RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

Autor: Whitney L Johnson, William T Yewdell, Jason C Bell, Shannon M McNulty, Zachary Duda, Rachel J O’Neill, Beth A Sullivan, Aaron F Straight

Publikováno v: eLife, Vol 6 (2017)

Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chr

Externí odkaz: https://doaj.org/article/51427522d6b74dd39ccd9d4d8de6f023

Abstract PO-048: Combined single-T cell clonotyping and phenotyping defines a predictive response signature that identifies patients more likely to respond to therapy

Autor: Ross B. Fulton, Julianna Crivello, Francisco Adrian, Zachary Duda, Dean Lee, Charina Ortega, Roshan Kumar, Liang Schweizer, Matt Delince, Monika Manne, Andreas Raue, Alexandra Staskus

Publikováno v: Cancer Research. 80:PO-048

Immunomodulatory antibodies such as checkpoint inhibitors are showing very promising results in the clinic, but only a minority of patients respond to treatment and it is still challenging to identify these subpopulations. Prospective identification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d65157bf7e480f2592feb7b5359ce53
https://doi.org/10.1158/1538-7445.tumhet2020-po-048

Adaptation and conservation insights from the koala genome

Autor: Danielle Madden, Camilla M. Whittington, Rachel J. O’Neill, Simon Y. W. Ho, Zhiliang Chen, Marilyn B. Renfree, Val Attenbrow, Andrew King, Graham J Etherington, Siobhan Dennison, Parice A. Brandies, David E. Alquezar-Planas, Emma Peel, Amber Gillett, Yuanyuan Cheng, Jennifer A. Marshall Graves, Thomas N. Heider, Greta J. Frankham, Donald J. Colgan, Elizabeth A. Jones, Katherine Belov, Carolyn J. Hogg, Janine E. Deakin, Federica Di Palma, Charles Robin, Catherine E. Grueber, Zachary Duda, Denis O’Meally, Alex D. Greenwood, Jason G. Bragg, Takashi Hayakawa, Clare E. Holleley, Amanda Yoon Yee Chong, Ryan Salinas, Matthew Hobbs, Belinda Wright, Will Nash, Arthur Georges, Kyle M. Ewart, Mark D. B. Eldridge, Adam Polkinghorne, Rebecca N. Johnson, Paul D. Waters, Peter Timms, Shafagh A. Waters, Merran Govendir, Katrina M. Morris, Tonia Russell, Kyriakos Tsangaras, Wilfried Haerty, Hardip R. Patel, Linda E. Neaves, Kristofer M. Helgen, Marc R. Wilkins

Publikováno v: Johnson, R N, O'Meally, D, Chen, Z, Etherington, G J, Ho, S Y W, Nash, W J, Grueber, C E, Cheng, Y, Whittington, C M, Dennison, S, Peel, E, Haerty, W, O'Neill, R J, Colgan, D, Russell, T L, Alquezar-Planas, D E, Attenbrow, V, Bragg, J G, Brandies, P A, Chong, A Y-Y, Deakin, J E, Di Palma, F, Duda, Z, Eldridge, M D B, Ewart, K M, Hogg, C J, Frankham, G J, Georges, A, Gillett, A K, Govendir, M, Greenwood, A D, Hayakawa, T, Helgen, K M, Hobbs, M, Holleley, C E, Heider, T N, Jones, E A, King, A, Madden, D, Graves, J A M, Morris, K M, Neaves, L E, Patel, H R, Polkinghorne, A, Renfree, M B, Robin, C, Salinas, R, Tsangaras, K, Waters, P D & Waters, S A 2018, ' Adaptation and conservation insights from the koala genome ', Nature Genetics, vol. 50, no. 8, pp. 1102-1111 . https://doi.org/10.1038/s41588-018-0153-5
Nature Genetics
Nature genetics, 50:1102–1111

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as ‘vulnerable’ due to habitat loss and widespread disease. We sequenced the koala genome, producing a complete and contiguous marsupial reference genome, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af100bb35684bb2ad32daceb8df8e97
https://hdl.handle.net/20.500.11820/ebdf3be6-51d2-4fde-9233-0c76827d8988

RNA-dependent stabilization of SUV39H1 at constitutive heterochromatin

Autor: Rachel J. O’Neill, Shannon M. McNulty, Whitney L Johnson, Aaron F. Straight, Jason C. Bell, Beth A. Sullivan, Zachary Duda, William T. Yewdell

Publikováno v: eLife, Vol 6 (2017)
eLife

Heterochromatin formed by the SUV39 histone methyltransferases represses transcription from repetitive DNA sequences and ensures genomic stability. How SUV39 enzymes localize to their target genomic loci remains unclear. Here, we demonstrate that chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222c642b3972ffdadad9beefddeb6aca
https://elifesciences.org/articles/25299

Medical sterilization system for NASA Space Exploration Missions

Autor: Zachary Duda, Christopher Graves, Jacquelyn K. S. Nagel, John Gaffney, James Watkins, Quinlan Moore

Publikováno v: 2017 Systems and Information Engineering Design Symposium (SIEDS).

With the goal of sending humans to explore asteroids and Mars soon, NASA aims to improve its current medical capabilities for long duration missions. NASA needs to increase sterilization capabilities while reducing medical payload mass, volume, power

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1eb5821ccc169c5d4d0717b4a5dcb097
https://doi.org/10.1109/sieds.2017.7937731