Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model

Autor: Zachary D. C. Burke, Christopher M. Hart, Benjamin V. Kelley, Zeinab Mamouei, Gideon W. Blumstein, Christopher Hamad, Kellyn Hori, Nicolas Cevallos, Christina Villalpando, Nicole Truong, Amr Turkmani, Micah Ralston, Aaron Kavanaugh, Edgar Tenorio, Lawrence M. Kauvar, Alan Li, Nathanael Prunet, Alexandra I. Stavrakis, Nicholas M. Bernthal

Publikováno v: Antibiotics, Vol 12, Iss 10, p 1490 (2023)

Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchor

Externí odkaz: https://doaj.org/article/64cfd71921e94a6890bf163a384a5fc1

The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors

Autor: Alexander L. Lazarides, Harrison R. Ferlauto, Zachary D. C. Burke, Anthony M. Griffin, Bruce D. Leckey, Nicholas M. Bernthal, Jay S. Wunder, Peter C. Ferguson, Julia D. Visgauss, Brian E. Brigman, William C. Eward

Publikováno v: Sarcoma, Vol 2021 (2021)

Synopsis. For ALTs, the utility of chest surveillance has not been well defined. This study suggests that chest imaging does not have a significant role in the surveillance of ALTs. Advanced local imaging and more intensive chest surveillance may be

Externí odkaz: https://doaj.org/article/0714ad67646f473ab52d82be9bf8c10e

How Do the Outcomes of Radiation-Associated Pelvic and Sacral Bone Sarcomas Compare to Primary Osteosarcomas following Surgical Resection?

Autor: Alexander L. Lazarides, Zachary D. C. Burke, Manit K. Gundavda, Rostislav Novak, Michelle Ghert, David A. Wilson, Peter S. Rose, Philip Wong, Anthony M. Griffin, Peter C. Ferguson, Jay S. Wunder, Matthew T. Houdek, Kim M. Tsoi

Publikováno v: Cancers; Volume 14; Issue 9; Pages: 2179

Radiation-associated sarcoma of the pelvis and/or sacrum (RASB) is a rare but challenging disease process associated with a poor prognosis. We hypothesized that patients with RASB would have worse surgical and oncologic outcomes than patients diagnos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e67444e0e82e84885565600f99d5a40
https://pubmed.ncbi.nlm.nih.gov/35565308

Comparison of two fluorescent probes in preclinical non-invasive imaging and image-guided debridement surgery of Staphylococcal biofilm implant infections

Autor: Vishal Hegde, Lloyd S. Miller, Kevin P. Francis, Julie Czupryna, John Hoang, Mafalda Bispo, Zachary D. C. Burke, Marina López-Álvarez, Jan Maarten van Dijl, Francisco Romero Pastrana, Christopher D. Hamad, William L. Sheppard, Marleen van Oosten, Ryan Smith, Nicholas M. Bernthal, Marina M. Sprague, Stephen D. Zoller, Gideon Blumstein, Howard Y. Park

Publikováno v: Scientific reports, vol 11, iss 1
Scientific Reports, 11(1):1622. Nature Publishing Group
Scientific Reports, 11(1). Nature Publishing Group
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

Implant-associated infections are challenging to diagnose and treat. Fluorescent probes have been heralded as a technologic advancement that can improve our ability to non-invasively identify infecting organisms, as well as guide the inexact procedur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8a79694b8e91f6ead5ba3ba5817e72
https://escholarship.org/uc/item/19z0j1p5

Evading the host response: Staphylococcus 'hiding' in cortical bone canalicular system causes increased bacterial burden

Autor: Jeff F. Miller, Gideon Blumstein, Kellyn R. Hori, Christopher D. Hamad, Howard Y. Park, Amanda H. Loftin, Daniel Johansen, Scott I. Simon, Chad R Ishmael, Zachary D. C. Burke, Scott D. Nelson, Ryan Smith, Nicholas M. Bernthal, Vishal Hegde, Rachel M. Borthwell, Samuel J. Clarkson, Marina M. Sprague, William L. Sheppard, Stephen D. Zoller

Publikováno v: Bone research, vol 8, iss 1
Bone Research, Vol 8, Iss 1, Pp 1-11 (2020)
Bone Research

Extremity reconstruction surgery is increasingly performed rather than amputation for patients with large-segment pathologic bone loss. Debate persists as to the optimal void filler for this “limb salvage” surgery, whether metal or allograft bone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2b572720462be1c63523e6f87ddc7b
https://escholarship.org/uc/item/5rt737rf