M. Sheikh, John M. Vierling, Yoon Jun Kim, Hideyuki Hyogo, Dean Tai, Zachary Goodman, Felicity Schaefer, Ian R. I. Carbarns, Sophie Lamle, Miljen Martic, Nikolai V. Naoumov, Clifford A. Brass
Publikováno v:
Nature Medicine. 29:392-400
The multimodal activities of farnesoid X receptor (FXR) agonists make this class an attractive option to treat nonalcoholic steatohepatitis. The safety and efficacy of tropifexor, an FXR agonist, in a randomized, multicenter, double-blind, three-part
Autor:
Mazen Noureddin, Zachary Goodman, Dean Tai, Elaine L. K. Chng, Yayun Ren, Pol Boudes, Harold Shlevin, Guadalupe Garcia‐Tsao, Stephen A. Harrison, Naga P. Chalasani
Publikováno v:
Alimentary Pharmacology & Therapeutics. 57:409-417
Autor:
Hannah C. Broos, Caitlin A. Stamatis, Zachary Goodman, Maria M. Llabre, Michael Zvolensky, Kiara R. Timpano
Publikováno v:
Anxiety, Stress, & Coping. 36:241-258
There is evidence for the impact of emotional intolerance on reactivity to stressors, but it is unknown whether the level of situational uncertainty may moderate this relationship. We examined whether situational uncertainty moderated the relationshi