Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Zachary D Dalebroux"'
Autor:
Cassandra Kamischke, Junping Fan, Julien Bergeron, Hemantha D Kulasekara, Zachary D Dalebroux, Anika Burrell, Justin M Kollman, Samuel I Miller
Publikováno v:
eLife, Vol 8 (2019)
The outer membrane (OM) of Gram-negative bacteria serves as a selective permeability barrier that allows entry of essential nutrients while excluding toxic compounds, including antibiotics. The OM is asymmetric and contains an outer leaflet of lipopo
Externí odkaz:
https://doaj.org/article/3e878368b67745b59962862f6cdc5c94
Autor:
Joseph A. Villanueva, Amy L. Crooks, Toni A. Nagy, Joaquin L. J. Quintana, Zachary D. Dalebroux, Corrella S. Detweiler
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Gram-negative bacteria have a robust cell envelope that excludes or expels many antimicrobial agents. However, during infection, host soluble innate immune factors permeabilize the bacterial outer membrane. We identified two small molecules
Externí odkaz:
https://doaj.org/article/10a9deb02844414790adf04531996640
Autor:
Melina B. Cian, Joshua A. Mettlach, Aaron E. Zahn, Nicole P. Giordano, Keaton E. Minor, Michael McClelland, Zachary D. Dalebroux
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
ABSTRACT Salmonella enterica serovar Typhimurium is an intracellular pathogen that parasitizes macrophages from within a vacuole. The vacuolar environment prompts the bacterium to regulate the lipid composition of the outer membrane (OM), and this in
Externí odkaz:
https://doaj.org/article/b7c9dd1254b4428987a665d348c2f436
Publikováno v:
Infect Immun
Enterobacteriaceae use the periplasmic domain of the conserved inner membrane protein, PbgA/YejM, to regulate lipopolysaccharide (LPS) biogenesis. Salmonella enterica serovar Typhimurium (S. Typhimurium) relies on PbgA to cause systemic disease in mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c45c24f07f2ad561833a836ce23a329
https://pubmed.ncbi.nlm.nih.gov/34780276
https://pubmed.ncbi.nlm.nih.gov/34780276
Salmonella enterica serovar Typhimurium uses PbgA/YejM, a conserved multi-pass transmembrane protein with a soluble periplasmic domain (PD), to balance the glycerophospholipid (GPL) and lipopolysaccharide (LPS) concentrations within the outer membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f9d13252e4bc1bbbcd6f43182db1ae4
https://doi.org/10.1101/2020.12.07.415661
https://doi.org/10.1101/2020.12.07.415661
Publikováno v:
Infect Immun
The outer membrane (OM) of Gram-negative bacteria is an asymmetric lipid bilayer that consists of inner leaflet phospholipids and outer leaflet lipopolysaccharides (LPS). The asymmetric character and unique biochemistry of LPS molecules contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be386fceb85f04e22bb5ba5ffda3564
https://europepmc.org/articles/PMC7309610/
https://europepmc.org/articles/PMC7309610/
Autor:
Melina B, Cian, Nicole P, Giordano, Joshua A, Mettlach, Keaton E, Minor, Zachary D, Dalebroux
Publikováno v:
J Vis Exp
This method works by partitioning the envelope of Gram-negative bacteria into total, inner, and outer-membrane (OM) fractions and concludes with assays to assess the purity of the bilayers. The OM has an increased overall density compared to the inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de9ee2236a6ae44cd7a31f24326b885b
https://pubmed.ncbi.nlm.nih.gov/32338649
https://pubmed.ncbi.nlm.nih.gov/32338649
Autor:
Keaton E. Minor, Nicole P. Giordano, Melina B. Cian, Zachary D. Dalebroux, Joshua A. Mettlach
Publikováno v:
Journal of Visualized Experiments.
This method works by partitioning the envelope of Gram-negative bacteria into total, inner, and outer membrane (OM) fractions and concludes with assays to assess the purity of the bilayers. The OM has an increased overall density compared to the inne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d16fd899573821a0b5a00023848f12ff
https://doi.org/10.3791/60517-v
https://doi.org/10.3791/60517-v
Autor:
Keaton E. Minor, Richard M. Caprioli, Jeffrey M. Spraggins, Emilio S. Rivera, Zachary D. Dalebroux, Kelli L. Boyd, Joshua A. Mettlach, Eric P. Skaar, Lauren D. Palmer
Publikováno v:
Cell reports
SUMMARY Acinetobacter baumannii is a leading cause of ventilator-associated pneumonia and a critical threat due to multidrug resistance. The A. baumannii outer membrane is an asymmetric lipid bilayer composed of inner leaflet glycerophospholipids and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1175fa4d7469b50a150a9f467051b452
https://pubmed.ncbi.nlm.nih.gov/32905776
https://pubmed.ncbi.nlm.nih.gov/32905776
Autor:
Zachary D. Dalebroux, Revathi Masilamani, Melina B. Cian, Keaton E. Minor, Nicole P. Giordano
Publikováno v:
Infection and Immunity
Salmonella enterica serovar Typhimurium (S. Typhimurium) relies upon the inner membrane protein PbgA to enhance outer membrane (OM) integrity and promote virulence in mice. The PbgA transmembrane domain (residues 1 to 190) is essential for viability,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a66220c4932dd1565c70f0a07bb817
https://doi.org/10.1128/iai.00758-19
https://doi.org/10.1128/iai.00758-19