Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zachary E Perlman"'
Autor:
Ulrike S Eggert, Amy A Kiger, Constance Richter, Zachary E Perlman, Norbert Perrimon, Timothy J Mitchison, Christine M Field
Publikováno v:
PLoS Biology, Vol 2, Iss 12, p e379 (2004)
Cytokinesis involves temporally and spatially coordinated action of the cell cycle and cytoskeletal and membrane systems to achieve separation of daughter cells. To dissect cytokinesis mechanisms it would be useful to have a complete catalog of the p
Externí odkaz:
https://doaj.org/article/ef2a4443cda44f7fa9e9b41422504264
Autor:
Timothy J. Mitchison, Kendra S. Burbank, Aaron C. Groen, Daniel S. Fisher, Zachary E. Perlman
Publikováno v:
The Journal of Cell Biology
Anastral meiotic spindles are thought to be organized differently from astral mitotic spindles, but the field lacks the basic structural information required to describe and model them, including the location of microtubule-nucleating sites and minus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db848c60469f6fcf40b163f6583ee92
https://doi.org/10.1083/jcb.200511112
https://doi.org/10.1083/jcb.200511112
Publikováno v:
Biophysical Journal. 88:680-689
Cytoplasmic extracts prepared from Xenopus laevis eggs are used for the reconstitution of a wide range of processes in cell biology, and offer a unique environment in which to investigate the role of cytoplasmic mechanics without the complication of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e09cdc995241211a102c9695c7fc2e
https://doi.org/10.1529/biophysj.104.048025
https://doi.org/10.1529/biophysj.104.048025
Autor:
Timothy J. Mitchison, David T. Miyamoto, Aaron C. Groen, Kendra S. Burbank, Zachary E. Perlman
Publikováno v:
The Journal of Cell Biology
Although mitotic and meiotic spindles maintain a steady-state length during metaphase, their antiparallel microtubules slide toward spindle poles at a constant rate. This “poleward flux” of microtubules occurs in many organisms and may provide pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9ee45ab1a35cbadd615cfdf4335ed1
https://doi.org/10.1083/jcb.200407126
https://doi.org/10.1083/jcb.200407126
Autor:
Lani F. Wu, Timothy J. Mitchison, Steven J. Altschuler, Zachary E. Perlman, Michael D. Slack, Yan Feng
Publikováno v:
Science. 306:1194-1198
We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb92494ffdd174544c3ff7f0547e651
https://doi.org/10.1126/science.1100709
https://doi.org/10.1126/science.1100709
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 6:279-286
We have developed high throughput fluorescence cell imaging methods to screen chemical libraries for compounds with effects on diverse aspects of cell physiology. We describe screens for compounds that arrest cells in mitosis, that block cell migrati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1e0f977648d6fc051ef295d81504e5
https://doi.org/10.2174/138620703106298527
https://doi.org/10.2174/138620703106298527
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
Cyclic peptides offer the possibility of varying both scaffold geometry and R-group functionality. For example, parameters such as ring size and the placement of D-amino acid and proline residues can have a dramatic effect on the conformations of cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c173fff30c17a3b97414d4111c03764
https://pubmed.ncbi.nlm.nih.gov/16213707
https://pubmed.ncbi.nlm.nih.gov/16213707
Autor:
Paul S. Maddox, Edward D. Salmon, Zachary E. Perlman, Timothy J. Mitchison, Lisa A. Cameron, Tarun M. Kapoor, Ankur R. Desai, Ryoma Ohi, Aaron C. Groen
We investigated the mechanism by which meiotic spindles become bipolar and the correlation between bipolarity and poleward flux, using Xenopus egg extracts. By speckle microscopy and computational alignment, we find that monopolar sperm asters do not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b20e29860f2939fd73ea3777582be85
https://europepmc.org/articles/PMC532038/
https://europepmc.org/articles/PMC532038/
Publikováno v:
Chembiochem : a European journal of chemical biology. 6(1)
Maintenance of centrosome number is essential for cell-cycle progression and genomic stability, but investigation of this regulation has been limited by assay difficulty. We present a fully automated image-based centrosome-duplication assay that is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de78ff39c11fc5dccb2c6ced2561eb0c
https://pubmed.ncbi.nlm.nih.gov/15568197
https://pubmed.ncbi.nlm.nih.gov/15568197
Publikováno v:
Progress in cell cycle research. 5
Inhibition of mitosis is a useful strategy for treating diseases involving excessive cell proliferation. Antimitotic drugs currently in clinical use perturb microtubule dynamics and thereby disrupt the function of the mitotic spindle. Protein regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b44aa43a76189a3fc3c906ae41cf6ac
https://pubmed.ncbi.nlm.nih.gov/14593729
https://pubmed.ncbi.nlm.nih.gov/14593729