Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Zachary F. Mandell"'
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT The Bacillus subtilis genome encodes four 3′ exoribonucleases: polynucleotide phosphorylase (PNPase), RNase R, RNase PH, and YhaM. Previous work showed that PNPase, encoded by the pnpA gene, is the major 3′ exonuclease involved in mRNA t
Externí odkaz:
https://doaj.org/article/4bfff2e6f17e44d68c5b4ed1d6b35d57
Autor:
Helen Yakhnin, Alexander V. Yakhnin, Brandon L. Mouery, Zachary F. Mandell, Catherine Karbasiafshar, Mikhail Kashlev, Paul Babitzke
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Macrolide antibiotics bind to 23S rRNA within the peptide exit tunnel of the ribosome, causing the translating ribosome to stall when an appropriately positioned macrolide arrest motif is encountered in the nascent polypeptide. Tylosin is a
Externí odkaz:
https://doaj.org/article/9d25a70e7bc14faa966d3a8d0b96310c
Autor:
Zachary F Mandell, Reid T Oshiro, Alexander V Yakhnin, Rishi Vishwakarma, Mikhail Kashlev, Daniel B Kearns, Paul Babitzke
Publikováno v:
eLife, Vol 10 (2021)
NusA and NusG are transcription factors that stimulate RNA polymerase pausing in Bacillus subtilis. While NusA was known to function as an intrinsic termination factor in B. subtilis, the role of NusG in this process was unknown. To examine the indiv
Externí odkaz:
https://doaj.org/article/1f0c0d49764849a08ca298f3f24f699d
Autor:
Zachary F. Mandell, Rishi K. Vishwakarma, Helen Yakhnin, Katsuhiko S. Murakami, Mikhail Kashlev, Paul Babitzke
Publikováno v:
Nature Microbiology. 7:1918-1931
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::734028448a7ae13c28e9c1eb1967c0a8
https://doi.org/10.1038/s41564-022-01240-7
https://doi.org/10.1038/s41564-022-01240-7
Publikováno v:
Transcription. 13:96-108
Transcription termination is known to occur via two mechanisms in bacteria, intrinsic termination (also frequently referred to as Rho-independent or factor-independent termination) and Rho-dependent termination. Based primarily on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df7b8dd0d604d53390768ead1d30270
https://doi.org/10.1080/21541264.2022.2127602
https://doi.org/10.1080/21541264.2022.2127602
Autor:
Hiraku, Takada, Zachary F, Mandell, Helen, Yakhnin, Anastasiya, Glazyrina, Shinobu, Chiba, Tatsuaki, Kurata, Kelvin J Y, Wu, Ben I C, Tresco, Andrew G, Myers, Gemma C, Aktinson, Paul, Babitzke, Vasili, Hauryliuk
Publikováno v:
Nucleic acids research. 50(11)
Since antibiotic resistance is often associated with a fitness cost, bacteria employ multi-layered regulatory mechanisms to ensure that expression of resistance factors is restricted to times of antibiotic challenge. In Bacillus subtilis, the chromos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d02a4d99bc9d83327b448d55cc57303
https://pubmed.ncbi.nlm.nih.gov/35699226
https://pubmed.ncbi.nlm.nih.gov/35699226
Autor:
Oshadhi T. Jayasinghe, Zachary F. Mandell, Alexander V. Yakhnin, Mikhail Kashlev, Paul Babitzke
Publikováno v:
J Bacteriol
Transcription elongation is a highly processive process that is punctuated by RNA polymerase (RNAP) pausing. Long-lived pauses can provide time for diverse regulatory events to occur, which play important roles in modulating gene expression. Transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c3fb38e9c768a67c0140dd8a540e0c
https://europepmc.org/articles/PMC9112975/
https://europepmc.org/articles/PMC9112975/
Autor:
Paul Babitzke, Helen Yakhnin, Zachary F. Mandell, Alexander V. Yakhnin, Peter C. FitzGerald, Mikhail Kashlev, Carl E. Mcintosh, Maria L. Kireeva, Joshua Turek-Herman
Publikováno v:
Proceedings of the National Academy of Sciences. 117:21628-21636
Transcription is punctuated by RNA polymerase (RNAP) pausing. These pauses provide time for diverse regulatory events that can modulate gene expression. Transcription elongation factors dramatically affect RNAP pausing in vitro, but the genome-wide r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0197c0657ce31cca51b149ec511d9bae
https://doi.org/10.1073/pnas.2006873117
https://doi.org/10.1073/pnas.2006873117
Autor:
Alexander V, Yakhnin, Peter C, FitzGerald, Carl, McIntosh, Helen, Yakhnin, Maria, Kireeva, Joshua, Turek-Herman, Zachary F, Mandell, Mikhail, Kashlev, Paul, Babitzke
Publikováno v:
Proc Natl Acad Sci U S A
Transcription is punctuated by RNA polymerase (RNAP) pausing. These pauses provide time for diverse regulatory events that can modulate gene expression. Transcription elongation factors dramatically affect RNAP pausing in vitro, but the genome-wide r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ccef70854ca493196e3e5a867f38f944
https://pubmed.ncbi.nlm.nih.gov/32817529
https://pubmed.ncbi.nlm.nih.gov/32817529