Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Zachary C, Ruhe"'
Autor:
Tiffany M. Halvorsen, Fernando Garza-Sánchez, Zachary C. Ruhe, Nicholas L. Bartelli, Nicole A. Chan, Josephine Y. Nguyen, David A. Low, Christopher S. Hayes
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Contact-dependent growth inhibition (CDI) is a common form of interbacterial competition in which cells use CdiA effectors to deliver toxic proteins into their neighbors. CdiA recognizes target bacteria through specific receptor molecules on the cell
Externí odkaz:
https://doaj.org/article/20140678d0ea46d1aef07a4f0b6aad88
Autor:
Steven J. Jensen, Zachary C. Ruhe, August F. Williams, Dinh Q. Nhan, Fernando Garza-Sánchez, David A. Low, Christopher S. Hayes
Publikováno v:
Journal of Bacteriology.
Gram-negative bacteria use type VI secretion systems deliver toxic effector proteins directly into neighboring competitors. Secreting cells also produce specific immunity proteins that neutralize effector activities to prevent autointoxication.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93fbba13ae67204123ec7c7827c36e13
https://doi.org/10.1128/jb.00113-23
https://doi.org/10.1128/jb.00113-23
Autor:
Zachary C. Ruhe, Josephine Y. Nguyen, Jing Xiong, Sanna Koskiniemi, Christina M. Beck, Basil R. Perkins, David A. Low, Christopher S. Hayes
Publikováno v:
mBio, Vol 8, Iss 2 (2017)
ABSTRACT Contact-dependent growth inhibition (CDI) systems encode CdiA effectors, which bind to specific receptors on neighboring bacteria and deliver C-terminal toxin domains to suppress target cell growth. Two classes of CdiA effectors that bind di
Externí odkaz:
https://doaj.org/article/6c77590bbaf34ce5bd811392d96d7a98
Autor:
Zachary C Ruhe, Josephine Y Nguyen, Annette J Chen, Nicole Y Leung, Christopher S Hayes, David A Low
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006145 (2016)
Contact-dependent growth inhibition (CDI) systems are widespread amongst Gram-negative bacteria where they play important roles in inter-cellular competition and biofilm formation. CDI+ bacteria use cell-surface CdiA proteins to bind neighboring bact
Externí odkaz:
https://doaj.org/article/90ae1052ae834bcb839e3fe4b2cc38d4
Publikováno v:
Annu Rev Microbiol
Annual review of microbiology, vol 74, iss 1
Annual review of microbiology, vol 74, iss 1
All bacteria must compete for growth niches and other limited environmental resources. These existential battles are waged at several levels, but one common strategy entails the transfer of growth-inhibitory protein toxins between competing cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c03f823bc7b2660d908c14178a1993
https://doi.org/10.1146/annurev-micro-020518-115638
https://doi.org/10.1146/annurev-micro-020518-115638
Autor:
Tiffany Halvorsen, Nicholas L. Bartelli, David A. Low, Nicole A Chan, Josephine Y. Nguyen, Christopher S. Hayes, Zachary C. Ruhe, Fernando Garza-Sánchez
Publikováno v:
mBio, vol 12, iss 5
mBio
mBio, Vol 12, Iss 5 (2021)
mBio
mBio, Vol 12, Iss 5 (2021)
Contact-dependent growth inhibition (CDI) systems enable the direct transfer of protein toxins between competing Gram-negative bacteria. CDI+ strains produce cell surface CdiA effector proteins that bind specific receptors on neighboring bacteria to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b646284ab0de722142aaf0f85aba01d
https://escholarship.org/uc/item/3090s3bp
https://escholarship.org/uc/item/3090s3bp
Publikováno v:
mBio, Vol 4, Iss 4 (2013)
ABSTRACT Bacteria that express contact-dependent growth inhibition (CDI) systems outcompete siblings that lack immunity, suggesting that CDI mediates intercellular competition. To further explore the role of CDI in competition, we determined the targ
Externí odkaz:
https://doaj.org/article/1f7009aec0804475bfbffc76c460ec7e
Autor:
Sonya L Donato, Christina M. Beck, David A. Low, Christopher S. Hayes, Zachary C. Ruhe, Fernando Garza-Sánchez, Steven J Jensen, Ian Singleton, David Cunningham
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Bacteria deploy rearrangement hotspot (Rhs) proteins as toxic effectors against both prokaryotic and eukaryotic target cells. Rhs proteins are characterized by YD-peptide repeats, which fold into a large β-cage structure that encapsulates the C-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c50d9d5bb5a5e5d30e2b75ab976c3689
https://europepmc.org/articles/PMC7777165/
https://europepmc.org/articles/PMC7777165/
Autor:
Zachary C Ruhe, Christopher S Hayes
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15207 (2010)
The tmRNA quality control system recognizes stalled translation complexes and facilitates ribosome recycling in a process termed 'ribosome rescue'. During ribosome rescue, nascent chains are tagged with the tmRNA-encoded SsrA peptide, which targets t
Externí odkaz:
https://doaj.org/article/abff15af5730471a8d498949f0718a2d
Autor:
Grant J. Jensen, Poorna Subramanian, Zachary C. Ruhe, David A. Low, Christopher S. Hayes, Kiho Song, Josephine Y. Nguyen, Taylor A. Stevens
Publikováno v:
Cell, vol 175, iss 4
Contact-dependent growth inhibition (CDI) entails receptor-mediated delivery of CdiA-derived toxins into Gram-negative target bacteria. Using electron cryotomography, we show that each CdiA effector protein forms a filament extending ∼33nm from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ba776fc0f14174657fb8e55af3d6e7
https://escholarship.org/uc/item/4w2596c4
https://escholarship.org/uc/item/4w2596c4