Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Zachary F Mainen"'
Publikováno v:
eLife, Vol 13 (2024)
The ability to persist toward a desired objective is a fundamental aspect of behavioral control whose impairment is implicated in several behavioral disorders. One of the prominent features of behavioral persistence is that its maturation occurs rela
Externí odkaz:
https://doaj.org/article/ace5cf85581e46029177f2f5282a515a
Autor:
International Brain Laboratory, Valeria Aguillon, Dora E Angelaki, Hannah Bayer, Niccolo Bonacchi, Matteo Carandini, Fanny Cazettes, Gaelle Chapuis, Anne K Churchland, Yang Dan, Eric Dewitt, Mayo Faulkner, Hamish Forrest, Laura Haetzel, Michael Häusser, Sonja B Hofer, Fei Hu, Anup Khanal, Christopher Krasniak, Ines Laranjeira, Zachary F Mainen, Guido Meijer, Nathaniel Miska, Thomas D Mrsic-Flogel, Masayoshi Murakami, Jean-Paul Noel, Alejandro Pan-Vazquez, Cyrille Rossant, Joshua Sanders, Karolina Socha, Rebecca Terry, Anne E Urai, Hernando Vergara, Miles Wells, Christian Wilson, Ilana B Witten, Lauren Wool, Anthony M Zador
Publikováno v:
eLife, Vol 11 (2022)
Externí odkaz:
https://doaj.org/article/80fd4519b0bd4d0693ae16b89abbd5f7
Autor:
The International Brain Laboratory, Valeria Aguillon-Rodriguez, Dora Angelaki, Hannah Bayer, Niccolo Bonacchi, Matteo Carandini, Fanny Cazettes, Gaelle Chapuis, Anne K Churchland, Yang Dan, Eric Dewitt, Mayo Faulkner, Hamish Forrest, Laura Haetzel, Michael Häusser, Sonja B Hofer, Fei Hu, Anup Khanal, Christopher Krasniak, Ines Laranjeira, Zachary F Mainen, Guido Meijer, Nathaniel J Miska, Thomas D Mrsic-Flogel, Masayoshi Murakami, Jean-Paul Noel, Alejandro Pan-Vazquez, Cyrille Rossant, Joshua Sanders, Karolina Socha, Rebecca Terry, Anne E Urai, Hernando Vergara, Miles Wells, Christian J Wilson, Ilana B Witten, Lauren E Wool, Anthony M Zador
Publikováno v:
eLife, Vol 10 (2021)
Progress in science requires standardized assays whose results can be readily shared, compared, and reproduced across laboratories. Reproducibility, however, has been a concern in neuroscience, particularly for measurements of mouse behavior. Here, w
Externí odkaz:
https://doaj.org/article/0607a5000b744a54a235fb64586a4ba3
Publikováno v:
eLife, Vol 6 (2017)
Serotonin is implicated in mood and affective disorders. However, growing evidence suggests that a core endogenous role is to promote flexible adaptation to changes in the causal structure of the environment, through behavioral inhibition and enhance
Externí odkaz:
https://doaj.org/article/f4a9288154454057bbc022165afa1be9
Autor:
Patrícia A Correia, Eran Lottem, Dhruba Banerjee, Ana S Machado, Megan R Carey, Zachary F Mainen
Publikováno v:
eLife, Vol 6 (2017)
Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found t
Externí odkaz:
https://doaj.org/article/5bf608e47fe34554b06807242fb574ad
Autor:
Dmitry Kobak, Wieland Brendel, Christos Constantinidis, Claudia E Feierstein, Adam Kepecs, Zachary F Mainen, Xue-Lian Qi, Ranulfo Romo, Naoshige Uchida, Christian K Machens
Publikováno v:
eLife, Vol 5 (2016)
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information
Externí odkaz:
https://doaj.org/article/da5c664057064fb29530937ac13fe0a9
Autor:
Paul C Bush, Zachary F Mainen
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119072 (2015)
Cortical columnar architecture was discovered decades ago yet there is no agreed upon explanation for its function. Indeed, some have suggested that it has no function, it is simply an epiphenomenon of developmental processes. To investigate this pro
Externí odkaz:
https://doaj.org/article/516ab0a6dac94bd28357f10b92c96d84
Autor:
Guillaume P Dugué, Magor L Lörincz, Eran Lottem, Enrica Audero, Sara Matias, Patricia A Correia, Clément Léna, Zachary F Mainen
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105941 (2014)
The inhibition of sensory responsivity is considered a core serotonin function, yet this hypothesis lacks direct support due to methodological obstacles. We adapted an optogenetic approach to induce acute, robust and specific firing of dorsal raphe s
Externí odkaz:
https://doaj.org/article/d7c92b7e48c54924adcc2d6d54f28d12
Publikováno v:
Frontiers in Systems Neuroscience, Vol 3 (2009)
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the
Externí odkaz:
https://doaj.org/article/17e9d8c5f5664934b981d940e40c0bb1
Autor:
Zachary F Mainen
Publikováno v:
Frontiers in Neuroscience, Vol 2 (2008)
Externí odkaz:
https://doaj.org/article/aaf2917de6814118a65878ef0d33f639