Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Zachary E. Potter"'
Autor:
Sujata Chakraborty, Ethan Ahler, Jessica J. Simon, Linglan Fang, Zachary E. Potter, Katherine A. Sitko, Jason J. Stephany, Miklos Guttman, Douglas M. Fowler, Dustin J. Maly
SUMMARYKinase inhibitors are effective cancer therapies but resistance often limits clinical efficacy. Despite the cataloguing of numerous resistance mutations, our understanding of kinase inhibitor resistance is still incomplete. Here, we comprehens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7ae707de4e31560372338c6caa63e24
https://doi.org/10.1101/2021.12.05.471322
https://doi.org/10.1101/2021.12.05.471322
Autor:
Rajarshi Ghosh, B. Gayani K. Perera, Feroz R. Papa, Venkata Narayana Vidadala, Vincent C. Auyeung, Zachary E. Potter, Alina Olivier, Julie Zikherman, Jae-Hong Kim, Dustin J. Maly, James L. Mueller, Bradley J. Backes, Hannah C. Feldman
Publikováno v:
Nature chemical biology, vol 17, iss 11
The unfolded protein response (UPR) homeostatically matches endoplasmic reticulum (ER) protein-folding capacity to cellular secretory needs. However, under high or chronic ER stress, the UPR triggers apoptosis. This cell fate dichotomy is promoted by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0723837b01d50cfdb07ac11767477d32
https://escholarship.org/uc/item/68f3g7m2
https://escholarship.org/uc/item/68f3g7m2
Autor:
Zachary E. Potter, Linglan Fang, Emily M. Dieter, Dustin J. Maly, Chloe K. Lombard, Sujata Chakraborty
Publikováno v:
J Am Chem Soc
Small molecule inhibitors often only block a subset of the cellular functions of their protein targets. In many cases, how inhibiting only a portion of a multi-functional protein’s functions affects the state of the cell is not well understood. The
Autor:
Jie H Hu, Ted R. Kohler, Nathan Airhart, Sina A. Gharib, Zachary E. Potter, Benjamin F. Cravatt, Tomas Vaisar, David A. Dichek, Kate Fox, Jay W. Heinecke, Roberto F. Nicosia, Melissa M. Dix, Gabriel M. Simon
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown. Objective: By
Rationale: Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown. Objective: By
Autor:
Markus A. Seeliger, Ames C. Register, Sujata Chakraborty, Zachary E. Potter, Linglan Fang, Dustin J. Maly, Jessica Vilas-Boas
Publikováno v:
ACS Chem Biol
Small molecule kinase inhibitors that stabilize distinct ATP binding site conformations can differentially modulate the global conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP binding site contacts are responsible
Publikováno v:
ACS Medicinal Chemistry Letters. 9:563-568
Wnt proteins are secreted morphogens that play critical roles in embryonic development and tissue remodeling in adult organisms. Aberrant Wnt signaling contributes to diseases such as cancer. Wnts are modified by an unusual O-fatty acylation event (O
Autor:
Zachary E. Potter, Sujata Chakraborty, Linglan Fang, Dustin J. Maly, Ho-Tak Lau, Douglas M. Fowler, Miklos Guttman, Shao En Ong
Publikováno v:
Cell Chem Biol
Solution-based structural techniques complement high-resolution structural data by providing insight into the oft-missed links between protein structure and dynamics. Here, we present Parallel Chemoselective Profiling, a solution-based structural met
Autor:
Michael R. Lazear, Sherry Niessen, Shuyan Lu, Sabrina Barbas, Zachary E. Potter, Melissa M. Dix, Douglas Carl Behenna, Matthew Merrill Hayward, Kevin Ryan, Simon Paul Planken, John Charles Kath, Benjamin F. Cravatt, Oleg Brodsky, Ketan S. Gajiwala, Chau Almaden, RoseAnn Ferre
Publikováno v:
Cell Chemical Biology. 24:1388-1400.e7
Summary Patients with non-small cell lung cancers that have kinase-activating epidermal growth factor receptor (EGFR) mutations are highly responsive to first- and second-generation EGFR inhibitors. However, these patients often relapse due to a seco
Publikováno v:
Pan, SC; Pashler, H; Potter, ZE; & Rickard, TC. (2015). Testing enhances learning across a range of episodic memory abilities. Journal of Memory and Language, 83, 53-61. doi: 10.1016/j.jml.2015.04.001. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/24b453hm
© 2015 Elsevier Inc.. Brewer and Unsworth (2012) reported that individuals with low episodic memory ability exhibit a larger testing effect, a finding with potentially important educational implications. We conducted two replication attempts of that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2f5e96b70889c3693a94246b6316613
http://www.escholarship.org/uc/item/24b453hm
http://www.escholarship.org/uc/item/24b453hm
Publikováno v:
Journal of cognitive neuroscience. 27(3)
Human extrastriate cortex contains functional regions that are selective for particular categories such as faces, bodies, and places, but it is unclear whether these category-selective regions are necessary for normal perception of their preferred st