Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Zachary C. Poss"'
Autor:
Aileen K. Sewell, Zachary C. Poss, Christopher C. Ebmeier, Jeremy R. Jacobsen, William M. Old, Min Han
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104186- (2022)
Summary: The protein kinase complex target of rapamycin complex 1 (TORC1) is a critical mediator of nutrient sensing that has been widely studied in cultured cells and yeast, yet our understanding of the regulatory activities of TORC1 in the context
Externí odkaz:
https://doaj.org/article/ccd050683d6c49628fcd2368a10e3523
Autor:
Zachary C. Poss, Christopher C. Ebmeier, Aaron T. Odell, Anupong Tangpeerachaikul, Thomas Lee, Henry E. Pelish, Matthew D. Shair, Robin D. Dowell, William M. Old, Dylan J. Taatjes
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 436-450 (2016)
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116). We identified over 16,000 quantified phosphosites i
Externí odkaz:
https://doaj.org/article/5d3ce4cfad3a4795abef5531aa404cc4
Autor:
Helen Simpson, Alejandro Ramirez, Eric Bunker, William M. Old, Xun Liu, Steven E. Guard, Jeremy Jacobsen, Julie A. Reisz, Robert E. Sievers, Michael H. B. Stowell, Travis Nemkov, Angelo D'Alessandro, Zachary C. Poss, Douglas A. Chapnick, S. J. Coleman, Kristofor J. Webb, Kerri A. Ball, Christopher C. Ebmeier
Publikováno v:
Molecular & Cellular Proteomics. 21:100262
The non-psychoactive cannabinoid, cannabidiol (CBD), is FDA-approved for treatment of two drug-resistant epileptic disorders, and is seeing increased use among the general public, yet the mechanisms that underlie its therapeutic effects and side-effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83afaa2585790c998c9e70d3edf73072
https://doi.org/10.1016/j.mcpro.2022.100262
https://doi.org/10.1016/j.mcpro.2022.100262
Autor:
Goran Malojčić, Martine Brault, Ines H. Kaltheuner, Lewis C. Cantley, Patrick Deroy, Heeyoun Bunch, Shanhu Hu, Janet Iwasa, Robin D. Dowell, Michael J. Bradley, Christian Clavette, Limei Tao, Peter W. White, Matthias Geyer, Zachary C. Poss, William M. Old, Zachary L. Maas, Shraddha Nayak, Tim-Michael Decker, Christopher C. Ebmeier, Benjamin Erickson, Leah J. Damon, David Bentley, Jenna K. Rimel, Tomer M. Yaron, Jason J. Marineau, Jared L. Johnson, Kristin B. Hamman, Dylan J. Taatjes
Publikováno v:
Genes Dev
CDK7 associates with the 10-subunit TFIIH complex and regulates transcription by phosphorylating the C-terminal domain (CTD) of RNA polymerase II (RNAPII). Few additional CDK7 substrates are known. Here, using the covalent inhibitor SY-351 and quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec82b692d03b26dca0e48986e06f8ae7
https://pubmed.ncbi.nlm.nih.gov/33060135
https://pubmed.ncbi.nlm.nih.gov/33060135
Autor:
Dylan J. Taatjes, Zachary C. Poss, Helen Simpson, Maria Pagratis, William M. Old, Steven E. Guard, Christopher C. Ebmeier
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
The chromosome 21 encoded protein kinase DYRK1A is essential for normal human development. Mutations in DYRK1A underlie a spectrum of human developmental disorders, and increased dosage in trisomy 21 is implicated in Down syndrome related pathologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488515d4ece93d83a3b7808638d72218
https://doi.org/10.1038/s41598-019-42990-5
https://doi.org/10.1038/s41598-019-42990-5
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b39bc6608a35dd6e4c091d7feb2195a
https://doi.org/10.1096/fasebj.2019.33.1_supplement.475.6
https://doi.org/10.1096/fasebj.2019.33.1_supplement.475.6
Autor:
Maria Pagratis, Dylan J. Taatjes, Zachary C. Poss, Christopher C. Ebmeier, William M. Old, Steven E. Guard
Loss of function mutations in the protein kinase DYRK1A lead to a syndromic form of autism spectrum disorder and intellectual disability. Conversely, increased DYRK1A dosage is implicated in atypical brain development and neurocognitive deficits in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe0a72a7e67f2b92f5f1617994f511e6
Autor:
Zachary C. Poss, Maria Pagratis, Helen Simpson, Tristan D. McClure-Begley, Christopher C. Ebmeier, William M. Old
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c182a4ac110d3eebb9a3ee749f29b3d
https://doi.org/10.1096/fasebj.2018.32.1_supplement.662.22
https://doi.org/10.1096/fasebj.2018.32.1_supplement.662.22
Autor:
Dylan J. Taatjes, Andrei V. Krivtsov, Alexander Arefolov, Ge Zou, Ioana Nitulescu, Anupong Tangpeerachaikul, Nancy E. Kohl, Olugbeminiyi O Fadeyi, Roderick T. Bronson, Andrew G. Myers, Andrew L. Kung, Scott A. Armstrong, Henry E. Pelish, Brian B. Liau, Diogo H. Da Silva, Karrie Du, E.V. Schneider, Amanda L. Christie, Madeleine E. Lemieux, Zachary C. Poss, Matthew D. Shair, Deepti Banka, Brittany T. Caruso, Chong Si, Christopher C. Ebmeier, Anja Jestel
Publikováno v:
Nature
Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription factors and chromatin regulators, drive high expression of genes implicated in cell identity and disease, such as lineage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f5a8dd31ffaa438c4711e420afca94
https://doi.org/10.1038/nature14904
https://doi.org/10.1038/nature14904
Autor:
Thomas Lee, Anupong Tangpeerachaikul, Robin D. Dowell, Aaron T. Odell, William M. Old, Henry E. Pelish, Matthew D. Shair, Dylan J. Taatjes, Zachary C. Poss, Christopher C. Ebmeier
Publikováno v:
Cell Reports, Vol 15, Iss 2, Pp 436-450 (2016)
Summary Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale identification of Mediator kinase substrates in human cells (HCT116). We identified over 16,000 quantified phosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2900e6a911767150fdf97007cbfacd85
https://europepmc.org/articles/PMC4833653/
https://europepmc.org/articles/PMC4833653/